cytokine release (Gilead Sciences)

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Gilead Sciences cytokine release
Cytokine Release, supplied by Gilead Sciences, used in various techniques. Bioz Stars score: 99/100, based on 15670 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/flexmap+3d+array+reader/VEKLURY/pmc07418728-162-10-25
Average 99 stars, based on 15670 article reviews

cytokine release - by Bioz Stars, 2026-11

99/100 stars

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Article Title: Regulatory Science for Veterinary Therapeutic Innovation: A Comparative Analysis of Drug Development Incentives Within the One Health Framework
Article Snippet: Notably, other jurisdictions—including Australia, the United Kingdom, Canada, and the Netherlands—established earlier access through compounding pharmacy frameworks and off-label use of remdesivir, creating an international regulatory asymmetry [9,12].

Article Title: An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir
Article Snippet: It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.

Standard Deviation:

Article Title: Test-retest reliability and interpretability of Long COVID Burden Index: A prospective observational study.
Article Snippet: 30 The Long COVID Burden Index (LCBI) is an 11-item patient-reported outcome measure 31 developed to assess the burden of long COVID symptoms on daily life.. Although its cross32 sectional validity and internal consistency have been demonstrated, its test–retest reliability, 33 measurement error, and minimal important change (MIC) have not yet been evaluated.. We 34 conducted a longitudinal postal survey among adults with a history of COVID-19 35 1 LCBI, Long COVID Burden Index; SEM, standard error of measurement; SDC, smallest detectable change; MIC, minimal important change; ICC, intraclass correlation coefficient; GRC, global rating of change; ROC, receiver operating characteristic; CI, confidence interval; NCGM, National Center for Global Health and Medicine; iCROWNL, Infectious Disease Clinical Research Network with National Repository; COVIREGI-JP, COVID-19 Registry Japan.

Analysis:

Article Title: Randomized controlled trial of pirfenidone XR for patients with COVID-19 and exploration of effects on long-COVID incidence.
Article Snippet: .. Percent returned to normal range was calculated out of the patients that present abnormal lab 592 values for each analyte at baseline. (Blue- treatment arm, Red- placebo) 593 594 595 Dexamethasone 105 (59%) 34 (59%) 71 (60%) 0.00 Tocilizumab or baricitinib 5 (3%) 3 (5%) 2 (2%) 0.20 Remdesivir 9 (5%) 3 (5%) 6 (5%) 0.01 597 * Normal lab values: LDH – (140 – 271 U/L), CRP (0 – 1mg/dL), Ferritin (23 – 336.2 ng/mL), DDimer (0 – 500 ng/mL FEU) 598 ** 116 ambulatory patients for which demographic data was available 599 600 601 602 607 608 Data statement 609 610 Protocol and statistical analysis plan will be made available upon request. ..

Food & Beverages:

Article Title: Modelling herpes simplex virus type 2 and Zika virus replication in mouse vaginal organoids and human vaginal spheroids.
Article Snippet: .. Remdesivir (RDV), an U.S. Food and Drug Administration (FDA)-approved antiviral drug to treat Ebola and SARS-CoV-2 infections (45), inhibits ZIKV replication in vitro (46), but its effect in vaginal cells has never been tested. ..

In Vitro:

Activity Assay:

Article Title: The pan-African natural products library compounds oleanolic acid, poinsettifolin B, and rhuschalcone III disrupt SARS-CoV-2 spike-host ACE2 interactions and SARS-CoV-2 replication
Article Snippet: .. This activity approached that of the positive control inhibitor remdesivir, which inhibited 85.8 ± 11.4% of virus replication at 10 μM, which in turn is consistent with its previously reported EC 50 of 7.3 μM by us in this assay [ ]. ..

Article Title: Highly effective viral RdRP translocation hindrance by the remdesivir nucleotide
Article Snippet: .. Remdesivir (RDV) is an adenosine analog with broad-spectrum antiviral activity against diverse RNA virus families and has been approved for COVID-19 treatment. ..

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Virus:

Functional Assay:

Article Title: Nanomedicines based on renewable materials for sustainable drug delivery and biomedical imaging applications
Article Snippet: , Acid- and basic-drug-loaded functional PJL micelles (mPEG-b-PJL-COOH) , To assess the effect of ionic functionalization on drug loading , Carboxyl-functionalized PJL micelles improved the encapsulation efficiency of weakly basic drugs such as carvedilol, sunitinib, and allopurinol through ionic interactions. , [ ] . .. , Remdesivir-loaded micelles of functional PJL (mPEG-b-PJL-COOH) , To enhance the solubility and bioavailability of remdesivir using PJL as substitute of β- cyclodextrin-based commercial formulation , Prepared micelles improved the solubility, bioavailability and stability of remdesivir. Antiviral efficacy was comparable to the marketed formulation (Jubi-R) with enhanced lung accumulation of the active remdesivir metabolite GS-441,524. , [ ] . .. Doxorubicin-conjugated redox-responsive PJL micelles , To develop a redox-responsive doxorubicin delivery system for cancer treatment , The micelles showed selective redox-triggered drug release in MDA-MB-231 cells, and cytotoxicity and microscopy studies supported intracellular release of doxorubicin. , [ ] .

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