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fgf21  (Multi Sciences (Lianke) Biotech Co Ltd)


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    Multi Sciences (Lianke) Biotech Co Ltd fgf21
    Fgf21, supplied by Multi Sciences (Lianke) Biotech Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/fgf21/Mouse+FGF-21+ELISA+Kit/pm41967182-155-19-22
    Average 90 stars, based on 2 article reviews
    fgf21 - by Bioz Stars, 2026-10
    90/100 stars

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    other:

    Article Title: Salivary pathobiont Klebsiella pneumoniae exacerbating periodontitis-related intestinal dyshomeostasis and accelerated metabolic syndrome.
    Article Snippet: Objective: The relationship between periodontitis and diabetes is well-established, yet the underlying mechanisms are incompletely understood.. This study aimed to investigate the role of Klebsiella pneumoniae (Kp94), isolated from the salivary microbiota of periodontitis patients, in exacerbating diabetes by disrupting intestinal immunity and metabolic homeostasis.. Design: Following the induction of periodontitis by ligation and oral gavage of Kp94, the systemic metabolic status of the mice was assessed through the Disease Activity Index (DAI), intraperitoneal glucose tolerance test (IPGTT), and measurements of serum total cholesterol (TC) and glycated hemoglobin (HbA1c).



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    Circulating biomarkers levels in chronic heart failure patients and controls

    Journal: ESC Heart Failure

    Article Title: Integrated miRNA-cytokine profiling reveals a molecular signature of cachexia in patients with chronic heart failure

    doi: 10.1093/eschf/xvag229

    Figure Lengend Snippet: Circulating biomarkers levels in chronic heart failure patients and controls

    Article Snippet: Serum concentrations of GDF-15 (#ELH-GDF15-1) and FGF-21 (#ELH-FGF21-1) were measured using ELISA (RayBiotech, Norcross, GA, USA) according to manufacturers’ instructions.

    Techniques:

    Circulating miRNAs and cytokines as molecular signatures of heart failure. Differences in serum levels of GDF-15 and FGF-21 in CHF patients and controls. Serum levels of GDF-15 by ELISA assay in patients with heart failure (HF) ( n = 25) and the control group ( n = 10). ( A ) Data showed significant upregulation of GDF-15 in CHF vs controls ( P < .001). ( B ) FGF-21 levels did not differ significantly between groups. Correlations between GDF-15 and selected miRNAs in CHF patients. ( C , D ) In CHF patients, GDF-15 levels were positively associated with miR-29b ( ρ = 0.42, P = .037) and miR-486 ( ρ = 0.42, P = .039). Data are expressed as fold change and are presented as mean ± SEM. Student's t -test or Mann–Whitney test was used for normally distributed data or non-normally distributed data, respectively. *** P ≤ .001.

    Journal: ESC Heart Failure

    Article Title: Integrated miRNA-cytokine profiling reveals a molecular signature of cachexia in patients with chronic heart failure

    doi: 10.1093/eschf/xvag229

    Figure Lengend Snippet: Circulating miRNAs and cytokines as molecular signatures of heart failure. Differences in serum levels of GDF-15 and FGF-21 in CHF patients and controls. Serum levels of GDF-15 by ELISA assay in patients with heart failure (HF) ( n = 25) and the control group ( n = 10). ( A ) Data showed significant upregulation of GDF-15 in CHF vs controls ( P < .001). ( B ) FGF-21 levels did not differ significantly between groups. Correlations between GDF-15 and selected miRNAs in CHF patients. ( C , D ) In CHF patients, GDF-15 levels were positively associated with miR-29b ( ρ = 0.42, P = .037) and miR-486 ( ρ = 0.42, P = .039). Data are expressed as fold change and are presented as mean ± SEM. Student's t -test or Mann–Whitney test was used for normally distributed data or non-normally distributed data, respectively. *** P ≤ .001.

    Article Snippet: Serum concentrations of GDF-15 (#ELH-GDF15-1) and FGF-21 (#ELH-FGF21-1) were measured using ELISA (RayBiotech, Norcross, GA, USA) according to manufacturers’ instructions.

    Techniques: Enzyme-linked Immunosorbent Assay, Control, MANN-WHITNEY

    Molecular profiles in CHF patients. Differences in serum levels of GDF-15 and FGF-21 among heart failure patients with and without cardiac cachexia. Circulating levels of GDF-15 and FGF-21 were analyzed in CHF patients with cardiac cachexia (CC) ( n = 10) and without cardiac cachexia (nCC) ( n = 15), and a control group ( n = 10). ( A ) Significant difference in GDF-15 levels was observed between patients with CC or nCC vs controls (all P < .001). ( B ) Levels of FGF-21 were significantly higher in CHF with CC compared with nCC ( P = .012) and vs controls ( P = .010) ( C ). Spearman’s correlation analysis revealed that in CHF patients with CC, GDF-15 negatively correlated with miR-21 ( ρ = −0.81, P = .007). ( D ) In the same group, FGF-21 negatively correlated with miR-486 ( ρ = −0.69, P = .035). Data are expressed as fold change and are presented as mean ± SEM. One-way ANOVA test or Kruskal–Wallis test was used for normally distributed data or non-normally distributed data, respectively. * P < .05, *** P ≤ .001.

    Journal: ESC Heart Failure

    Article Title: Integrated miRNA-cytokine profiling reveals a molecular signature of cachexia in patients with chronic heart failure

    doi: 10.1093/eschf/xvag229

    Figure Lengend Snippet: Molecular profiles in CHF patients. Differences in serum levels of GDF-15 and FGF-21 among heart failure patients with and without cardiac cachexia. Circulating levels of GDF-15 and FGF-21 were analyzed in CHF patients with cardiac cachexia (CC) ( n = 10) and without cardiac cachexia (nCC) ( n = 15), and a control group ( n = 10). ( A ) Significant difference in GDF-15 levels was observed between patients with CC or nCC vs controls (all P < .001). ( B ) Levels of FGF-21 were significantly higher in CHF with CC compared with nCC ( P = .012) and vs controls ( P = .010) ( C ). Spearman’s correlation analysis revealed that in CHF patients with CC, GDF-15 negatively correlated with miR-21 ( ρ = −0.81, P = .007). ( D ) In the same group, FGF-21 negatively correlated with miR-486 ( ρ = −0.69, P = .035). Data are expressed as fold change and are presented as mean ± SEM. One-way ANOVA test or Kruskal–Wallis test was used for normally distributed data or non-normally distributed data, respectively. * P < .05, *** P ≤ .001.

    Article Snippet: Serum concentrations of GDF-15 (#ELH-GDF15-1) and FGF-21 (#ELH-FGF21-1) were measured using ELISA (RayBiotech, Norcross, GA, USA) according to manufacturers’ instructions.

    Techniques: Control, Analysis

    Molecular profiles in cachectic patients with severe CHF. FGF-21 concentrations and their associations with NYHA functional class in patients with CHF. ( A ) Data show higher FGF-21 levels in NYHA class III-IV ( n = 13) compared with class I-II ( n = 9) ( P = .050) and the control group ( n = 10) ( P = .050). ( B ) In NYHA class III-IV, FGF-21 positively correlated with miR-15b ( r = 0.68, P = .014). Data are expressed as fold change and are presented as mean ± SEM. One-way ANOVA test or Kruskal–Wallis test was used for normally distributed data or non-normally distributed data, respectively. * P < .05.

    Journal: ESC Heart Failure

    Article Title: Integrated miRNA-cytokine profiling reveals a molecular signature of cachexia in patients with chronic heart failure

    doi: 10.1093/eschf/xvag229

    Figure Lengend Snippet: Molecular profiles in cachectic patients with severe CHF. FGF-21 concentrations and their associations with NYHA functional class in patients with CHF. ( A ) Data show higher FGF-21 levels in NYHA class III-IV ( n = 13) compared with class I-II ( n = 9) ( P = .050) and the control group ( n = 10) ( P = .050). ( B ) In NYHA class III-IV, FGF-21 positively correlated with miR-15b ( r = 0.68, P = .014). Data are expressed as fold change and are presented as mean ± SEM. One-way ANOVA test or Kruskal–Wallis test was used for normally distributed data or non-normally distributed data, respectively. * P < .05.

    Article Snippet: Serum concentrations of GDF-15 (#ELH-GDF15-1) and FGF-21 (#ELH-FGF21-1) were measured using ELISA (RayBiotech, Norcross, GA, USA) according to manufacturers’ instructions.

    Techniques: Functional Assay, Control

    Schematic representation of the circulating molecular profile associated with chronic heart failure and cardiac cachexia, characterized by dysregulation of muscle- and remodelling-related miRNAs and increased stress-responsive cytokines. CHF patients showed reduced miR-15b, miR-29b, miR-133a, and miR-486 and increased GDF-15, while cardiac cachexia was further associated with lower miR-29b and higher FGF-21 levels.

    Journal: ESC Heart Failure

    Article Title: Integrated miRNA-cytokine profiling reveals a molecular signature of cachexia in patients with chronic heart failure

    doi: 10.1093/eschf/xvag229

    Figure Lengend Snippet: Schematic representation of the circulating molecular profile associated with chronic heart failure and cardiac cachexia, characterized by dysregulation of muscle- and remodelling-related miRNAs and increased stress-responsive cytokines. CHF patients showed reduced miR-15b, miR-29b, miR-133a, and miR-486 and increased GDF-15, while cardiac cachexia was further associated with lower miR-29b and higher FGF-21 levels.

    Article Snippet: Serum concentrations of GDF-15 (#ELH-GDF15-1) and FGF-21 (#ELH-FGF21-1) were measured using ELISA (RayBiotech, Norcross, GA, USA) according to manufacturers’ instructions.

    Techniques: