exome sequencing wes data (Broad Clinical Labs)
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Broad Clinical Labs
exome sequencing wes data
Exome Sequencing Wes Data, supplied by Broad Clinical Labs, used in various techniques. Bioz Stars score: 95/100, based on 311 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/exome+sequence+data/Whole+Exome+Sequencing/pmc12802574-231-9-16
Average 95 stars, based on 311 article reviews
Exome Sequencing Wes Data, supplied by Broad Clinical Labs, used in various techniques. Bioz Stars score: 95/100, based on 311 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/exome+sequence+data/Whole+Exome+Sequencing/pmc12802574-231-9-16
Average 95 stars, based on 311 article reviews
exome sequencing wes data - by Bioz Stars,
2026-11
95/100 stars
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1) Product Images from "Detection of heterogeneous resistance mechanisms to tyrosine kinase inhibitors from cell-free DNA"
Article Title: Detection of heterogeneous resistance mechanisms to tyrosine kinase inhibitors from cell-free DNA
Journal: Cell Genomics
doi: 10.1016/j.xgen.2025.100987
Figure Legend Snippet: Study design for patient cohorts and genomic analyses (A) Initial study criteria with study design based on sample availability and treatment timing. After whole-exome sequencing, PhylogicNDT and SignatureAnalyzer were used to identify clones and compare mutational signatures, respectively. Functional mutations were characterized based on existing evidence previously published or annotated in genomic databases, such as COSMIC, ClinVar, and OncoKB. (B) Signaling pathway landscape for paired-cohort participants ( n = 26) organized by time on tyrosine kinase treatment (days by sampled TKI) and acquired ( n = 8) or intrinsic ( n = 18) resistance. Known mechanisms in ERBB2 and PIK3CA are highlighted. Signaling pathways are depicted in decreasing frequency per number of mutations for the entire cohort of paired participants. Arrows indicate the subclonal trajectory as either growing, stable, or shrinking. The TP53 and ESR1+ regulator pathways were significantly mutated ( q < 0.05; MutSig, Fisher’s method). Stacked bar charts indicate relative contributions of mutational signatures identified by SignatureAnalyzer to the mutational spectrum of each participant. (C) Pathway-level comparison of mutation frequency between four cohorts: intrinsic ( n = 18), acquired ( n = 8), pre-TKI ( n = 55), and post-TKI ( n = 30). Pathways were included if they possessed at least one mutation. There were no significant differences in pathway-level mutation frequency between cohorts (Fisher’s exact test).
Techniques Used: Sequencing, Clone Assay, Functional Assay, Protein-Protein interactions, Comparison, Mutagenesis
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