Review



epityper  (INFINIUM Inc)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    INFINIUM Inc epityper
    Neither SOD1 nor C9orf72 CpG islands are differentially methylated between mutation-positive ALS-discordant twins/triplets. The relative location of targeted CpG islands (CGI) and exon 1 are indicated for SOD1 ( A , top) and C9orf72 ( B , top). ( A ) Methylation of the CpG island spanning the promoter region and exon 1 of SOD1 does not show differential methylation between an ALS-affected triplet and unaffected co-triplets, concordant for SOD1 p.I114T. Methylation status was determined using both <t>EpiTYPER</t> (bottom) and 450K (middle) assays. ( B ) Transcript variants (T1, T2, and T3) and the position of the repeat expansion (black diamond) relative to exon 1 are shown for C9orf72 (top). Methylation of the C9orf72 promoter region/expansion flanking CpG islands are not differentially methylated between ALS-discordant co-twins that carry the C9orf72 hexanucleotide repeat expansion in either EpiTYPER (bottom) or 450K data sets (middle).
    Epityper, supplied by INFINIUM Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/epityper+validation+help+data/epityper/pmc06547746-63-8-16
    Average 90 stars, based on 1 article reviews
    epityper - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression"

    Article Title: Monozygotic twins and triplets discordant for amyotrophic lateral sclerosis display differential methylation and gene expression

    Journal: Scientific Reports

    doi: 10.1038/s41598-019-44765-4

    Neither SOD1 nor C9orf72 CpG islands are differentially methylated between mutation-positive ALS-discordant twins/triplets. The relative location of targeted CpG islands (CGI) and exon 1 are indicated for SOD1 ( A , top) and C9orf72 ( B , top). ( A ) Methylation of the CpG island spanning the promoter region and exon 1 of SOD1 does not show differential methylation between an ALS-affected triplet and unaffected co-triplets, concordant for SOD1 p.I114T. Methylation status was determined using both EpiTYPER (bottom) and 450K (middle) assays. ( B ) Transcript variants (T1, T2, and T3) and the position of the repeat expansion (black diamond) relative to exon 1 are shown for C9orf72 (top). Methylation of the C9orf72 promoter region/expansion flanking CpG islands are not differentially methylated between ALS-discordant co-twins that carry the C9orf72 hexanucleotide repeat expansion in either EpiTYPER (bottom) or 450K data sets (middle).
    Figure Legend Snippet: Neither SOD1 nor C9orf72 CpG islands are differentially methylated between mutation-positive ALS-discordant twins/triplets. The relative location of targeted CpG islands (CGI) and exon 1 are indicated for SOD1 ( A , top) and C9orf72 ( B , top). ( A ) Methylation of the CpG island spanning the promoter region and exon 1 of SOD1 does not show differential methylation between an ALS-affected triplet and unaffected co-triplets, concordant for SOD1 p.I114T. Methylation status was determined using both EpiTYPER (bottom) and 450K (middle) assays. ( B ) Transcript variants (T1, T2, and T3) and the position of the repeat expansion (black diamond) relative to exon 1 are shown for C9orf72 (top). Methylation of the C9orf72 promoter region/expansion flanking CpG islands are not differentially methylated between ALS-discordant co-twins that carry the C9orf72 hexanucleotide repeat expansion in either EpiTYPER (bottom) or 450K data sets (middle).

    Techniques Used: Methylation, Mutagenesis

    Twin cohort details.
    Figure Legend Snippet: Twin cohort details.

    Techniques Used: Mutagenesis, Sampling, Control

    Related Articles

    DNA Methylation Assay:

    Article Title: A Comparison of Forensic Age Prediction Models Using Data From Four DNA Methylation Technologies
    Article Snippet: Nevertheless, it is important to note the underestimation of predicted age using pyrosequencing ( ) to test common controls older than 60 years. .. In addition to this, previous replication experiments had indicated reproducibility for DNA methylation levels detected using EpiTYPER ® , MPS , and pyrosequencing ( ) compared with data from Infinium BeadChip arrays. .. This is an important factor to consider, since discovery studies are predominantly based on Infinium arrays, and identified age-associated CpG sites are subsequently validated using targeted DNA methylation technologies.



    Similar Products

    epityper validation help data  (Sequenom)
    90
    Sequenom epityper validation help data
    Epityper Validation Help Data, supplied by Sequenom, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/epityper+validation+help+data/epityper+validation+help+data/pmc03008568-250-5-24
    Average 90 stars, based on 1 article reviews
    epityper validation help data - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results