endopredict tests (Sividon Diagnostics GmbH)

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Sividon Diagnostics GmbH endopredict tests

<t>EndoPredict</t> test results achieved after different storage times and temperatures before fixation. The solid line represents the reference score which was derived from the mean EP score of the tissue sections that have been stored for 10 min at 20 °C before fixation. Dotted lines represent the reference score ±3× its standard deviation as determined by precision study . Measurements were performed in duplicate ( n = 2). Mean values are presented, with standard errors of the means indicated by bars

Endopredict Tests, supplied by Sividon Diagnostics GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/endopredict/endopredict+test/pmc04180906-115-0-2
Average 90 stars, based on 1 article reviews

endopredict tests - by Bioz Stars, 2026-09

90/100 stars

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1) Product Images from "Preanalytical variables and performance of diagnostic RNA-based gene expression analysis in breast cancer"

Article Title: Preanalytical variables and performance of diagnostic RNA-based gene expression analysis in breast cancer

Journal: Virchows Archiv

doi: 10.1007/s00428-014-1652-0

EndoPredict test results achieved after different storage times and temperatures before fixation. The solid line represents the reference score which was derived from the mean EP score of the tissue sections that have been stored for 10 min at 20 °C before fixation. Dotted lines represent the reference score ±3× its standard deviation as determined by precision study . Measurements were performed in duplicate ( n = 2). Mean values are presented, with standard errors of the means indicated by bars

Figure Legend Snippet: EndoPredict test results achieved after different storage times and temperatures before fixation. The solid line represents the reference score which was derived from the mean EP score of the tissue sections that have been stored for 10 min at 20 °C before fixation. Dotted lines represent the reference score ±3× its standard deviation as determined by precision study . Measurements were performed in duplicate ( n = 2). Mean values are presented, with standard errors of the means indicated by bars

Techniques Used: Derivative Assay, Standard Deviation

EndoPredict test results achieved after different fixation times. The solid line represents the reference score which was derived from the mean EP score of the tissue sections that have been fixed for 20 h in neutral buffered formalin. Dotted lines represent the reference score ±3× its standard deviation as determined by precision study . Measurements were performed in duplicate ( n = 2). Mean values are presented, with standard errors of the means indicated by bars

Figure Legend Snippet: EndoPredict test results achieved after different fixation times. The solid line represents the reference score which was derived from the mean EP score of the tissue sections that have been fixed for 20 h in neutral buffered formalin. Dotted lines represent the reference score ±3× its standard deviation as determined by precision study . Measurements were performed in duplicate ( n = 2). Mean values are presented, with standard errors of the means indicated by bars

Techniques Used: Derivative Assay, Standard Deviation

Correlation of the relative expression values of the EndoPredict genes of interest between whole sections and manually microdissected sections

Figure Legend Snippet: Correlation of the relative expression values of the EndoPredict genes of interest between whole sections and manually microdissected sections

Techniques Used: Expressing

Correlation between the EP ( a ) and EPclin ( b ) scores of paired whole and tumor-enriched, manually microdissected tissue sections from ER+/HER2− breast cancer patients ( n = 39). Pearson correlation coefficient of EP scores was 0.97 with a concordance of EndoPredict risk classification of 87 %. Pearson correlation coefficient of EPclin scores was 0.98 with a concordance of EndoPredict risk classification of 95 %. Black filled circles represent tissue samples with TCC ≥30 %, open circles tissue sections with TCC <30 %

Figure Legend Snippet: Correlation between the EP ( a ) and EPclin ( b ) scores of paired whole and tumor-enriched, manually microdissected tissue sections from ER+/HER2− breast cancer patients ( n = 39). Pearson correlation coefficient of EP scores was 0.97 with a concordance of EndoPredict risk classification of 87 %. Pearson correlation coefficient of EPclin scores was 0.98 with a concordance of EndoPredict risk classification of 95 %. Black filled circles represent tissue samples with TCC ≥30 %, open circles tissue sections with TCC <30 %

Techniques Used:

Mean difference of relative expression values (delta Cq value [nonstored]-delta Cq value [stored]) of the EndoPredict genes of interest between nonstored and stored FFPE tissue sections

Figure Legend Snippet: Mean difference of relative expression values (delta Cq value [nonstored]-delta Cq value [stored]) of the EndoPredict genes of interest between nonstored and stored FFPE tissue sections

Techniques Used: Expressing

Correlation of EP scores between stored and nonstored FFPE tissue sections. EP scores have been determined at the beginning of the study, after 12 months at +4 °C ( a ) or after 12 months at +20 °C ( b ), respectively. Pearson correlation coefficients were 0.99 and >0.99 with a concordance of EndoPredict risk classification of 100 %

Figure Legend Snippet: Correlation of EP scores between stored and nonstored FFPE tissue sections. EP scores have been determined at the beginning of the study, after 12 months at +4 °C ( a ) or after 12 months at +20 °C ( b ), respectively. Pearson correlation coefficients were 0.99 and >0.99 with a concordance of EndoPredict risk classification of 100 %

Techniques Used:

Expressing:

Article Title: Predicting the response to neoadjuvant therapy for early-stage breast cancer: tumor-, blood-, and imaging-related biomarkers
Article Snippet: .. The Prosigna test (previously known as PAM50; NanoString Technologies, Seattle, WA, USA) , measures the expression of 50 genes at the mRNA level, the EndoPredict test detects the expression levels of 11 genes (Sividon Diagnostics GmbH, Cologne, Germany), and the BCI (bioTheranostics, San Diego, CA, USA) test measures the expression of 11 genes. ..

other:

Article Title: Risk Assessment after Neoadjuvant Chemotherapy in Luminal Breast Cancer Using a Clinicomolecular Predictor
Article Snippet: Karsten Weber holded shares in Sividon Diagnostics, holds patent property for the EndoPredict test from Sividon Diagnostics.

Article Title: Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial
Article Snippet: Karsten Weber holds shares from Sividon Diagnostics and patent property for the EndoPredict test from Sividon Diagnostics.

Gene Expression:

Article Title: Gene Expression Analyses in Early Breast Carcinoma — Quo Vadis?
Article Snippet: .. EndoPredict® The EndoPredict® (EP) test (Sividon Diagnostics GmbH, Cologne, Germany; distributed by Myriad Genetics Inc., Salt Lake City, 210 Almstedt K et al. Gene Expression Analyses... Senologie 2017; 14: 209–213 Utah, USA) allows qRT-PCR to be carried out on paraffin-embedded material on a decentralized basis. ..

Quantitative RT-PCR:

Reverse Transcription Polymerase Chain Reaction:

Article Title: Molecular Genomic Testing for Breast Cancer: Utility for Surgeons.
Article Snippet: .. The EndoPredict Test (Sividon Diagnostics, Köln, Germany) combines EndoPredict—an eight-gene, mRNAbased assay that uses RT-PCR on FFPE tumor samples— with patient tumor size and nodal status to assign patients with early-stage, ER?, HER2- breast cancer a score that reflects likelihood of distant recurrence within 10 years of diagnosis. ..

Article Title: Molecular Genomic Testing for Breast Cancer: Utility for Surgeons
Article Snippet: .. EndoPredict The EndoPredict Test ® (Sividon Diagnostics, Köln, Germany) combines EndoPredict–an 8-gene, mRNA-based assay that uses RT-PCR on FFPE tumor samples – with patient tumor size and nodal status to assign patients with early-stage, ER+, HER2− breast cancer a score that reflects likelihood of distant recurrence within 10 years of diagnosis. ..

Article Title: Molecular Genomic Testing for Breast Cancer: Utility for Surgeons
Article Snippet: .. The EndoPredict Test ® (Sividon Diagnostics, Köln, Germany) combines EndoPredict–an 8-gene, mRNA-based assay that uses RT-PCR on FFPE tumor samples – with patient tumor size and nodal status to assign patients with early-stage, ER+, HER2− breast cancer a score that reflects likelihood of distant recurrence within 10 years of diagnosis. ..

Formalin-fixed Paraffin-Embedded:

Article Title: Innovation in cancer pharmacotherapy through integrative consideration of germline and tumor genomes .
Article Snippet: .. The EndoPredict Test (originally Sividon Diagnostics, Köln, Germany now Myriad International GmbH, Cologne, Germany) started as an 8-gene test and was expanded to a 12-gene quantitative PCR (qPCR) test on formalin-fixed paraffin-embedded (FFPE) tumor samples (Filipits et al., 2011). ..

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endopredict tests (Sividon Diagnostics GmbH)

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Images

1) Product Images from "Preanalytical variables and performance of diagnostic RNA-based gene expression analysis in breast cancer"

Related Articles

Expressing:

other:

Gene Expression:

Quantitative RT-PCR:

Reverse Transcription Polymerase Chain Reaction:

Formalin-fixed Paraffin-Embedded:

Biomarker Discovery:

Real-time Polymerase Chain Reaction:

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