dhs  (Gerstel GmbH)

Journal: Journal of Taibah University Medical Sciences

Article Title: Computational discovery of fenugreek–paitan–turmeric (FPT) bioactive compounds targeting SGLT2 and DPP-4 for glucose homeostasis regulation

doi: 10.1016/j.jtumed.2026.05.008

Figure Lengend Snippet: Molecular dynamics–based analyses of DPP4 and SGLT2: (a) root mean square fluctuation (RMSF), (b) dynamic cross-correlation matrix (DCCM), and (c) principal component analysis (PCA).

Article Snippet: Molecular dynamics–based analyses of DPP4 and SGLT2: (a) root mean square fluctuation (RMSF), (b) dynamic cross-correlation matrix (DCCM), and (c) principal component analysis (PCA).

Techniques:

Journal: Neurotherapeutics

Article Title: Pulsed focused ultrasound for seizure suppression: Mechanisms, models, and clinical translation

doi: 10.1016/j.neurot.2026.e00920

Figure Lengend Snippet: Integrated mechanistic framework of pFUS-mediated seizure suppression. pFUS modulates neural activity through dual cellular pathways: the preferential activation of GABAergic interneurons and astrocytic mechano-transduction, leading to disrupted hypersynchrony and restored excitation–inhibition balance. These cellular effects propagate to network-level modulation, characterized by desynchronization and increased signal complexity. Ultimately, these processes drive system-level outcomes, including acute seizure reduction and long-term benefits mediated by neuroprotection.

Article Snippet: 3 , KA chronic epilepsy C57BL/6 mice (N = 14)/KA injection at CA3 region , MI: 0.37, I SPTA : 1.13 W/cm 2 (with skull attenuation), DC: 50 %, SD: 30 s, one session , pFUS-seizure suppression correlated with restoration of neural signal complexity: Approximate entropy increased (delta and theta band); largest lyapunov exponent increased. pFUS restored normal nonlinear dynamics , [ ] .

Techniques: Activity Assay, Activation Assay, Transduction, Inhibition