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1, 2-dihexanoyl-sn-glycero-3-phosphocholine (dhpc  (Avanti Inc)

 
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    Structured Review

    Avanti Inc 1, 2-dihexanoyl-sn-glycero-3-phosphocholine (dhpc
    Phospholipid head group selectivity of hGIIE. ( a–c ) Enzymatic activity of hGIIE determined by isothermal titration calorimetry method: ( a ) 1, <t>2-dihexanoyl-sn-glycero-3-</t> phosphor-ethanolamine (DHPE); ( b ) 1, <t>2-dihexanoyl-sn-glycero-3-phosphor-rac-1-glycerol</t> (DHPG); ( c ) 1, 2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC). Heat flows are converted to specific enzyme activities. The raw titration curves are shown in the inserts. Data is fitted to the standard Michaelis-Menten equation, trend line is shown in red. ( d–f ) Docking model of hGIIE with the phospholipid: ( d ) hGIIE-DHPE; ( e ) hGIIE-DHPG; ( f ) hGIIE-DHPC. Hydrogen bond interaction is indicated by black dash lines, and residues involved are shown as stick.
    1, 2 Dihexanoyl Sn Glycero 3 Phosphocholine (Dhpc, supplied by Avanti Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dphpc/pmc05589937-243-1-12?v=Avanti+Inc
    Average 90 stars, based on 1 article reviews
    1, 2-dihexanoyl-sn-glycero-3-phosphocholine (dhpc - by Bioz Stars, 2026-08
    90/100 stars

    Images

    1) Product Images from "Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A 2 group IIE"

    Article Title: Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A 2 group IIE

    Journal: Scientific Reports

    doi: 10.1038/s41598-017-11219-8

    Phospholipid head group selectivity of hGIIE. ( a–c ) Enzymatic activity of hGIIE determined by isothermal titration calorimetry method: ( a ) 1, 2-dihexanoyl-sn-glycero-3- phosphor-ethanolamine (DHPE); ( b ) 1, 2-dihexanoyl-sn-glycero-3-phosphor-rac-1-glycerol (DHPG); ( c ) 1, 2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC). Heat flows are converted to specific enzyme activities. The raw titration curves are shown in the inserts. Data is fitted to the standard Michaelis-Menten equation, trend line is shown in red. ( d–f ) Docking model of hGIIE with the phospholipid: ( d ) hGIIE-DHPE; ( e ) hGIIE-DHPG; ( f ) hGIIE-DHPC. Hydrogen bond interaction is indicated by black dash lines, and residues involved are shown as stick.
    Figure Legend Snippet: Phospholipid head group selectivity of hGIIE. ( a–c ) Enzymatic activity of hGIIE determined by isothermal titration calorimetry method: ( a ) 1, 2-dihexanoyl-sn-glycero-3- phosphor-ethanolamine (DHPE); ( b ) 1, 2-dihexanoyl-sn-glycero-3-phosphor-rac-1-glycerol (DHPG); ( c ) 1, 2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC). Heat flows are converted to specific enzyme activities. The raw titration curves are shown in the inserts. Data is fitted to the standard Michaelis-Menten equation, trend line is shown in red. ( d–f ) Docking model of hGIIE with the phospholipid: ( d ) hGIIE-DHPE; ( e ) hGIIE-DHPG; ( f ) hGIIE-DHPC. Hydrogen bond interaction is indicated by black dash lines, and residues involved are shown as stick.

    Techniques Used: Activity Assay, Isothermal Titration Calorimetry, Titration



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    A) Structure <t>of</t> <t>DLPC</t> and <t>DPhPC.</t> B) The fluorescence emission spectra of Laurdan for each lipid composition. C) The GP value of Laurdan for each lipid composition. D) The average fraction of oxidized C11-BODIPY over time for each diameter bin. E) The initial rate of oxidation as a function of vesicle diameter. The change in the fraction of oxidized C11-BODIPY after F) 10 minutes and G) 30 minutes of oxidation, relative to its initial value for each diameter bin. H) Representative fluorescence micrographs of MBLs before and after photobleaching (scale bar: 5 μm). I) Fluorescence recovery in MBLs over time. The red lines represent the lines of best fit from equation S7. J) Diffusion coefficients for each lipid composition. All vesicles used in panel B and C were composed of DLPC or DPhPC (99.8 mol%) and Laurdan (0.2 mol%). All vesicles used in panel D-G were composed of DPhPC (98.5 mol%), C11-BODIPY (0.5 mol%), DPPE-ATTO 647N (0.5 mol%), and DSPE-PEG(2000)-Biotin (0.5 mol%), and oxidation was induced using 7.5 μM H 2 O 2 and 0.15 μM FeSO 4 . The number of DPhPC SUVs in each diameter bin varied from 140–4959. Data points or bars in D-G represent the average value of the bin and the error bars correspond to the standard error of the mean for each bin. Each value displayed for a bin represents the midpoint of the bin. All bins were symmetric, with endpoints aligned to the start of the next bin, ensuring no overlap. MBLs used in panel H-J were composed of DLPC or DPhPC (99.875 mol%) and DPPE-ATTO 647N (0.125 mol%). Data points in I represent the average normalized fluorescence intensity. Bars in J represent the mean and the error bars correspond to the standard deviation ( N =5, unpaired, two-sample t-test, ****P<0.0001).
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    A) Structure <t>of</t> <t>DLPC</t> and <t>DPhPC.</t> B) The fluorescence emission spectra of Laurdan for each lipid composition. C) The GP value of Laurdan for each lipid composition. D) The average fraction of oxidized C11-BODIPY over time for each diameter bin. E) The initial rate of oxidation as a function of vesicle diameter. The change in the fraction of oxidized C11-BODIPY after F) 10 minutes and G) 30 minutes of oxidation, relative to its initial value for each diameter bin. H) Representative fluorescence micrographs of MBLs before and after photobleaching (scale bar: 5 μm). I) Fluorescence recovery in MBLs over time. The red lines represent the lines of best fit from equation S7. J) Diffusion coefficients for each lipid composition. All vesicles used in panel B and C were composed of DLPC or DPhPC (99.8 mol%) and Laurdan (0.2 mol%). All vesicles used in panel D-G were composed of DPhPC (98.5 mol%), C11-BODIPY (0.5 mol%), DPPE-ATTO 647N (0.5 mol%), and DSPE-PEG(2000)-Biotin (0.5 mol%), and oxidation was induced using 7.5 μM H 2 O 2 and 0.15 μM FeSO 4 . The number of DPhPC SUVs in each diameter bin varied from 140–4959. Data points or bars in D-G represent the average value of the bin and the error bars correspond to the standard error of the mean for each bin. Each value displayed for a bin represents the midpoint of the bin. All bins were symmetric, with endpoints aligned to the start of the next bin, ensuring no overlap. MBLs used in panel H-J were composed of DLPC or DPhPC (99.875 mol%) and DPPE-ATTO 647N (0.125 mol%). Data points in I represent the average normalized fluorescence intensity. Bars in J represent the mean and the error bars correspond to the standard deviation ( N =5, unpaired, two-sample t-test, ****P<0.0001).
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    Image Search Results


    A) Structure of DLPC and DPhPC. B) The fluorescence emission spectra of Laurdan for each lipid composition. C) The GP value of Laurdan for each lipid composition. D) The average fraction of oxidized C11-BODIPY over time for each diameter bin. E) The initial rate of oxidation as a function of vesicle diameter. The change in the fraction of oxidized C11-BODIPY after F) 10 minutes and G) 30 minutes of oxidation, relative to its initial value for each diameter bin. H) Representative fluorescence micrographs of MBLs before and after photobleaching (scale bar: 5 μm). I) Fluorescence recovery in MBLs over time. The red lines represent the lines of best fit from equation S7. J) Diffusion coefficients for each lipid composition. All vesicles used in panel B and C were composed of DLPC or DPhPC (99.8 mol%) and Laurdan (0.2 mol%). All vesicles used in panel D-G were composed of DPhPC (98.5 mol%), C11-BODIPY (0.5 mol%), DPPE-ATTO 647N (0.5 mol%), and DSPE-PEG(2000)-Biotin (0.5 mol%), and oxidation was induced using 7.5 μM H 2 O 2 and 0.15 μM FeSO 4 . The number of DPhPC SUVs in each diameter bin varied from 140–4959. Data points or bars in D-G represent the average value of the bin and the error bars correspond to the standard error of the mean for each bin. Each value displayed for a bin represents the midpoint of the bin. All bins were symmetric, with endpoints aligned to the start of the next bin, ensuring no overlap. MBLs used in panel H-J were composed of DLPC or DPhPC (99.875 mol%) and DPPE-ATTO 647N (0.125 mol%). Data points in I represent the average normalized fluorescence intensity. Bars in J represent the mean and the error bars correspond to the standard deviation ( N =5, unpaired, two-sample t-test, ****P<0.0001).

    Journal: bioRxiv

    Article Title: Membrane curvature enhances lipid peroxidation in a composition-dependent manner

    doi: 10.64898/2025.12.03.692219

    Figure Lengend Snippet: A) Structure of DLPC and DPhPC. B) The fluorescence emission spectra of Laurdan for each lipid composition. C) The GP value of Laurdan for each lipid composition. D) The average fraction of oxidized C11-BODIPY over time for each diameter bin. E) The initial rate of oxidation as a function of vesicle diameter. The change in the fraction of oxidized C11-BODIPY after F) 10 minutes and G) 30 minutes of oxidation, relative to its initial value for each diameter bin. H) Representative fluorescence micrographs of MBLs before and after photobleaching (scale bar: 5 μm). I) Fluorescence recovery in MBLs over time. The red lines represent the lines of best fit from equation S7. J) Diffusion coefficients for each lipid composition. All vesicles used in panel B and C were composed of DLPC or DPhPC (99.8 mol%) and Laurdan (0.2 mol%). All vesicles used in panel D-G were composed of DPhPC (98.5 mol%), C11-BODIPY (0.5 mol%), DPPE-ATTO 647N (0.5 mol%), and DSPE-PEG(2000)-Biotin (0.5 mol%), and oxidation was induced using 7.5 μM H 2 O 2 and 0.15 μM FeSO 4 . The number of DPhPC SUVs in each diameter bin varied from 140–4959. Data points or bars in D-G represent the average value of the bin and the error bars correspond to the standard error of the mean for each bin. Each value displayed for a bin represents the midpoint of the bin. All bins were symmetric, with endpoints aligned to the start of the next bin, ensuring no overlap. MBLs used in panel H-J were composed of DLPC or DPhPC (99.875 mol%) and DPPE-ATTO 647N (0.125 mol%). Data points in I represent the average normalized fluorescence intensity. Bars in J represent the mean and the error bars correspond to the standard deviation ( N =5, unpaired, two-sample t-test, ****P<0.0001).

    Article Snippet: DLPC (1,2-dilauroyl-sn-glycero-3-phosphocholine, 850335), DPhPC (1,2-diphytanoyl-sn-glycero-3-phosphocholine, 850356), POPC (1-palmitoyl-2-oleoyl-glycero-3-phosphocholine, 850457), DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine, 850375), cholesterol (700100), DLiPC (1,2-dilinoleoyl-sn-glycero-3-phosphocholine, 850385), DSPE-PEG(2000)-Biotin (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (ammonium salt), 880129) were purchased from Avanti Polar Lipids.

    Techniques: Fluorescence, Diffusion-based Assay, Standard Deviation

    A) Structure of DLiPC. B) Fluorescence recovery in SBLs over time. The lines represent the best fits with equation S7. C) Lateral diffusion coefficients for each membrane composition. D) The initial rate of oxidation as a function of vesicle diameter. The change in the fraction of oxidized C11-BODIPY after E) 5 minutes and F) 10 minutes of oxidation, relative to its initial value for each diameter bin. SBLs used in panel B and C were primarily composed of DOPC, 1:1 DLiPC:DPhPC (50% DLiPC), or 3:1 DLiPC:DPhPC (75% DLiPC), and contained 0.125 mol% DPPE-ATTO 647N. Data points in B represent the average normalized fluorescence intensity. Bars in C represent the mean and the error bars correspond to the standard deviation ( N =4 for DOPC, and N =5 for 50% DLiPC and 75% DLiPC, unpaired, two-sample t-test, ns: non-significance, *P<0.05). All vesicles used in panel D-F were primarily composed of DOPC, 1:1 DLiPC:DPhPC (50% DLiPC), or 3:1 DLiPC:DPhPC (75% DLiPC), and contained C11-BODIPY (0.5 mol%), DPPE-ATTO 647N (0.5 mol%), and DSPE-PEG(2000)-Biotin (0.5 mol%). Oxidation was induced using 7.5 μM H 2 O 2 and 0.15 μM FeSO 4 . The number of SUVs in each diameter bin varied from 320–4502 (50% DLiPC), and 263–3100 (75% DLiPC). Bars in D represent the average initial rate of oxidation calculated from linear regression of three time points (0, 5, and 10 minutes, solid fill) or slope of the first two time points (0 and 5 minutes, patterned fill) and the error bars correspond to the standard error calculated from linear regression (solid fill) or propagated error from the standard error (patterned fill). Bars in E and F represent the average value of the bin, and the error bars correspond to the standard error of difference. Each value displayed for a bin represents the midpoint of the bin. All bins were symmetric, with endpoints aligned to the start of the next bin, ensuring no overlap.

    Journal: bioRxiv

    Article Title: Membrane curvature enhances lipid peroxidation in a composition-dependent manner

    doi: 10.64898/2025.12.03.692219

    Figure Lengend Snippet: A) Structure of DLiPC. B) Fluorescence recovery in SBLs over time. The lines represent the best fits with equation S7. C) Lateral diffusion coefficients for each membrane composition. D) The initial rate of oxidation as a function of vesicle diameter. The change in the fraction of oxidized C11-BODIPY after E) 5 minutes and F) 10 minutes of oxidation, relative to its initial value for each diameter bin. SBLs used in panel B and C were primarily composed of DOPC, 1:1 DLiPC:DPhPC (50% DLiPC), or 3:1 DLiPC:DPhPC (75% DLiPC), and contained 0.125 mol% DPPE-ATTO 647N. Data points in B represent the average normalized fluorescence intensity. Bars in C represent the mean and the error bars correspond to the standard deviation ( N =4 for DOPC, and N =5 for 50% DLiPC and 75% DLiPC, unpaired, two-sample t-test, ns: non-significance, *P<0.05). All vesicles used in panel D-F were primarily composed of DOPC, 1:1 DLiPC:DPhPC (50% DLiPC), or 3:1 DLiPC:DPhPC (75% DLiPC), and contained C11-BODIPY (0.5 mol%), DPPE-ATTO 647N (0.5 mol%), and DSPE-PEG(2000)-Biotin (0.5 mol%). Oxidation was induced using 7.5 μM H 2 O 2 and 0.15 μM FeSO 4 . The number of SUVs in each diameter bin varied from 320–4502 (50% DLiPC), and 263–3100 (75% DLiPC). Bars in D represent the average initial rate of oxidation calculated from linear regression of three time points (0, 5, and 10 minutes, solid fill) or slope of the first two time points (0 and 5 minutes, patterned fill) and the error bars correspond to the standard error calculated from linear regression (solid fill) or propagated error from the standard error (patterned fill). Bars in E and F represent the average value of the bin, and the error bars correspond to the standard error of difference. Each value displayed for a bin represents the midpoint of the bin. All bins were symmetric, with endpoints aligned to the start of the next bin, ensuring no overlap.

    Article Snippet: DLPC (1,2-dilauroyl-sn-glycero-3-phosphocholine, 850335), DPhPC (1,2-diphytanoyl-sn-glycero-3-phosphocholine, 850356), POPC (1-palmitoyl-2-oleoyl-glycero-3-phosphocholine, 850457), DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine, 850375), cholesterol (700100), DLiPC (1,2-dilinoleoyl-sn-glycero-3-phosphocholine, 850385), DSPE-PEG(2000)-Biotin (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[biotinyl(polyethylene glycol)-2000] (ammonium salt), 880129) were purchased from Avanti Polar Lipids.

    Techniques: Fluorescence, Diffusion-based Assay, Membrane, Standard Deviation