microfluidic flow switch matrix  (Elveflow Inc)

Journal: PLoS ONE

Article Title: Creative problem solving and facial expressions: A stage based comparison

doi: 10.1371/journal.pone.0269504

Figure Lengend Snippet: Mean values of the stationary state distribution of the creative stages between the CPS and SPS groups.

Article Snippet: Using these probability matrices, a stationary state distribution matrix with one row and eight columns was created using R studio for each participant to represent the differences in cognitive effort exerted at different stages of the task solving process.

Techniques: Blocking Assay

Journal: PLoS ONE

Article Title: Creative problem solving and facial expressions: A stage based comparison

doi: 10.1371/journal.pone.0269504

Figure Lengend Snippet: Results of the Mann Whitney U test comparing the stationary state distribution of stages between the CPS and SPS groups.

Article Snippet: Using these probability matrices, a stationary state distribution matrix with one row and eight columns was created using R studio for each participant to represent the differences in cognitive effort exerted at different stages of the task solving process.

Techniques: MANN-WHITNEY, Blocking Assay

Journal: Micromachines

Article Title: Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control

doi: 10.3390/mi13050774

Figure Lengend Snippet: The Module-Fluidic generates the desired concentration profile that enables downstream microfluidic devices’ function.

Article Snippet: All the valves are controlled by a microfluidic valve control matrix (MUX QUAKE VALVE, Elveflow) with sixteen independent pressure outlets that can provide a constant pressure input when they are switched on.

Techniques: Concentration Assay

Journal: Micromachines

Article Title: Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control

doi: 10.3390/mi13050774

Figure Lengend Snippet: Structures of the Spatio-Temporal Concentration Controller. ( A ) 3D structure of Signal generator (Oscillator) and Module Connector (Integrator), the Oscillator consists of three layers, the PDMS structure layer has flow channels patterned. The channel is molded using positive photo resist which produces a semi-cylindrical cross-section for complete sealing of the micro valve. The second layer is a thin PDMS membrane with controlling valves when the air pressure (∼20 psi) is applied, valve will seal the channel. The third layer is glass slide to support the entire structure. All layers are bounded to each other using plasma bonding. The Integrator is a single microfluidic channel with depth 25 µm. The PDMS layer is also bounded to a glass slide; ( B ) Drawings of the oscillator and integrator ( C ) Concentration signal generation achieved by combination of valve status; ( D ) Function generated by the oscillator.

Article Snippet: All the valves are controlled by a microfluidic valve control matrix (MUX QUAKE VALVE, Elveflow) with sixteen independent pressure outlets that can provide a constant pressure input when they are switched on.

Techniques: Concentration Assay, Membrane, Clinical Proteomics, Generated

Journal: Lab on a chip

Article Title: Microfluidic platform for 3D cell culture with live imaging and clone retrieval.

doi: 10.1039/d0lc00165a

Figure Lengend Snippet: Fig. 3 Microfluidic platform for independent capture and release of aggregates. A. Schematic of the channel (bottom) layer of the microfluidic platform showing individual components and modules. (i) Shows individual bead traps, (ii) shows a magnified view of a secondary culture module. Insert shows cross-section of different channel regions. Thicker segments can be closed by valves. B. Schematic of the overlay of the valve and channel layer in the final design. C. Brightfield image of a cell, encapsulated in an agarose/fibrin/laminin bead, on the bead trap. D. Valve actuation and media flow for culture and live imaging. Media flow keeps all beads in position in the traps. E. By actuating a combination of valves (example shows extraction of bead in trap 8), the media flow along a single channel can be reversed, those allowing for the extraction of a bead of interest. Media flow is blocked along all other channels, so that all remaining beads remain in the traps. F. Snapshots of live imaging showing valve actuation (1), and re-direction of media by valve actuation as shown in (E) to removal of a single bead (false colour in green – steps 2–4). While a neighbouring bead (false colour blue) remains in position (4).

Article Snippet: Valve actuation is achieved through a pressure increase in the valve layer, which is controlled by a MUX microfluidic flow switch matrix (Elveflow), which can apply constant pressure over any combination of valves.

Techniques: Imaging, Extraction