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Hypogen Inc cat scramble program
Cat Scramble Program, supplied by Hypogen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/discovery+studios+catalyst+hypogen+algorithm/catalyst+hypogen+program/pmc07474860-146-5-12
Average 90 stars, based on 1 article reviews
cat scramble program - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Pharmacophore-driven identification of N-methyl-D-receptor antagonists as potent neuroprotective agents validated using in vivo studies
Article Snippet: With the help of the cat scramble program (available in the Catalyst HypoGen module), the biological activities of the chemical compounds in the training set were reviewed and employed for generating hypotheses.

Article Title: Development of pharmacophore similarity-based quantitative activity hypothesis and its applicability domain: applied on a diverse data-set of HIV-1 integrase inhibitors.
Article Snippet: Distinguishably, the activity residual (error as per Catalyst/HypoGen program (Catalyst, 2000)) for training set in CPH model (Mustata et al., 2004) is capricious in comparison to the observation of significant r2 and q2 values proposed by our SVM models.

Article Title: Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists.
Article Snippet: 0968-0896/$ see front matter 2010 Elsevier Ltd. A doi:10.1016/j.bmc.2010.06.047 * Corresponding author.. Tel./fax: +86 571 8882084 E-mail address: huyz@zju.edu.cn (Y. Hu).. The pharmacophore model (Hypo1) with a well prediction capacity for CysLT1 antagonists was developed using Catalyst/HypoGen program.

Article Title: Discovery of novel chemotype inhibitors targeting Anaplastic Lymphoma Kinase receptor through ligand-based pharmacophore modelling
Article Snippet: Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase within the insulin receptor superfamily.. Alterations in ALK, such as rearrangements, mutations, or amplifications, have been detected in various tumours, including lymphoma, neuroblastoma, and nonsmall cell lung cancer.. In this study, we outline a computational workflow designed to uncover new inhibitors of ALK.

Article Title: Discovery of novel potent nuclear factor kappa-B inhibitors (IKK-β) via extensive ligand-based modeling and virtual screening.
Article Snippet: J Mol Recognit 2016; e2604 DOI 10.1002/jmr.2604 Abstract Inhibitor kappa‐B kinase‐beta (IKK‐β) controls the activation of nuclear transcription factor kappa‐B and has been linked to inflammation and cancer.. Therefore, inhibitors of this kinase should have potent anti‐inflammatory and anticancer properties.. Accordingly, we explored the pharmacophoric space of 218 IKK‐β inhibitors to identify high‐quality binding models.

Activity Assay:

Article Title: Pharmacophore Elucidation and Molecular Docking Studies on 5-Phenyl-1-(3-pyridyl)-1 H -1,2,4-triazole-3-carboxylic Acid Derivatives as COX-2 Inhibitors
Article Snippet: .. The Catalyst program [ ] is generally used to analyze how ligands interact with a receptor by evaluating chemical features common to a set of active ligands (HipHop) [ ] or by elucidating the correlation between activity and chemical binding features (HypoGen) [ ]. ..

Binding Assay:

Article Title: Pharmacophore Elucidation and Molecular Docking Studies on 5-Phenyl-1-(3-pyridyl)-1 H -1,2,4-triazole-3-carboxylic Acid Derivatives as COX-2 Inhibitors
Article Snippet: .. The Catalyst program [ ] is generally used to analyze how ligands interact with a receptor by evaluating chemical features common to a set of active ligands (HipHop) [ ] or by elucidating the correlation between activity and chemical binding features (HypoGen) [ ]. ..



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Hypogen Inc discovery studio's catalyst hypogen algorithm
Discovery Studio's Catalyst Hypogen Algorithm, supplied by Hypogen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/discovery+studios+catalyst+hypogen+algorithm/discovery+studio+2+5/10__22270_slash_ujpr__v8i5__1008-60-1-4
Average 90 stars, based on 1 article reviews
discovery studio's catalyst hypogen algorithm - by Bioz Stars, 2026-09
90/100 stars
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