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α-difluoromethylornithine (dfmo)  (Hoechst Marion Roussel)

 
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    Hoechst Marion Roussel α-difluoromethylornithine (dfmo)
    α Difluoromethylornithine (Dfmo), supplied by Hoechst Marion Roussel, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dfmo/dfmo/pm29232652-46-20-29
    Average 90 stars, based on 1 article reviews
    α-difluoromethylornithine (dfmo) - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    other:

    Article Title: Effect of ornithine decarboxylase and norspermidine in modulating cell division in the green alga Chlamydomonas reinhardtii.
    Article Snippet: We would like to thank the Hoechst Marion Roussel Inc. (Cincinnati, OH, USA) for kindly supplying the DFMO and DFMA used in this study.


    Article Title: Human African trypanosomiasis: pharmacological re-engagement with a neglected disease
    Article Snippet: WHO were engaged in an apparently fruitless quest to find a manufacturer for eflornithine after Hoechst Marion Roussel (which was later incorporated into Aventis) had abandoned production in the 1990s.

    Article Title: Killer coma: the evolving story of sleeping sickness treatment
    Article Snippet: Efl ornithine was never profi table for the original manufacturer, Hoechst Marion Roussel, who stopped production in 1995.

    Article Title: 3-Aminooxy-1-Aminopropane and Derivatives Have an Antiproliferative Effect on Cultured Plasmodium falciparum by Decreasing Intracellular Polyamine Concentrations
    Article Snippet: DFMO and MDL 73811 were a kind gift from Hoechst Marion Roussel (Cincinnati, OH).

    Article Title: Effect of ornithine decarboxylase and norspermidine in modulating cell division in the green alga Chlamydomonas reinhardtii.
    Article Snippet: D,L-[1–14C] ornithine (specific activity, 56 mCi mmol−1) and L-[U-14C] arginine (specific activity, 303 mCi mmol−1) were purchased from Amersham, UK). α-Difluoromethylornithine (DFMO) and α−difluoromethylarginine (DFMA) were kindly supplied by Hoechst Marion Roussel (Ohio, USA).

    Article Title: Clinical trials as disease control? The political economy of sleeping sickness in the Democratic Republic of the Congo (1996-2016).
    Article Snippet: Adding to an already catastrophic situation, Hoechst Marion Roussel, the only producer of eflornithine globally, stopped producing the drug in 1995, claiming it was not profitable enough.

    Article Title: Polyamine synthesis inhibition induces S phase cell cycle arrest in vascular smooth muscle cells.
    Article Snippet: Polyamines are important for cell growth and proliferation and they are formed from arginine and ornithine via arginase and ornithine decarboxylase (ODC).. Arginine may alternatively be metabolised to NO via NO synthase.. Here we study if vascular smooth muscle cell proliferation can be reversed by polyamine synthesis inhibitors and investigate their mechanism of action.



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    (A) SK-N-BE(2)-c cells were treated with five doses of QW-5–70 (0.125 to 2 nM) in combination with five doses of <t>DFMO</t> (10–1000 μM). Cell viability was assessed using the MTS assay (n=4). (B) CI–Fa analysis of the QW-5–70 and DFMO combination. CI values were calculated using the Chou–Talalay median-effect method for five experimentally tested dose pairs at their corresponding Fa values. CI < 1, CI = 1, and CI > 1 indicate synergistic, additive, and antagonistic interactions, respectively. (C) SK-N-BE(2)-c cells were treated with five doses of QW-5–70 (0.125 to 2 nM) in combination with five doses of MLN8237 (1–100 nM). Cell viability was assessed using the MTS assay (n=4). (D) SK-N-BE(2)-C cells were treated with 1 nM QW-5–70 in combination with either DFMO (300 μM, top) or MLN8237 (30 nM, bottom) as indicated. Cell lysates were analyzed by immunoblotting for cPARP as a marker of apoptosis, with GAPDH used as a loading control. (E) Representative colony formation images of SK-N-BE(2)-C cells treated with the same combination. Colony formations were quantified and expressed as mean ± SEM relative to vehicle (set to 100%) (n=5).
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    (A) SK-N-BE(2)-c cells were treated with five doses of QW-5–70 (0.125 to 2 nM) in combination with five doses of DFMO (10–1000 μM). Cell viability was assessed using the MTS assay (n=4). (B) CI–Fa analysis of the QW-5–70 and DFMO combination. CI values were calculated using the Chou–Talalay median-effect method for five experimentally tested dose pairs at their corresponding Fa values. CI < 1, CI = 1, and CI > 1 indicate synergistic, additive, and antagonistic interactions, respectively. (C) SK-N-BE(2)-c cells were treated with five doses of QW-5–70 (0.125 to 2 nM) in combination with five doses of MLN8237 (1–100 nM). Cell viability was assessed using the MTS assay (n=4). (D) SK-N-BE(2)-C cells were treated with 1 nM QW-5–70 in combination with either DFMO (300 μM, top) or MLN8237 (30 nM, bottom) as indicated. Cell lysates were analyzed by immunoblotting for cPARP as a marker of apoptosis, with GAPDH used as a loading control. (E) Representative colony formation images of SK-N-BE(2)-C cells treated with the same combination. Colony formations were quantified and expressed as mean ± SEM relative to vehicle (set to 100%) (n=5).

    Journal: Molecular cancer therapeutics

    Article Title: QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp–overexpressing cancer models

    doi: 10.1158/1535-7163.MCT-25-1013

    Figure Lengend Snippet: (A) SK-N-BE(2)-c cells were treated with five doses of QW-5–70 (0.125 to 2 nM) in combination with five doses of DFMO (10–1000 μM). Cell viability was assessed using the MTS assay (n=4). (B) CI–Fa analysis of the QW-5–70 and DFMO combination. CI values were calculated using the Chou–Talalay median-effect method for five experimentally tested dose pairs at their corresponding Fa values. CI < 1, CI = 1, and CI > 1 indicate synergistic, additive, and antagonistic interactions, respectively. (C) SK-N-BE(2)-c cells were treated with five doses of QW-5–70 (0.125 to 2 nM) in combination with five doses of MLN8237 (1–100 nM). Cell viability was assessed using the MTS assay (n=4). (D) SK-N-BE(2)-C cells were treated with 1 nM QW-5–70 in combination with either DFMO (300 μM, top) or MLN8237 (30 nM, bottom) as indicated. Cell lysates were analyzed by immunoblotting for cPARP as a marker of apoptosis, with GAPDH used as a loading control. (E) Representative colony formation images of SK-N-BE(2)-C cells treated with the same combination. Colony formations were quantified and expressed as mean ± SEM relative to vehicle (set to 100%) (n=5).

    Article Snippet: Paclitaxel was purchased from LC Laboratories; colchicine and verapamil from Sigma; and Q-VD-OPh (QVD), tariquidar, DFMO (eflornithine), and MLN8237 from MedChemExpress.

    Techniques: Activity Assay, MTS Assay, Western Blot, Marker, Control