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Lantheus Medical Imaging definitytm microbubble contrast agent
Definitytm Microbubble Contrast Agent, supplied by Lantheus Medical Imaging, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/definitytm+microbubbles/microbubble+contrast+definity/us10258314-48-14-18
Average 90 stars, based on 1 article reviews
definitytm microbubble contrast agent - by Bioz Stars, 2026-10
90/100 stars

Images

Related Articles

Imaging:

Article Title: Role of perfusion imaging in diagnosing myxoma mimics
Article Snippet: However, colour-flow Doppler echocardiography and contrast echocardiography (Definity contrast microbubbles, Lantheus Medical Imaging, North Billerica, MA, USA) showed an absence of vascular channels through the mass and no evidence of myxoma blush ( Panels C and D ; see Supplementary data online, Movies S3 and S4 ).

Article Title: Imaging microvasculature with contrast-enhanced ultraharmonic ultrasound.
Article Snippet: DAVID MARESCA,* ILYA SKACHKOV,* GUILLAUME RENAUD,* KRISTA JANSEN,*y GIJS VAN SOEST,* NICO DE JONG,*yz and ANTONIUS F. W. VAN DER STEEN*yz *Biomedical Engineering Department, Thorax Centre, Erasmus University Medical Centre, Rotterdam, The Netherlands; y Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands; and z Imaging Science and Technology Department, Delft University of Technology, Delft, The Netherlands

Article Title: Systems and methods for super-resolution ultrasound imaging
Article Snippet: An example of a contrast agent suitable for the purposes described here is the DefinityTM microbubble contrast agent (Lantheus Medical Imaging, North Billerica, Mass., USA), which includes microbubbles with a mean diameter of 1-3 μm.

Article Title: Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy.
Article Snippet: Definity® bubbles were activated as instructed by the manufacturer using a Vialmix® (Lantheus Medical Imaging Inc., N. Billerica, MA) for 45 s. According to the manufacturer, this resulted in the formation of microbubbles with a mean diameter ranging from 1.1 μm to 3.3 μm and a maximum diameter of 20 μm.

Article Title: A simple technique for bedside estimation of left atrial pressure.
Article Snippet: Dyspnea is one of the most commonly encountered symptoms, both in the outpatient setting and among hospitalized patients.. Distinguishing between cardiac and pulmonary causes can be diffi‐ cult and remains imprecise.. For this reason, much investigation has been done into ways to accurately estimate left atrial pressure (LAP).

Article Title: The Effect of Short Duration Ultrasound Pulses on the Interaction Between Individual Microbubbles and Fibrin Clots.
Article Snippet: A Resear Canada Abstract—In previous work, we examined microscale interactions between microbubbles and fibrin clots under exposure to 1 ms ultrasound pulses.. This provided direct evidence that microbubbles were capable of deforming clot boundaries and penetrating into clots, while also affecting fluid uptake and inducing fibrin network damage.. Here, we investigate the effect of short duration (15 ms) pulses on microscale bubble-clot interactions as function of bubble diameter (3–9 mm) and pressure.

Injection:

Article Title: Role of perfusion imaging in diagnosing myxoma mimics
Article Snippet: However, colour-flow Doppler echocardiography and contrast echocardiography (Definity contrast microbubbles, Lantheus Medical Imaging, North Billerica, MA, USA) showed an absence of vascular channels through the mass and no evidence of myxoma blush ( Panels C and D ; see Supplementary data online, Movies S3 and S4 ).

Article Title: Imaging microvasculature with contrast-enhanced ultraharmonic ultrasound.
Article Snippet: DAVID MARESCA,* ILYA SKACHKOV,* GUILLAUME RENAUD,* KRISTA JANSEN,*y GIJS VAN SOEST,* NICO DE JONG,*yz and ANTONIUS F. W. VAN DER STEEN*yz *Biomedical Engineering Department, Thorax Centre, Erasmus University Medical Centre, Rotterdam, The Netherlands; y Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands; and z Imaging Science and Technology Department, Delft University of Technology, Delft, The Netherlands

Article Title: Systems and methods for super-resolution ultrasound imaging
Article Snippet: An example of a contrast agent suitable for the purposes described here is the DefinityTM microbubble contrast agent (Lantheus Medical Imaging, North Billerica, Mass., USA), which includes microbubbles with a mean diameter of 1-3 μm.

Article Title: Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy.
Article Snippet: Definity® bubbles were activated as instructed by the manufacturer using a Vialmix® (Lantheus Medical Imaging Inc., N. Billerica, MA) for 45 s. According to the manufacturer, this resulted in the formation of microbubbles with a mean diameter ranging from 1.1 μm to 3.3 μm and a maximum diameter of 20 μm.

Article Title: A simple technique for bedside estimation of left atrial pressure.
Article Snippet: Dyspnea is one of the most commonly encountered symptoms, both in the outpatient setting and among hospitalized patients.. Distinguishing between cardiac and pulmonary causes can be diffi‐ cult and remains imprecise.. For this reason, much investigation has been done into ways to accurately estimate left atrial pressure (LAP).

Article Title: The Effect of Short Duration Ultrasound Pulses on the Interaction Between Individual Microbubbles and Fibrin Clots.
Article Snippet: A Resear Canada Abstract—In previous work, we examined microscale interactions between microbubbles and fibrin clots under exposure to 1 ms ultrasound pulses.. This provided direct evidence that microbubbles were capable of deforming clot boundaries and penetrating into clots, while also affecting fluid uptake and inducing fibrin network damage.. Here, we investigate the effect of short duration (15 ms) pulses on microscale bubble-clot interactions as function of bubble diameter (3–9 mm) and pressure.

Modification:

Article Title: Role of perfusion imaging in diagnosing myxoma mimics
Article Snippet: However, colour-flow Doppler echocardiography and contrast echocardiography (Definity contrast microbubbles, Lantheus Medical Imaging, North Billerica, MA, USA) showed an absence of vascular channels through the mass and no evidence of myxoma blush ( Panels C and D ; see Supplementary data online, Movies S3 and S4 ).

Article Title: Imaging microvasculature with contrast-enhanced ultraharmonic ultrasound.
Article Snippet: DAVID MARESCA,* ILYA SKACHKOV,* GUILLAUME RENAUD,* KRISTA JANSEN,*y GIJS VAN SOEST,* NICO DE JONG,*yz and ANTONIUS F. W. VAN DER STEEN*yz *Biomedical Engineering Department, Thorax Centre, Erasmus University Medical Centre, Rotterdam, The Netherlands; y Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands; and z Imaging Science and Technology Department, Delft University of Technology, Delft, The Netherlands

Article Title: Systems and methods for super-resolution ultrasound imaging
Article Snippet: An example of a contrast agent suitable for the purposes described here is the DefinityTM microbubble contrast agent (Lantheus Medical Imaging, North Billerica, Mass., USA), which includes microbubbles with a mean diameter of 1-3 μm.

Article Title: Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy.
Article Snippet: Definity® bubbles were activated as instructed by the manufacturer using a Vialmix® (Lantheus Medical Imaging Inc., N. Billerica, MA) for 45 s. According to the manufacturer, this resulted in the formation of microbubbles with a mean diameter ranging from 1.1 μm to 3.3 μm and a maximum diameter of 20 μm.

Article Title: A simple technique for bedside estimation of left atrial pressure.
Article Snippet: Dyspnea is one of the most commonly encountered symptoms, both in the outpatient setting and among hospitalized patients.. Distinguishing between cardiac and pulmonary causes can be diffi‐ cult and remains imprecise.. For this reason, much investigation has been done into ways to accurately estimate left atrial pressure (LAP).

Article Title: The Effect of Short Duration Ultrasound Pulses on the Interaction Between Individual Microbubbles and Fibrin Clots.
Article Snippet: A Resear Canada Abstract—In previous work, we examined microscale interactions between microbubbles and fibrin clots under exposure to 1 ms ultrasound pulses.. This provided direct evidence that microbubbles were capable of deforming clot boundaries and penetrating into clots, while also affecting fluid uptake and inducing fibrin network damage.. Here, we investigate the effect of short duration (15 ms) pulses on microscale bubble-clot interactions as function of bubble diameter (3–9 mm) and pressure.

Saline:

Article Title: Role of perfusion imaging in diagnosing myxoma mimics
Article Snippet: However, colour-flow Doppler echocardiography and contrast echocardiography (Definity contrast microbubbles, Lantheus Medical Imaging, North Billerica, MA, USA) showed an absence of vascular channels through the mass and no evidence of myxoma blush ( Panels C and D ; see Supplementary data online, Movies S3 and S4 ).

Article Title: Imaging microvasculature with contrast-enhanced ultraharmonic ultrasound.
Article Snippet: DAVID MARESCA,* ILYA SKACHKOV,* GUILLAUME RENAUD,* KRISTA JANSEN,*y GIJS VAN SOEST,* NICO DE JONG,*yz and ANTONIUS F. W. VAN DER STEEN*yz *Biomedical Engineering Department, Thorax Centre, Erasmus University Medical Centre, Rotterdam, The Netherlands; y Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands; and z Imaging Science and Technology Department, Delft University of Technology, Delft, The Netherlands

Article Title: Systems and methods for super-resolution ultrasound imaging
Article Snippet: An example of a contrast agent suitable for the purposes described here is the DefinityTM microbubble contrast agent (Lantheus Medical Imaging, North Billerica, Mass., USA), which includes microbubbles with a mean diameter of 1-3 μm.

Article Title: Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy.
Article Snippet: Definity® bubbles were activated as instructed by the manufacturer using a Vialmix® (Lantheus Medical Imaging Inc., N. Billerica, MA) for 45 s. According to the manufacturer, this resulted in the formation of microbubbles with a mean diameter ranging from 1.1 μm to 3.3 μm and a maximum diameter of 20 μm.

Article Title: A simple technique for bedside estimation of left atrial pressure.
Article Snippet: Dyspnea is one of the most commonly encountered symptoms, both in the outpatient setting and among hospitalized patients.. Distinguishing between cardiac and pulmonary causes can be diffi‐ cult and remains imprecise.. For this reason, much investigation has been done into ways to accurately estimate left atrial pressure (LAP).

Article Title: The Effect of Short Duration Ultrasound Pulses on the Interaction Between Individual Microbubbles and Fibrin Clots.
Article Snippet: A Resear Canada Abstract—In previous work, we examined microscale interactions between microbubbles and fibrin clots under exposure to 1 ms ultrasound pulses.. This provided direct evidence that microbubbles were capable of deforming clot boundaries and penetrating into clots, while also affecting fluid uptake and inducing fibrin network damage.. Here, we investigate the effect of short duration (15 ms) pulses on microscale bubble-clot interactions as function of bubble diameter (3–9 mm) and pressure.



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Lantheus Medical Imaging microbubbles definitytm
(a) Lateral (top row) and axial (bottom row) images of <t>microbubble</t> clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.
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Image Search Results


(a) Lateral (top row) and axial (bottom row) images of microbubble clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.

Journal: Physics in medicine and biology

Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

doi: 10.1088/0031-9155/61/24/8476

Figure Lengend Snippet: (a) Lateral (top row) and axial (bottom row) images of microbubble clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.

Article Snippet: The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (DefinityTM, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).

Techniques: In Situ, Ex Vivo, Generated

(a). Contrast-enhanced T1-weighted MR image of the rat taken with contrast following FUS+microbubbles (MBs). (b). Corresponding passive acoustic maps from the burst 30 s into the sonication for sonications with MBs and BBB opening. The lateral plane of maximum intensity pixel projection is shown. (c) Frequency spectrum of the beamformed signal at the point of maximum intensity in (b) is given.

Journal: Physics in medicine and biology

Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

doi: 10.1088/0031-9155/61/24/8476

Figure Lengend Snippet: (a). Contrast-enhanced T1-weighted MR image of the rat taken with contrast following FUS+microbubbles (MBs). (b). Corresponding passive acoustic maps from the burst 30 s into the sonication for sonications with MBs and BBB opening. The lateral plane of maximum intensity pixel projection is shown. (c) Frequency spectrum of the beamformed signal at the point of maximum intensity in (b) is given.

Article Snippet: The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (DefinityTM, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).

Techniques: Sonication