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perfluoropropane microbubbles  (Lantheus Medical Imaging)

 
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    Lantheus Medical Imaging perfluoropropane microbubbles
    COSDUM of stable cavitation in insonated <t>microbubbles.</t> a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked by the cyan dashed cuboid). b Quantification of the time-resolved radius (red solid line) and the wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line) of the microbubble. c Power spectrum of the time-resolved radius extracted from (b). d Angular distribution of microbubble radius at rest and at peak expansion over 10 cycles. e–h Quantification of the expansion ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{e}}$$\end{document} r e (e), the compression ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{c}}$$\end{document} r c (f), the oscillation asymmetry \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{a}}$$\end{document} r a (g), and maximum wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{mw}}$$\end{document} v mw (h) across 17 measured microbubbles. The red dotted curves in (e)–(g) were obtained by fitting the experimental data with a fourth-order polynomial. The red dotted curve in (h) was obtained by linear regression fitting
    Perfluoropropane Microbubbles, supplied by Lantheus Medical Imaging, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/definitytm+microbubbles/microbubbles/pmc13133243-182-1-3
    Average 86 stars, based on 1 article reviews
    perfluoropropane microbubbles - by Bioz Stars, 2026-10
    86/100 stars

    Images

    1) Product Images from "Computational optical streak microscopy of megahertz acoustic microbubble dynamics"

    Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

    Journal: Photonix

    doi: 10.1186/s43074-026-00232-8

    COSDUM of stable cavitation in insonated microbubbles. a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked by the cyan dashed cuboid). b Quantification of the time-resolved radius (red solid line) and the wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line) of the microbubble. c Power spectrum of the time-resolved radius extracted from (b). d Angular distribution of microbubble radius at rest and at peak expansion over 10 cycles. e–h Quantification of the expansion ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{e}}$$\end{document} r e (e), the compression ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{c}}$$\end{document} r c (f), the oscillation asymmetry \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{a}}$$\end{document} r a (g), and maximum wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{mw}}$$\end{document} v mw (h) across 17 measured microbubbles. The red dotted curves in (e)–(g) were obtained by fitting the experimental data with a fourth-order polynomial. The red dotted curve in (h) was obtained by linear regression fitting
    Figure Legend Snippet: COSDUM of stable cavitation in insonated microbubbles. a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked by the cyan dashed cuboid). b Quantification of the time-resolved radius (red solid line) and the wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line) of the microbubble. c Power spectrum of the time-resolved radius extracted from (b). d Angular distribution of microbubble radius at rest and at peak expansion over 10 cycles. e–h Quantification of the expansion ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{e}}$$\end{document} r e (e), the compression ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{c}}$$\end{document} r c (f), the oscillation asymmetry \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{a}}$$\end{document} r a (g), and maximum wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{mw}}$$\end{document} v mw (h) across 17 measured microbubbles. The red dotted curves in (e)–(g) were obtained by fitting the experimental data with a fourth-order polynomial. The red dotted curve in (h) was obtained by linear regression fitting

    Techniques Used:

    COSDUM of the collapse of an insonated microbubble. a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked as the cyan dashed cuboid). b Quantification of the radial profile of the microbubble over time (red solid line) with its radial wall velocity profile \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line). c Radial power spectrum extracted from ( b )
    Figure Legend Snippet: COSDUM of the collapse of an insonated microbubble. a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked as the cyan dashed cuboid). b Quantification of the radial profile of the microbubble over time (red solid line) with its radial wall velocity profile \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line). c Radial power spectrum extracted from ( b )

    Techniques Used:

    COSDUM of microbubble-platelet interactions in whole blood. a Representative reconstructed frames showing the periodic motion of a platelet driven by an uncontacted microbubble. b Close-up view of the platelet during three representative oscillation cycles. c Quantification of the radial profile of the microbubble over time. d–e Central position of the platelet along the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$x$$\end{document} x - and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$y$$\end{document} y -axes, respectively
    Figure Legend Snippet: COSDUM of microbubble-platelet interactions in whole blood. a Representative reconstructed frames showing the periodic motion of a platelet driven by an uncontacted microbubble. b Close-up view of the platelet during three representative oscillation cycles. c Quantification of the radial profile of the microbubble over time. d–e Central position of the platelet along the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$x$$\end{document} x - and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$y$$\end{document} y -axes, respectively

    Techniques Used:

    COSDUM of microbubble-red blood cell (RBC) interactions in whole blood. a Representative reconstructed frames showing the shape-adapted expansion of a microbubble around an adjacent RBC, resulting in a contact surface of approximately 25% of the RBC. b Microbubble radius as a function of angle and time. c 2D projected area of the microbubble over time, highlighting periodic oscillations and inter-cycle variations
    Figure Legend Snippet: COSDUM of microbubble-red blood cell (RBC) interactions in whole blood. a Representative reconstructed frames showing the shape-adapted expansion of a microbubble around an adjacent RBC, resulting in a contact surface of approximately 25% of the RBC. b Microbubble radius as a function of angle and time. c 2D projected area of the microbubble over time, highlighting periodic oscillations and inter-cycle variations

    Techniques Used:

    Related Articles

    Magnetic Resonance Imaging:

    Article Title: Noninvasive enrichment of circulating tumor biomarkers in a mouse model of diffuse midline glioma using focused ultrasound
    Article Snippet: Before FUS treatment, contrast-enhanced T 1 -weighted MRI scans were performed after intravenous administration of the MRI contrast agent gadoterate meglumine (dose of 1 mL/kg, Gd-DOTA; Dotarem, Guerbet, Aulnay sous Bois, France) to assess the BBB permeability of the DMG tumor before FUS sonication. .. After the MRI scan, FUS sonication was turned on, followed by intravenously administering microbubbles (Definity, Lantheus Medical Imaging, North Billerica, MA, USA) at a dose of 100 μL/kg. ..

    Sonication:

    Article Title: Noninvasive enrichment of circulating tumor biomarkers in a mouse model of diffuse midline glioma using focused ultrasound
    Article Snippet: Before FUS treatment, contrast-enhanced T 1 -weighted MRI scans were performed after intravenous administration of the MRI contrast agent gadoterate meglumine (dose of 1 mL/kg, Gd-DOTA; Dotarem, Guerbet, Aulnay sous Bois, France) to assess the BBB permeability of the DMG tumor before FUS sonication. .. After the MRI scan, FUS sonication was turned on, followed by intravenously administering microbubbles (Definity, Lantheus Medical Imaging, North Billerica, MA, USA) at a dose of 100 μL/kg. ..

    Sterility:

    Article Title: Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.
    Article Snippet: tFUS positioning software (Morpheus framework; FUS Instruments Incorporated, Toronto, ON, Canada), which incorporates the marmosetbrainconnectome. .. Immediately prior to insonication, a bolus of lipid microbubbles (350 μL/kg; Definity, Lantheus Medical Imaging, Billerica, MA, USA) - prepared by mixing 0.86 mL of sterile saline with 0.1 mL of microbubbles - was administered via the implanted catheter to aid in BBB disruption. ..

    Saline:

    Article Title: Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.
    Article Snippet: tFUS positioning software (Morpheus framework; FUS Instruments Incorporated, Toronto, ON, Canada), which incorporates the marmosetbrainconnectome. .. Immediately prior to insonication, a bolus of lipid microbubbles (350 μL/kg; Definity, Lantheus Medical Imaging, Billerica, MA, USA) - prepared by mixing 0.86 mL of sterile saline with 0.1 mL of microbubbles - was administered via the implanted catheter to aid in BBB disruption. ..

    Disruption:

    Article Title: Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.
    Article Snippet: tFUS positioning software (Morpheus framework; FUS Instruments Incorporated, Toronto, ON, Canada), which incorporates the marmosetbrainconnectome. .. Immediately prior to insonication, a bolus of lipid microbubbles (350 μL/kg; Definity, Lantheus Medical Imaging, Billerica, MA, USA) - prepared by mixing 0.86 mL of sterile saline with 0.1 mL of microbubbles - was administered via the implanted catheter to aid in BBB disruption. ..

    Imaging:

    Article Title: Cardiac allograft vasculopathy diagnosed by vasodilator myocardial contrast echocardiography perfusion imaging.
    Article Snippet: .. We utilized regadenoson given fewer side effects compared with other vasodilators.7 Power modulation imaging was performed during a continuous infusion of lipid-stabilized octafluoropropane microbubbles (Definity, Lantheus Medical Imaging). ..

    Injection:

    Article Title: 12 th International Stereotactic Radiosurgery Society Congress (ISRS 2015)
    Article Snippet: .. Microbubbles (Lantheus Medical) were injected through the tail-vein resulting in a blood volume concentration of 1 % or 3 % (v/v). ..

    Article Title: [2208.03429] High-level synthesis design of scalable ultrafast ultrasound beamformer with single FPGA
    Article Snippet: As a second test, a mouse brain was scanned with a Verasonics L35-16vX probe. .. The mouse was injected with microbubbles (Definity, Lantheus Medical Imaging, Inc.) to conduct super-resolution ULM of the mouse brain and to evaluate the speed of our beamformer. ..

    Article Title: In vivo two-photon microscopy imaging of focused ultrasound-mediated glymphatic transport in the mouse brain
    Article Snippet: .. Microbubbles (Definity, Lantheus Medical Imaging, N. Billerica, MA, USA) were intravenously administered to the mouse through a bolus injection. .. The size of microbubbles was 1.34 0.28mm in diameter, measured by a cell counter (Countless 2, Thermo Fisher Scientific, Waltham, MA, USA).

    Concentration Assay:

    Article Title: 12 th International Stereotactic Radiosurgery Society Congress (ISRS 2015)
    Article Snippet: .. Microbubbles (Lantheus Medical) were injected through the tail-vein resulting in a blood volume concentration of 1 % or 3 % (v/v). ..

    Suspension:

    Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics
    Article Snippet: .. Encapsulated perfluoropropane microbubbles (Lantheus Medical Imaging, DefinityTM) were first diluted by adding one drop of the commercial microbubble suspension into a 1.5-mL microcentrifuge tube containing distilled water and were then gently mixed to ensure uniform dispersion. ..

    Dispersion:

    Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics
    Article Snippet: .. Encapsulated perfluoropropane microbubbles (Lantheus Medical Imaging, DefinityTM) were first diluted by adding one drop of the commercial microbubble suspension into a 1.5-mL microcentrifuge tube containing distilled water and were then gently mixed to ensure uniform dispersion. ..



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    (a) Lateral (top row) and axial (bottom row) images of <t>microbubble</t> clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.
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    Image Search Results


    (a) Lateral (top row) and axial (bottom row) images of microbubble clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.

    Journal: Physics in medicine and biology

    Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

    doi: 10.1088/0031-9155/61/24/8476

    Figure Lengend Snippet: (a) Lateral (top row) and axial (bottom row) images of microbubble clouds located near the array's geometric focus reconstructed at 306 kHz (0.53 MPa estimated in-situ pressure), 612 kHz (0.27 MPa estimated in-situ pressure), and 1.224 MHz (0.23 MPa estimated in-situ pressure), respectively, through an ex-vivo human skullcap using source-based aberration corrections. Please note that the scale bars used in each sub plot in figure 10(a) are different. (b) Frequency spectrum of the beamformed signal at the point of maximum intensity is given for each of the cases in (a). (c) Normalized maximum pixel projection images of the tube phantom obtained through an ex-vivo human skullcap. Images were captured at both the half-harmonic (612 kHz transmit frequency, 0.53 MPa estimated in-situ pressure) and the second-harmonic (306 kHz transmit frequency, 0.27 MPa estimated in-situ pressure), and were reconstructed with and without the use of source-based aberration corrections on receive. The cross-sectional images (bottom row) were generated by taking the maximum pixel projection over the range of [−1,1] mm in Y.

    Article Snippet: The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (DefinityTM, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).

    Techniques: In Situ, Ex Vivo, Generated

    (a). Contrast-enhanced T1-weighted MR image of the rat taken with contrast following FUS+microbubbles (MBs). (b). Corresponding passive acoustic maps from the burst 30 s into the sonication for sonications with MBs and BBB opening. The lateral plane of maximum intensity pixel projection is shown. (c) Frequency spectrum of the beamformed signal at the point of maximum intensity in (b) is given.

    Journal: Physics in medicine and biology

    Article Title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping

    doi: 10.1088/0031-9155/61/24/8476

    Figure Lengend Snippet: (a). Contrast-enhanced T1-weighted MR image of the rat taken with contrast following FUS+microbubbles (MBs). (b). Corresponding passive acoustic maps from the burst 30 s into the sonication for sonications with MBs and BBB opening. The lateral plane of maximum intensity pixel projection is shown. (c) Frequency spectrum of the beamformed signal at the point of maximum intensity in (b) is given.

    Article Snippet: The receiving capabilities of the array were investigated by imaging ultrasound-stimulated microbubbles (DefinityTM, Lantheus Medical Imaging, North Billerica, MA, USA) flowing through thin-walled tube phantoms (Cole-Parmer, Vernon Hills, IL, USA).

    Techniques: Sonication