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deep sequencing microarray  (Johns Hopkins HealthCare)

 
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    Johns Hopkins HealthCare deep sequencing microarray
    Analysis of global gene expression in Krt16-null footpad lesions and comparison to human PC cases. (A) Volcano plot depicting differentially expressed genes in Krt16-null paw skin lesions relative to WT controls. (B) Top 10 genes differentially regulated in Krt16-null paw skin from established paw lesions compared to WT littermate controls. (C) Validation of downregulated genes identified by <t>microarray</t> analysis by RT-qPCR in Krt16-null paw skin lesions. N = 4 mice/genotype. Error bars are SEM. *P < 0.05, **P < 0.01. (D) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT16 human cases. (E) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT16 human cases. (F) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT6 human cases. (G) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT6 human cases. Boxes for (D)–(G) list common genes between mouse and human data sets (listed in alphabetical order).
    Deep Sequencing Microarray, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/deep+sequencing+and+microarray+core/pmc06602407-531-41-39?v=Johns+Hopkins+HealthCare
    Average 90 stars, based on 1 article reviews
    deep sequencing microarray - by Bioz Stars, 2026-08
    90/100 stars

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    1) Product Images from "Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma"

    Article Title: Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma

    Journal: Human Molecular Genetics

    doi: 10.1093/hmg/ddz050

    Analysis of global gene expression in Krt16-null footpad lesions and comparison to human PC cases. (A) Volcano plot depicting differentially expressed genes in Krt16-null paw skin lesions relative to WT controls. (B) Top 10 genes differentially regulated in Krt16-null paw skin from established paw lesions compared to WT littermate controls. (C) Validation of downregulated genes identified by microarray analysis by RT-qPCR in Krt16-null paw skin lesions. N = 4 mice/genotype. Error bars are SEM. *P < 0.05, **P < 0.01. (D) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT16 human cases. (E) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT16 human cases. (F) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT6 human cases. (G) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT6 human cases. Boxes for (D)–(G) list common genes between mouse and human data sets (listed in alphabetical order).
    Figure Legend Snippet: Analysis of global gene expression in Krt16-null footpad lesions and comparison to human PC cases. (A) Volcano plot depicting differentially expressed genes in Krt16-null paw skin lesions relative to WT controls. (B) Top 10 genes differentially regulated in Krt16-null paw skin from established paw lesions compared to WT littermate controls. (C) Validation of downregulated genes identified by microarray analysis by RT-qPCR in Krt16-null paw skin lesions. N = 4 mice/genotype. Error bars are SEM. *P < 0.05, **P < 0.01. (D) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT16 human cases. (E) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT16 human cases. (F) Overlap in the significantly changed genes that are upregulated between Krt16-null paw skin lesions and KRT6 human cases. (G) Overlap in the significantly changed genes that are downregulated between Krt16-null paw skin lesions and KRT6 human cases. Boxes for (D)–(G) list common genes between mouse and human data sets (listed in alphabetical order).

    Techniques Used: Gene Expression, Comparison, Biomarker Discovery, Microarray, Quantitative RT-PCR



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