monoclonal anti-d reagents d-screen (Diagast Inc)
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monoclonal anti-d reagents d-screen
Monoclonal Anti D Reagents D Screen, supplied by Diagast Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/d+screen/monoclonal+anti+d+d+screen/pm40389221-75-13-16
Average 90 stars, based on 1 article reviews
Monoclonal Anti D Reagents D Screen, supplied by Diagast Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/d+screen/monoclonal+anti+d+d+screen/pm40389221-75-13-16
Average 90 stars, based on 1 article reviews
monoclonal anti-d reagents d-screen - by Bioz Stars,
2026-10
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Agglutination:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. Saline:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. Diagnostic Assay:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. Transfection:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. Expressing:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. Flow Cytometry:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. Bioprocessing:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. Clone Assay:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. Adsorption:Article Title: A new RHD variant allele (RHD Gly339Val) shows weakened D expression compared to RHD Gly339Glu and Gly339Arg mutants. Article Snippet: W e report a new RHD variant allele (RHD 1016G>T, Gly339Val, GenBank Accession No. MF737523, ISBT nomenclature RHD*DEL49.) that was discovered in a Korean male hepatocellular carcinoma patient.. We have performed epitope mapping of the D antigen and analyzed the expected effect of this variation with comparison to two other D weak–expressing variants with an amino acid change in the same position.. Pretransfusion testing of D blood group was performed: two commercial anti-D reagents (Ortho Clinical Diagnostics and Millipore) were used for D and weak-D typing, and results indicated no reactions in both routine D and weak-D testing. Article Title: The 30th Regional Congress of the ISBT, Bangkok, Thailand, 16-19 Nov, 2019. Article Snippet: RhD phenotyping was initially routinely performed using two monoclonal anti-D reagents (Clone Rum-1, IgM; Clone TH-28/MS26, IgM/IgG), and then tested using a commercial panel of monoclonal Article Title: Molecular and serological analysis of the D variant in the Chinese population and identification of seven novel RHD alleles. Article Snippet: Funding information Guangdong Basic and Applied Basic Research Foundation, Grant/Award Numbers: 2021A1515012139, 2021A1515012532; National Natural Science Foundation of China, Grant/Award Numbers: 81900184, 82070198; The Key Medical Disciplines and Specialties Program of Guangzhou (2021-2023), Guangdong, China Abstract Background: The molecular basis of the D variant phenotype in the Chinese differs greatly from that of the Caucasian.. Adapting a specific D typing strategy to the spectrum of prevalent RHD variant alleles is necessary.. Study Design and Methods: Blood samples with ambiguous D phenotypes were collected in the Southern Chinese population. Article Title: Abstracts of the 37th International Congress of the ISBT, Virtual meeting, 4-8 June 2022. Article Snippet: Further RH1 antigen characterization included an anti-RH1 antibody panel containing nine Article Title: The need for routine detection of the Asian-type DEL allele in individuals with weak or partial D phenotypes from East and Southeast Asian populations. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Number: 82470233; Science and Technology Projects in Guangzhou, Grant/Award Numbers: 202201011823, 2024A03J0442, 2023A03J0545, 2023A03J0552; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2024A1515012995 Abstract Background and Objectives: Among the rare serologically D-negative (D ) individuals in Asia, those carrying the Asian-type DEL allele (RHD*DEL1) can be safely managed as D+ individuals during transfusion and pregnancy.. Recently, some individuals carrying RHD*DEL1, who exhibit serologically weak/partial D phenotypes rather than the serologically D phenotype, have also been described.. Whether anti-D alloimmunization can occur among them was explored. Article Title: The 36th International ISBT Congress, Virtual meeting, 12-16 December 2020. Article Snippet: The serological characteristic for the epitope of D antigen was further analyzed by using the commercial Article Title: RHD alleles contributing to serologically weak D phenotypes in China: A single-centre study over 10 years. Article Snippet: Funding information National Natural Science Foundation of China, Grant/Award Numbers: 30371312, 81970168; Research Foundation of Shanghai Municipal Health Commission, China, Grant/ Award Number: 201940442 Abstract Background and Objectives: In cases of serologically weak D phenotypes, RHD genotyping may identify discrepant serotyping results and protect the patient against allogeneic immunization.. This study aimed to conduct a comprehensive analysis of weak D alleles in China.. Materials and Methods: We collected samples carrying weak D antigen during a 10-year period from 2005 to 2014. Article Title: Reduced RhD antigen expression caused by two novel RHD variant alleles. Article Snippet: R outine donor screening revealed ambiguous results for RhD blood group typing in two donors.. Donor 1, serologically typed as RhD negative, was positive for exon 3/5 and 10 in routine RHD screening as performed for all RhD-negative donors in Switzerland.. Donor 2 displayed an unusual reaction pattern with the Combi Anti-D Mono-Type antisera (clones LDM3 and ESD1) from Medion Grifols Switzerland. |