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Umetrics cross validation tool simca p software
Cross Validation Tool Simca P Software, supplied by Umetrics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cross+validation/p+simca+software+%C3%BE/pm41825490-109-3-9
Average 86 stars, based on 1 article reviews
cross validation tool simca p software - by Bioz Stars, 2026-11
86/100 stars

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Software:

Article Title: Revealing the enhancing mechanism and material basis of bile-processed Coptidis Rhizoma in anti-anxiety from perspective of cross organ regulation.
Article Snippet: Ethnopharmacological relevance: Coptidis Rhizoma (CR) is a typical cold-attribute herb with potential anti-anxiety properties.. Bile is of cold nature and can also interfere with the central nervous system.. Bile-processed CR (BCR) exhibits synergistically enhanced anti-anxiety performance.

Article Title: Protective effect of apiaceous vegetables against Total Western Diet- and dextran sulfate sodium-induced colitis in mice.
Article Snippet: .. The data matrix was then exported into 235 SIMCA-P+TM software (Umetrics, Kinnelon, NJ) and transformed by Pareto scaling. ..

Article Title: Decoding Volatile Organic Compounds' Signatures of 14 Trichoderma Isolates to Predict Antifungal Activity against Rice Pathogens through Integrated Chemical, Multivariate, and Computational Analyses.
Article Snippet: Volatile organic compounds (VOCs) produced by Trichoderma spp. play a pivotal role in the biocontrol of phytopathogens.. In this study, VOC profiles were characterized from 14 isolates representing eight Trichoderma species, and their antifungal activity was evaluated against Sclerotium oryzae and Rhizoctonia solani.. The isolates CRRI-T5 (T. atroviride) and NRRIT27 (T. reesei) were found to be the most potent isolates.

Article Title: Deciphering the mechanism of EGCG in improving ovarian function of late-laying hens: Insights from transcriptomic and metabolomic analyses.
Article Snippet: This study aimed to systematically investigate the comprehensive effects of dietary supplementation epigallocatechin-3-gallate (EGCG) on laying performance and health in late-laying hens, with a focus on its mechanisms.. This study investigated the comprehensive effects of dietary 300 mg/kg EGCG on 58-week-old late-laying Dawu Jinfeng hens (n = 180) over 21 days, using a multi-omics approach.. The results showed that EGCG significantly improved laying rate, egg quality (eggshell thickness/strength, yolk color, and Haugh unit), and egg amino acid content (serine, methionine, lysine, and proline).

Article Title: Integrated metabolomics of tumor and plasma reveals local and systemic metabolic responses to T-DM1 therapy.
Article Snippet: Comprehensive mapping of drug-induced metabolic alterations is crucial for understanding the mechanisms of targeted therapies.. Antibody–drug conjugates (ADCs) such as trastuzumab emtansine (T-DM1) have revolutionized targeted cancer therapy by combining antibody specificity with cytotoxic potency.. However, the metabolic reprogramming underlying their therapeutic action and systemic effects remains poorly understood.

Article Title: Integration of metabolomics and proteomics reveals the toxicological mechanisms of environmentally relevant concentrations of cadmium on juvenile rockfish (Sebastes schlegelii).
Article Snippet: As a highly toxic heavy metal, cadmium (Cd) is widely distributed in the coastal environments of the Bohai Sea, posing significant ecological and health risks.. This is of particular concern for Sebastes schlegelii, a rockfish species commonly found along the Bohai coast and consumed by local populations.. In this study, juvenile S. schlegelii were randomly assigned to three groups (control, 5 and 50 μg/L Cd) for a 14-day exposure period, followed by analysis of Cd bioaccumulation, as well as metabolomic and proteomic profiling.

Article Title: Assessment of synergistic effects of ultrasonication, ozonation and their combination with aloe vera active edible coating containing spirulina and turmeric extracts on preservation of fresh-cut apples.
Article Snippet: .. Principal component analysis (PCA) was carried out using SIMCA software (version 14.1; MKS Umetrics AB) to explore multivariate variations among FCA treatments (NT, CT, UC, OC, and UOC) over the storage period (0, 7, 14, 21, 28, 35, and 42 days). ..

Transformation Assay:

Article Title: Protective effect of apiaceous vegetables against Total Western Diet- and dextran sulfate sodium-induced colitis in mice.
Article Snippet: .. The data matrix was then exported into 235 SIMCA-P+TM software (Umetrics, Kinnelon, NJ) and transformed by Pareto scaling. ..

Generated:

Article Title: Deciphering the mechanism of EGCG in improving ovarian function of late-laying hens: Insights from transcriptomic and metabolomic analyses.
Article Snippet: This study aimed to systematically investigate the comprehensive effects of dietary supplementation epigallocatechin-3-gallate (EGCG) on laying performance and health in late-laying hens, with a focus on its mechanisms.. This study investigated the comprehensive effects of dietary 300 mg/kg EGCG on 58-week-old late-laying Dawu Jinfeng hens (n = 180) over 21 days, using a multi-omics approach.. The results showed that EGCG significantly improved laying rate, egg quality (eggshell thickness/strength, yolk color, and Haugh unit), and egg amino acid content (serine, methionine, lysine, and proline).

Chromatography:

Article Title: Deciphering the mechanism of EGCG in improving ovarian function of late-laying hens: Insights from transcriptomic and metabolomic analyses.
Article Snippet: This study aimed to systematically investigate the comprehensive effects of dietary supplementation epigallocatechin-3-gallate (EGCG) on laying performance and health in late-laying hens, with a focus on its mechanisms.. This study investigated the comprehensive effects of dietary 300 mg/kg EGCG on 58-week-old late-laying Dawu Jinfeng hens (n = 180) over 21 days, using a multi-omics approach.. The results showed that EGCG significantly improved laying rate, egg quality (eggshell thickness/strength, yolk color, and Haugh unit), and egg amino acid content (serine, methionine, lysine, and proline).

Mass Spectrometry:

Article Title: Deciphering the mechanism of EGCG in improving ovarian function of late-laying hens: Insights from transcriptomic and metabolomic analyses.
Article Snippet: This study aimed to systematically investigate the comprehensive effects of dietary supplementation epigallocatechin-3-gallate (EGCG) on laying performance and health in late-laying hens, with a focus on its mechanisms.. This study investigated the comprehensive effects of dietary 300 mg/kg EGCG on 58-week-old late-laying Dawu Jinfeng hens (n = 180) over 21 days, using a multi-omics approach.. The results showed that EGCG significantly improved laying rate, egg quality (eggshell thickness/strength, yolk color, and Haugh unit), and egg amino acid content (serine, methionine, lysine, and proline).

other:

Article Title: Characterization of saponin biotransformation driven by intrinsic proteins in Aralia elata leaves
Article Snippet: Raw data from untargeted metabolomic analysis were processed using Progenesis QI (Waters, USA) for peak alignment and normalization.



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Image Search Results


The procedures for within-target validation (left side) and cross-pathway validation (right side) of the platform PBPK-QSP model originally developed for T-DM1. AD: Aggregate data; IPD: Individual patient data; mAb: monoclonal antibody; NHP: Non-human primates; PD: pharmacodynamics; PFS: progression-free survival; PK: pharmacokinetics; SAR408701: Tusamitamab ravtansine; (T-)Dxd: trastuzumab deruxtran;; : In vitro cell culture experiment; : In vivo mouse experiment; : In vivo NHP experiment; : Clinical trial data.

Journal: medRxiv

Article Title: Translational PBPK-QSP modeling platform for antibody-drug conjugates (ADC): within-target and cross-pathway validation to bridge preclinical and clinical results

doi: 10.64898/2026.01.30.26345218

Figure Lengend Snippet: The procedures for within-target validation (left side) and cross-pathway validation (right side) of the platform PBPK-QSP model originally developed for T-DM1. AD: Aggregate data; IPD: Individual patient data; mAb: monoclonal antibody; NHP: Non-human primates; PD: pharmacodynamics; PFS: progression-free survival; PK: pharmacokinetics; SAR408701: Tusamitamab ravtansine; (T-)Dxd: trastuzumab deruxtran;; : In vitro cell culture experiment; : In vivo mouse experiment; : In vivo NHP experiment; : Clinical trial data.

Article Snippet: For cross-pathway validation with SAR408701 (tusamitamab ravtansine), we thankfully acknowledge the provision of data from the ADC development at Sanofi, which are not publicly available, though.

Techniques: Biomarker Discovery, Drug discovery, In Vitro, Cell Culture, In Vivo