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computer‐generated randomization scheme  (Teva)

 
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    Structured Review

    Teva computer‐generated randomization scheme
    Computer‐Generated Randomization Scheme, supplied by Teva, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/computer-generated+randomization+scheme/randomisation+scheme/pmc10765473-1492-11-17
    Average 90 stars, based on 1 article reviews
    computer‐generated randomization scheme - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Sequencing:

    Article Title: Treatment with disease-modifying drugs for people with a first clinical attack suggestive of multiple sclerosis
    Article Snippet: .. Teva retains the right to delete confidential information and to object to suggest publication and/or its timing (at the Company’s sole discretion) If Teva chooses to publish this study a copy will be provided to the investigator at least 30 days prior to the expected date of submission to the intended publisher (trial.gov) Risk of bias Risk of bias Bias Authors’ judgement Support for judgement Random sequence generation (selection bias) Low risk “The randomisation scheme was produced by the sponsor of the study with a 1:1 assignment ratio. .. A SAS-based blocks with block size of 4, stratified by centre was used”. (p 1504) Allocation concealment (selection bias) Unclear risk No information Other major baseline imbalance Low risk The study appears to be free of sources of bias related to major baseline imbalance. (table 2; p 1506) Blinding of participants and personnel (performance bias) All outcomes High risk The criterion to enter the prospectively planned open label study phase was either a second relapse or the end of the double-blind phase, whichever came first.

    Article Title: Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis
    Article Snippet: .. Random sequence generation (selection bias) , Low risk , " The computer‐generated randomization scheme prepared by the Teva Global Biostatistics Unit " (Page 775). .. Allocation concealment (selection bias) , Unclear risk , " 1:1:1 treatment assignment ratio stratified by study center, to laquinimod 0.6 mg capsule once‐daily, matching oral placebo, or IFNß‐1a IM 30 μg once‐weekly injection " (Page 775).

    Article Title: GLACIER: An open-label, randomized, multicenter study to assess the safety and tolerability of glatiramer acetate 40 mg three-times weekly versus 20 mg daily in patients with relapsing-remitting multiple sclerosis.
    Article Snippet: .. The computerized randomization sequence was generated and maintained by the Clinical Supply Chain department at Teva Pharmaceuticals (Netanya, Israel), and randomization was conducted centrally using the Interactive Response Technology system. ..

    Article Title: Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis
    Article Snippet: .. Random sequence generation (selection bias) , Low risk , " The computer‐generated randomization scheme prepared by the Teva Global Biostatistics Unit " (page 775). .. Allocation concealment (selection bias) , Unclear risk , " 1:1:1 treatment assignment ratio stratified by study center, to laquinimod 0.6 mg capsule once‐daily, matching oral placebo, or IFNß‐1a IM 30 μg once‐weekly injection " (page 775).

    Selection:

    Article Title: Treatment with disease-modifying drugs for people with a first clinical attack suggestive of multiple sclerosis
    Article Snippet: .. Teva retains the right to delete confidential information and to object to suggest publication and/or its timing (at the Company’s sole discretion) If Teva chooses to publish this study a copy will be provided to the investigator at least 30 days prior to the expected date of submission to the intended publisher (trial.gov) Risk of bias Risk of bias Bias Authors’ judgement Support for judgement Random sequence generation (selection bias) Low risk “The randomisation scheme was produced by the sponsor of the study with a 1:1 assignment ratio. .. A SAS-based blocks with block size of 4, stratified by centre was used”. (p 1504) Allocation concealment (selection bias) Unclear risk No information Other major baseline imbalance Low risk The study appears to be free of sources of bias related to major baseline imbalance. (table 2; p 1506) Blinding of participants and personnel (performance bias) All outcomes High risk The criterion to enter the prospectively planned open label study phase was either a second relapse or the end of the double-blind phase, whichever came first.

    Article Title: Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis
    Article Snippet: .. Random sequence generation (selection bias) , Low risk , " The computer‐generated randomization scheme prepared by the Teva Global Biostatistics Unit " (Page 775). .. Allocation concealment (selection bias) , Unclear risk , " 1:1:1 treatment assignment ratio stratified by study center, to laquinimod 0.6 mg capsule once‐daily, matching oral placebo, or IFNß‐1a IM 30 μg once‐weekly injection " (Page 775).

    Article Title: Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis
    Article Snippet: .. Random sequence generation (selection bias) , Low risk , " The computer‐generated randomization scheme prepared by the Teva Global Biostatistics Unit " (page 775). .. Allocation concealment (selection bias) , Unclear risk , " 1:1:1 treatment assignment ratio stratified by study center, to laquinimod 0.6 mg capsule once‐daily, matching oral placebo, or IFNß‐1a IM 30 μg once‐weekly injection " (page 775).

    Produced:

    Article Title: Treatment with disease-modifying drugs for people with a first clinical attack suggestive of multiple sclerosis
    Article Snippet: .. Teva retains the right to delete confidential information and to object to suggest publication and/or its timing (at the Company’s sole discretion) If Teva chooses to publish this study a copy will be provided to the investigator at least 30 days prior to the expected date of submission to the intended publisher (trial.gov) Risk of bias Risk of bias Bias Authors’ judgement Support for judgement Random sequence generation (selection bias) Low risk “The randomisation scheme was produced by the sponsor of the study with a 1:1 assignment ratio. .. A SAS-based blocks with block size of 4, stratified by centre was used”. (p 1504) Allocation concealment (selection bias) Unclear risk No information Other major baseline imbalance Low risk The study appears to be free of sources of bias related to major baseline imbalance. (table 2; p 1506) Blinding of participants and personnel (performance bias) All outcomes High risk The criterion to enter the prospectively planned open label study phase was either a second relapse or the end of the double-blind phase, whichever came first.

    Article Title: Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial
    Article Snippet: Methods In this randomised, double-blind trial, undertaken in 80 sites in 16 countries, 481 patients presenting with a clinically isolated syndrome with unifocal manifestation, and two or more T2-weighted brain lesions measuring 6 mm or more, were randomly assigned to receive either subcutaneous glatiramer acetate 20 mg per day (n=243) or placebo (n=238) for up to 36 months, unless they converted to clinically defi nite multiple sclerosis.. The randomisation scheme used SAS-based blocks stratifi ed by centre, and patients and all personnel were masked to treatment assignment.. The primary endpoint was time to clinically defi nite multiple sclerosis, based on a second clinical attack.

    other:

    Article Title: Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis
    Article Snippet: Bias Authors’ judgement Support for judgement Random sequence generation (selection bias) Low risk “The computer-generated randomization scheme prepared by the Teva Global Biostatistics Unit” (Page 775) Allocation concealment (selection bias) Unclear risk “1:1:1 treatment assignment ratio stratified by study center, to laquinimod 0.6 mg capsule once-daily, matching oral placebo, or IFNß-1a IM 30 μg once-weekly injection” (Page 775) Blinding of participants and personnel (performance bias) All outcomes High risk “Patients and treating neurologists were blinded to oral treatment assignment (laquinimod or placebo), but not to IFNb-1a IM assignment”, and “All patients, including those receiving oral treatment, wore clothing and/or a robe that ensured coverage of all potential 70Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis (Review) Copyright © 2015 The Cochrane Collaboration.

    Generated:

    Article Title: GLACIER: An open-label, randomized, multicenter study to assess the safety and tolerability of glatiramer acetate 40 mg three-times weekly versus 20 mg daily in patients with relapsing-remitting multiple sclerosis.
    Article Snippet: .. The computerized randomization sequence was generated and maintained by the Clinical Supply Chain department at Teva Pharmaceuticals (Netanya, Israel), and randomization was conducted centrally using the Interactive Response Technology system. ..



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