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Protox Therapeutics protox ii computational tool
Protox Ii Computational Tool, supplied by Protox Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computational+tool/analysis+iii+protox/pm41136693-40-7-7
Average 86 stars, based on 1 article reviews
protox ii computational tool - by Bioz Stars, 2026-09
86/100 stars

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Article Title: Determination of the In Vitro Cytotoxic Activities of Several Coumarin Derivatives on Neuroblastoma Cell Lines With In Silico Inhibitory Effects on CDK9, VEGFR2 and EGFR Proteins and ADME Studies.
Article Snippet: Due to their stable nature and medical applicability properties, coumarin derivatives have fascinated medicinal chemists in the discovery of novel therapeutics.. In this study, the cytotoxic/anticancer properties of some newly synthesized coumarin derivatives were aimed at designing, synthesizing, and examining cultured human neuroblastoma cells.. Moreover, molecular docking studies were carried out to determine the potential mechanism.

Article Title: Machine learning-guided identification and simulation-based validation of potent JAK3 inhibitors for cancer therapy
Article Snippet: Toxicity predictions from the ProTox-II analysis revealed that all three compounds exhibited low acute toxicity, with LD50 values ranging from 1300 to 2000 mg/kg, placing them within toxicity class IV.

Article Title: Investigating the ameliorative effect of Kalanchoe pinnata on neuroinflammation-associated Alzheimer's disease using network pharmacology, molecular docking, and in vitro studies.
Article Snippet: CC Cellular component MF Molecular function KEGG Kyoto encyclopedia of genes and genomes AKT1 AKT serine/threonine kinase 1 SRC Tyrosine-protein kinase SRC TNF-α Tumor necrosis factor-alpha ALB Albumin STAT3 Signal transducer and activator of transcription 3 EGFR Epidermal growth factor receptor BCL2 B-cell lymphoma/leukemia 2 ESR1 Estrogen receptor 1 HSP90AA1 Heat shock protein 90 alpha family class A member 1 JUN Jun proto-oncogene, AP-1 transcription factor subunit cAMP Cyclic adenosine monophosphate MAPK Mitogen-activated protein kinase PI3K Phosphatidylinositol 3-kinase Abbreviations AD Alzheimer’s disease KPAE Kalanchoe pinnata aqueous extract ABTS 2,2′-Azino-bis(3-ethylbenzothiazoline6-sulfonic acid) IMPPAT 2.0 Indian medicinal plants, phytochemistry and therapeutics 2.0 DPPH 2Diphenyl-1-picrylhydrazyl GO Gene ontology BP Biological process

Article Title: Identification of Novel Mutant (R132H) Isocitrate Dehydrogenase 1 Inhibitors for Glioma Therapy
Article Snippet: The potential acute toxicity endpoints associated with the chemical structure of screened lead molecules were assessed using the Protox-II algorithm.

Article Title: Integrative structure-based approach for phytocompound-based dual therapeutics targeting Alzheimer's and Parkinson's disease.
Article Snippet: Neurodegenerative diseases like Alzheimer's and Parkinson's are growing global health concerns with limited treatment options.. In this study, we explored four natural compounds—Baicalein, Vincarubine, Rutin, and Luteolin—for their potential as multi-target drugs using computational methods.. These compounds were tested against key proteins involved in disease progression, including LRRK2, APP, and Tau kinase.

Article Title: Target identification and mechanism elucidation of Chai Hu Shu Gan-San against the comorbidity of insomnia and depression based on integrative computational pharmacology
Article Snippet: Medicine (TCM), has been used for a long time for mood and sleep disturbances.. Recent clinical and experimental findings support its therapeutic benefits, which are attributed to its multi-component and multi-target pharmacology (Zhu et al. 2022; Zeng et al. 2023).. Our analysis suggests that CHSGS functions through serotonergic synapse modulation, neuroactive ligand-receptor interactions, and inflammatory signaling pathways.

Synthesized:

Article Title: Structural analysis of ITS 1 gene of Leishmania tropica and evaluation of a novel ligand, benzo[d][1,3]dioxol-5-yl 4-acetamidobenzenesulfonate, via molecular modeling methods
Article Snippet: .. In addition, based on the broad pharmacological properties of sesamol and sulfonate esters, as well as the results obtained from ProTox-III analysis, compound 3 was synthesized and its effect on L. tropica was investigated. ..



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