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pantoprazole sulfone  (Toronto Research Chemicals)


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    Structured Review

    Toronto Research Chemicals pantoprazole sulfone
    Mean plasma <t>pantoprazole</t> concentration (logarithmic scale) vs. time (hr) profiles for neonatal calves ( n = 9) following intravenous (IV) single dose administration of 1.0 mg/kg of pantoprazole.
    Pantoprazole Sulfone, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound/Pantoprazole+Sulfone/pmc07728716-141-0-2
    Average 93 stars, based on 5 article reviews
    pantoprazole sulfone - by Bioz Stars, 2026-11
    93/100 stars

    Images

    1) Product Images from "Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration"

    Article Title: Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration

    Journal: Frontiers in Veterinary Science

    doi: 10.3389/fvets.2020.580735

    Mean plasma pantoprazole concentration (logarithmic scale) vs. time (hr) profiles for neonatal calves ( n = 9) following intravenous (IV) single dose administration of 1.0 mg/kg of pantoprazole.
    Figure Legend Snippet: Mean plasma pantoprazole concentration (logarithmic scale) vs. time (hr) profiles for neonatal calves ( n = 9) following intravenous (IV) single dose administration of 1.0 mg/kg of pantoprazole.

    Techniques Used: Clinical Proteomics, Concentration Assay

     Pantoprazole  pharmacokinetic parameters following a single intravenous (1 mg/kg) administration to neonatal Holstein calves.
    Figure Legend Snippet: Pantoprazole pharmacokinetic parameters following a single intravenous (1 mg/kg) administration to neonatal Holstein calves.

    Techniques Used:

    Tissue concentrations of  pantoprazole sulfone  (μg/g) in collected tissues 1, 3, and 5 days after intravenous administration of pantoprazole (1 mg/kg) from study calves.
    Figure Legend Snippet: Tissue concentrations of pantoprazole sulfone (μg/g) in collected tissues 1, 3, and 5 days after intravenous administration of pantoprazole (1 mg/kg) from study calves.

    Techniques Used:

    Comparisons of pharmacokinetic parameters of  pantoprazole  in domestic animal species, after single dose intravenous administration.
    Figure Legend Snippet: Comparisons of pharmacokinetic parameters of pantoprazole in domestic animal species, after single dose intravenous administration.

    Techniques Used:

    Related Articles

    Clinical Proteomics:

    Article Title: Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration
    Article Snippet: Therefore, all the tissue samples were re-extracted as outlined previously in our methods.Therefore, all the tissue samples were re-extracted as outlined previously in our methods.. Pantoprazole sulfone (Toronto Research Chemicals, Ontario, Canada) became the analyte spiked into blank tissue samples to generate calibration spikes and QC samples.. Parallel reaction monitoring in the positive electrospray ion mode was used for analyte detection.Parallel reaction monitoring in the positive electrospray ion mode was used for analyte detection.

    Article Title: Stability of pantoprazole sodium in glass vials, polyvinyl chloride minibags, and polypropylene syringes.
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N-oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N-oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N-oxide (catalogue no. P183013, lot 11-AZC-60-1).

    Article Title: Stability of Pantoprazole Sodium in Glass Vials, Polyvinyl Chloride Minibags, and Polypropylene Syringes
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N -oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N -oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N -oxide (catalogue no. P183013, lot 11-AZC-60-1).

    Article Title: Stability of Pantoprazole Sodium in Glass Vials, Polyvinyl Chloride Minibags, and Polypropylene Syringes
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N -oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N -oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N -oxide (catalogue no. P183013, lot 11-AZC-60-1).. Stability Study A single 5-mL sample was collected from each container (as described in the “Sample Preparation” section above) immediately after packaging and was placed into a clean glass test tube.Stability Study A single 5-mL sample was collected from each container (as described in the “Sample Preparation” section above) immediately after packaging and was placed into a clean glass..

    Concentration Assay:

    Article Title: Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration
    Article Snippet: Therefore, all the tissue samples were re-extracted as outlined previously in our methods.Therefore, all the tissue samples were re-extracted as outlined previously in our methods.. Pantoprazole sulfone (Toronto Research Chemicals, Ontario, Canada) became the analyte spiked into blank tissue samples to generate calibration spikes and QC samples.. Parallel reaction monitoring in the positive electrospray ion mode was used for analyte detection.Parallel reaction monitoring in the positive electrospray ion mode was used for analyte detection.

    Article Title: Stability of pantoprazole sodium in glass vials, polyvinyl chloride minibags, and polypropylene syringes.
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N-oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N-oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N-oxide (catalogue no. P183013, lot 11-AZC-60-1).

    Article Title: Stability of Pantoprazole Sodium in Glass Vials, Polyvinyl Chloride Minibags, and Polypropylene Syringes
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N -oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N -oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N -oxide (catalogue no. P183013, lot 11-AZC-60-1).

    Article Title: Stability of Pantoprazole Sodium in Glass Vials, Polyvinyl Chloride Minibags, and Polypropylene Syringes
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N -oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N -oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N -oxide (catalogue no. P183013, lot 11-AZC-60-1).. Stability Study A single 5-mL sample was collected from each container (as described in the “Sample Preparation” section above) immediately after packaging and was placed into a clean glass test tube.Stability Study A single 5-mL sample was collected from each container (as described in the “Sample Preparation” section above) immediately after packaging and was placed into a clean glass..

    High Performance Liquid Chromatography:

    Article Title: Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration
    Article Snippet: Therefore, all the tissue samples were re-extracted as outlined previously in our methods.Therefore, all the tissue samples were re-extracted as outlined previously in our methods.. Pantoprazole sulfone (Toronto Research Chemicals, Ontario, Canada) became the analyte spiked into blank tissue samples to generate calibration spikes and QC samples.. Parallel reaction monitoring in the positive electrospray ion mode was used for analyte detection.Parallel reaction monitoring in the positive electrospray ion mode was used for analyte detection.

    Article Title: Stability of pantoprazole sodium in glass vials, polyvinyl chloride minibags, and polypropylene syringes.
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N-oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N-oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N-oxide (catalogue no. P183013, lot 11-AZC-60-1).

    Article Title: Stability of Pantoprazole Sodium in Glass Vials, Polyvinyl Chloride Minibags, and Polypropylene Syringes
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N -oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N -oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N -oxide (catalogue no. P183013, lot 11-AZC-60-1).

    Article Title: Stability of Pantoprazole Sodium in Glass Vials, Polyvinyl Chloride Minibags, and Polypropylene Syringes
    Article Snippet: The sensitivity of the assay was also determined.The sensitivity of the assay was also determined.. Five known degradation or impurity products of pantoprazole sodium (all obtained from Toronto Research Chemicals Inc) were analyzed for potential interference with the parent compound: pantoprazole N -oxide (catalogue no. P183010, lot 11-AZC-121-1), pantoprazole sulphide (catalogue no. P183020, lot 11-SWM-22-1), pantoprazole sulphide N -oxide (catalogue no. P183030, lot 11-AZC-115-1), pantoprazole sulphone (catalogue no. P183015, lot 11-AZC-47-1), and pantoprazole sulphone N -oxide (catalogue no. P183013, lot 11-AZC-60-1).. Stability Study A single 5-mL sample was collected from each container (as described in the “Sample Preparation” section above) immediately after packaging and was placed into a clean glass test tube.Stability Study A single 5-mL sample was collected from each container (as described in the “Sample Preparation” section above) immediately after packaging and was placed into a clean glass..



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    Image Search Results


    Reaction schemes and LC-MS analysis of Pp UGTs reactions with diosgenin and pennogenin . ( a ) Biosynthesis of trillin mediated by UGT91BP2 and UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of diosgenin. ( b ) Extracted ion chromatograms (EICs) of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and diosgenin showing the formation of trillin, as compared to the authentic trillin standard. Control is the empty expression vector. ( c ) MS spectra of the enzymatic reaction products in hydrogen and sodium ion adducts compared to the fragmentation pattern of the trillin standard. The product molecular ions [M + H] + and [M +Na] + and the feature fragment ion [M + H − Glc] + with m / z 415.32 are marked. Of note, additional peaks observed in the diosgenin EIC ( m / z 415.32) for UGT703R1–3 might correspond to substrate isomeric impurities, in-source adducts, or minor non-enzymatic by-products; these peaks, which arose from the extracted ion flow of the substrate m / z , did not co-elute with the product, trillin , and therefore did not affect the interpretation of the product formation. ( d ) Biosynthesis of pennogenin 3- O -glucoside mediated by the UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of pennogenin. ( e ) EICs of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and pennogenin showing the formation of pennogenin 3- O -glucoside, compared to the control empty expression vector. ( f ) MS/MS spectra ([M + H – Glc] + and [M + H – Glc − H 2 O] + ) of the enzymatic reaction products.

    Journal: Synthetic and Systems Biotechnology

    Article Title: Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant Paris polyphylla

    doi: 10.1016/j.synbio.2026.04.002

    Figure Lengend Snippet: Reaction schemes and LC-MS analysis of Pp UGTs reactions with diosgenin and pennogenin . ( a ) Biosynthesis of trillin mediated by UGT91BP2 and UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of diosgenin. ( b ) Extracted ion chromatograms (EICs) of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and diosgenin showing the formation of trillin, as compared to the authentic trillin standard. Control is the empty expression vector. ( c ) MS spectra of the enzymatic reaction products in hydrogen and sodium ion adducts compared to the fragmentation pattern of the trillin standard. The product molecular ions [M + H] + and [M +Na] + and the feature fragment ion [M + H − Glc] + with m / z 415.32 are marked. Of note, additional peaks observed in the diosgenin EIC ( m / z 415.32) for UGT703R1–3 might correspond to substrate isomeric impurities, in-source adducts, or minor non-enzymatic by-products; these peaks, which arose from the extracted ion flow of the substrate m / z , did not co-elute with the product, trillin , and therefore did not affect the interpretation of the product formation. ( d ) Biosynthesis of pennogenin 3- O -glucoside mediated by the UGT703R1–3 through transferring glucose from UDP-glucose to the C-3 OH position of pennogenin. ( e ) EICs of the in vitro enzyme activity assays of recombinant UGT91BP2 and UGT703R1–3 with UDP-glucose and pennogenin showing the formation of pennogenin 3- O -glucoside, compared to the control empty expression vector. ( f ) MS/MS spectra ([M + H – Glc] + and [M + H – Glc − H 2 O] + ) of the enzymatic reaction products.

    Article Snippet: Diosgenin, pennogenin, and trillin standard compounds were purchased from Chengdu Push Biotechnology Co., Ltd., and Shanghai Yuanye Biotechnology Co., Ltd. (China).

    Techniques: Liquid Chromatography with Mass Spectroscopy, Transferring, In Vitro, Activity Assay, Recombinant, Control, Expressing, Plasmid Preparation, Tandem Mass Spectroscopy

    Transient expression and characterization of Pp UGTs in Nicotiana benthamiana . ( a ) UHPLC-MS traces of the trillin formation in N. benthamiana leaf extracts transiently expressing UGT91BP2 and UGT703R1–3 with the infiltration of diosgenin substrate, compared to trillin authentic standard and empty vector control. Q1: parent ion; Q3: daughter ion. ( b ) Confocal microscopic images of the localization of UGT91BP2-GFP, UGT703R1-GFP, UGT703R2-GFP and UGT703R3-GFP in N. benthamiana leaves. DAPI (a nuclear-specific fluorescence dye) acts as a nucleus indicator. Scale bars, 20 μm. The experiments were repeated two times with similar results.

    Journal: Synthetic and Systems Biotechnology

    Article Title: Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant Paris polyphylla

    doi: 10.1016/j.synbio.2026.04.002

    Figure Lengend Snippet: Transient expression and characterization of Pp UGTs in Nicotiana benthamiana . ( a ) UHPLC-MS traces of the trillin formation in N. benthamiana leaf extracts transiently expressing UGT91BP2 and UGT703R1–3 with the infiltration of diosgenin substrate, compared to trillin authentic standard and empty vector control. Q1: parent ion; Q3: daughter ion. ( b ) Confocal microscopic images of the localization of UGT91BP2-GFP, UGT703R1-GFP, UGT703R2-GFP and UGT703R3-GFP in N. benthamiana leaves. DAPI (a nuclear-specific fluorescence dye) acts as a nucleus indicator. Scale bars, 20 μm. The experiments were repeated two times with similar results.

    Article Snippet: Diosgenin, pennogenin, and trillin standard compounds were purchased from Chengdu Push Biotechnology Co., Ltd., and Shanghai Yuanye Biotechnology Co., Ltd. (China).

    Techniques: Expressing, Plasmid Preparation, Control, Fluorescence

    Journal: eLife

    Article Title: Multiplexed CRISPRi reveals a transcriptional switch between KLF activators and repressors in the maturing neocortex

    doi: 10.7554/eLife.106510

    Figure Lengend Snippet:

    Article Snippet: Chemical compound , Opal 620 , Akoya Biosciences , FP1495001KT , 1:750 –1:1500.

    Techniques: