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orion platform  (OpenEye Scientific Software Inc)

 
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    OpenEye Scientific Software Inc orion platform
    Orion Platform, supplied by OpenEye Scientific Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cloud+software/orion+cloud+computing+platform/pmc07228781-666-13-12
    Average 90 stars, based on 1 article reviews
    orion platform - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Interactive Quantum Chemistry Enabled by Machine Learning, Graphical Processing Units, and Cloud Computing.
    Article Snippet: This latter strategy has been adopted by projects such as TeraChem Cloud (63) and OpenEye’s Orion platform (64).

    Article Title: Mechanistic Insights into Passive Membrane Permeability of Drug-like Molecules from a Weighted Ensemble of Trajectories
    Article Snippet: Scientific computing in OpenEye’s Orion cloud platform is patterned after the concept of flow-based programming (FBP).

    Article Title: Impact of protein conformations on binding free energy calculations in the beta-secretase 1 system.
    Article Snippet: Funding information Pfizer; National Institute of General Medical Sciences, Grant/Award Numbers: R01GM108889, R35GM148236 Abstract In binding free energy calculations, simulations must sample all relevant conformations of the system in order to obtain unbiased results.. For instance, different ligands can bind to different metastable states of a protein, and if these protein conformational changes are not sampled in relative binding free energy calculations, the contribution of these states to binding is not accounted for and thus calculated binding free energies are inaccurate.. In this work, we investigate the impact of different beta-sectretase 1 (BACE1) protein conformations obtained from x-ray crystallography on the binding of BACE1 inhibitors.

    Article Title: A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins
    Article Snippet: Lastly, a 3D shape-based ROCS hit expansion search (Openeye ORION platform) of the 4 original hits was conducted and a set of compounds with good shape complementarity (Tanimoto combo score > 1.4) to the original hits was ordered and assayed.

    Article Title: Insights into next generation sequencing guided antibody selection strategies
    Article Snippet: The workflows were built on the Orion® platform (eyesopen.com/orion) in collaboration with OpenEye, Cadence Molecular Sciences.

    Article Title: Early Career Perspectives from Large Pharma, Software, and Start-up Companies
    Article Snippet: In recent years, OpenEye has expanded significantly with the introduction of Orion, a cloud computing platform for drug design.

    Article Title: WESTPA 2.0: High-Performance Upgrades for Weighted Ensemble Simulations and Analysis of Longer-Timescale Applications
    Article Snippet: WESTPA has also been interfaced with OpenEye Scientific’s Orion platform 39 on the Amazon Web Services cloud computing facility.

    Article Title: Broadening the Scope of Binding Free Energy Calculations Using a Separated Topologies Approach
    Article Snippet: We performed the structure preparation on OpenEye’s Orion cloud computing platform, using their workflow (”floe”) “SPRUCE-Protein Preparation from PDB Codes” with the default parameters.



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    Image Search Results


    Proliferation of T cells from patients ( N = 6), TC ( N = 8), and local controls (LC; N = 6), assessed by CFSE dilution after 5 days of anti-CD3/CD28 stimulation. ( B ) Cytokine production by memory T cells from patients ( N = 6), TC ( N = 8), and LC ( N = 6) after 24-hour anti-CD3/CD28 stimulation, assessed by flow cytometry. ( C ) Cytokine production by CLA + (skin-tropic) and CLA − memory CD4 T cells from patients ( N = 6) and controls ( N = 14). Cytokines secreted by PBMCs from patients ( N = 6), TC ( N = 6), and LC ( N = 6) after 24-hour anti-CD3/CD28 stimulation, measured by LEGENDplex. Proliferation of αL-deficient T cells (from patients) cocultured with allogeneic MDDCs at the indicated ratios. Representative CFSE histograms are shown on the right (DC:T 1:2). Each dot represents one allogeneic pairing (LC, N = 10; TC, N = 8; P, N = 6). See also ( to ). Proliferation of allogeneic T cells (from controls, N = 7) induced by MDDCs from P1 or healthy donors (HDs). Representative CFSE histograms are shown on the right (DC:T 1:2). Each dot represents one allogeneic pairing. See also ( and ). Two-way ANOVA tests with Tukey’s correction were used in (A), (B), (D), and (E). Mann-Whitney tests with Holm-Šidák correction were used in (C) and (F). * P < 0.05 and ** P < 0.01. MHC, major histocompatibility complex.

    Journal: Science immunology

    Article Title: Human LFA-1 governs T cell immune surveillance of the skin

    doi: 10.1126/sciimmunol.adz8360

    Figure Lengend Snippet: Proliferation of T cells from patients ( N = 6), TC ( N = 8), and local controls (LC; N = 6), assessed by CFSE dilution after 5 days of anti-CD3/CD28 stimulation. ( B ) Cytokine production by memory T cells from patients ( N = 6), TC ( N = 8), and LC ( N = 6) after 24-hour anti-CD3/CD28 stimulation, assessed by flow cytometry. ( C ) Cytokine production by CLA + (skin-tropic) and CLA − memory CD4 T cells from patients ( N = 6) and controls ( N = 14). Cytokines secreted by PBMCs from patients ( N = 6), TC ( N = 6), and LC ( N = 6) after 24-hour anti-CD3/CD28 stimulation, measured by LEGENDplex. Proliferation of αL-deficient T cells (from patients) cocultured with allogeneic MDDCs at the indicated ratios. Representative CFSE histograms are shown on the right (DC:T 1:2). Each dot represents one allogeneic pairing (LC, N = 10; TC, N = 8; P, N = 6). See also ( to ). Proliferation of allogeneic T cells (from controls, N = 7) induced by MDDCs from P1 or healthy donors (HDs). Representative CFSE histograms are shown on the right (DC:T 1:2). Each dot represents one allogeneic pairing. See also ( and ). Two-way ANOVA tests with Tukey’s correction were used in (A), (B), (D), and (E). Mann-Whitney tests with Holm-Šidák correction were used in (C) and (F). * P < 0.05 and ** P < 0.01. MHC, major histocompatibility complex.

    Article Snippet: Data were analyzed with LEGENDplex Cloud-based Data Analysis Software (Qognit).

    Techniques: Flow Cytometry, MANN-WHITNEY, Immunopeptidomics