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Structured Review

Arraystar inc human circrnas microarray
Schematic illustration of the effect of circular RNAs <t>(circRNAs)</t> on intracranial aneurysm (IA) rupture. Current evidence strongly suggests a central role for endothelial dysfunction in the initiation and progression of IA. Post-subarachnoid hemorrhage (SAH), several early pathophysiological events can be commonly observed in blood-brain barrier (BBB) components, such as the endothelium (endothelial dysfunction). In results, post- SAH injuries can disrupt the integrity and function of the BBB . Both negative (red cross) and positive (green cross) regulation of circRNAs have been observed in this pathological cascade. The role of circRNAs is based on components: 1) strong role in endothelial cells (ECs) homeostasis; 2) regulation of barrier function and vascular tone; 3) associated with SAH and its complications; 4) correlates with clinical outcomes (Glasgow Coma Scale, the volume of SAH, modified Fisher scale, Hunt-Hess levels, and surgical type; 5) regulators of transcription/translation, sequesters of microRNA (miRNA)/RNA-binding proteins (RBPs), and biomarkers of IA.
Human Circrnas Microarray, supplied by Arraystar inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1) Product Images from "Circular RNAs in intracranial aneurysms: Emerging roles in pathogenesis, diagnosis and therapeutic intervention"

Article Title: Circular RNAs in intracranial aneurysms: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

Journal: Non-coding RNA Research

doi: 10.1016/j.ncrna.2023.11.012

Schematic illustration of the effect of circular RNAs (circRNAs) on intracranial aneurysm (IA) rupture. Current evidence strongly suggests a central role for endothelial dysfunction in the initiation and progression of IA. Post-subarachnoid hemorrhage (SAH), several early pathophysiological events can be commonly observed in blood-brain barrier (BBB) components, such as the endothelium (endothelial dysfunction). In results, post- SAH injuries can disrupt the integrity and function of the BBB . Both negative (red cross) and positive (green cross) regulation of circRNAs have been observed in this pathological cascade. The role of circRNAs is based on components: 1) strong role in endothelial cells (ECs) homeostasis; 2) regulation of barrier function and vascular tone; 3) associated with SAH and its complications; 4) correlates with clinical outcomes (Glasgow Coma Scale, the volume of SAH, modified Fisher scale, Hunt-Hess levels, and surgical type; 5) regulators of transcription/translation, sequesters of microRNA (miRNA)/RNA-binding proteins (RBPs), and biomarkers of IA.
Figure Legend Snippet: Schematic illustration of the effect of circular RNAs (circRNAs) on intracranial aneurysm (IA) rupture. Current evidence strongly suggests a central role for endothelial dysfunction in the initiation and progression of IA. Post-subarachnoid hemorrhage (SAH), several early pathophysiological events can be commonly observed in blood-brain barrier (BBB) components, such as the endothelium (endothelial dysfunction). In results, post- SAH injuries can disrupt the integrity and function of the BBB . Both negative (red cross) and positive (green cross) regulation of circRNAs have been observed in this pathological cascade. The role of circRNAs is based on components: 1) strong role in endothelial cells (ECs) homeostasis; 2) regulation of barrier function and vascular tone; 3) associated with SAH and its complications; 4) correlates with clinical outcomes (Glasgow Coma Scale, the volume of SAH, modified Fisher scale, Hunt-Hess levels, and surgical type; 5) regulators of transcription/translation, sequesters of microRNA (miRNA)/RNA-binding proteins (RBPs), and biomarkers of IA.

Techniques Used: Modification, RNA Binding Assay

Schematic illustration of circular RNAs (circRNAs) regulation mechanisms underlying vascular smooth muscle cells (VSMCs) phenotypic modulation, oxidative stress, and cell death in intracranial aneurysms (IAs). As can be seen from the figure, circRNAs play a role both in the development and progression of IA and in the inhibition of IA through the control of VSMC. However, some of them exhibit a double effect as circ_FOXO3 and circ_0020397.
Figure Legend Snippet: Schematic illustration of circular RNAs (circRNAs) regulation mechanisms underlying vascular smooth muscle cells (VSMCs) phenotypic modulation, oxidative stress, and cell death in intracranial aneurysms (IAs). As can be seen from the figure, circRNAs play a role both in the development and progression of IA and in the inhibition of IA through the control of VSMC. However, some of them exhibit a double effect as circ_FOXO3 and circ_0020397.

Techniques Used: Inhibition

Benefits of using cell free circular RNAs (circRNAs) as biomarkers.
Figure Legend Snippet: Benefits of using cell free circular RNAs (circRNAs) as biomarkers.

Techniques Used:

The studied cell free circular RNAs (circRNAs) are presented as non-invasive biomarkers in intracranial aneurysms (IAs).
Figure Legend Snippet: The studied cell free circular RNAs (circRNAs) are presented as non-invasive biomarkers in intracranial aneurysms (IAs).

Techniques Used:

Summary information on the role of circular RNAs  (circRNAs)  in the formation and development of intracranial aneurysms (IAs).
Figure Legend Snippet: Summary information on the role of circular RNAs (circRNAs) in the formation and development of intracranial aneurysms (IAs).

Techniques Used: Migration, Transformation Assay

Related Articles

Microarray:

Article Title: Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection
Article Snippet: .. The differentially expressed circRNAs profiles of the aortic segments between human type A TAD patients ( n =3) and age-matched normal donors (NA; n =3) were analyzed using the Arraystar human circRNAs microarray. ..

Article Title: Circular RNAs in intracranial aneurysms: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
Article Snippet: .. This analytical endeavor employs the Arraystar human circRNAs microarray to probe five samples of each tissue type, revealing a plethora of circRNAs that undergo significant upregulation or downregulation in IAs [ ]. ..

Article Title: Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.
Article Snippet: .. Here, we explore the panorama of circRNA expression in PBMCs purified from five newly diagnosed MS patients and five healthy controls (HCs) using the Arraystar Human circRNAs microarray. ..

Article Title: Circ ERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis
Article Snippet: .. Identification of differentially expressed circRNAs was performed by overlapping microarray analysis of human circRNAs (Arraystar, CA, USA) and microarray dataset (GSE67566) obtained from Gene Expression Omnibus (GEO) database. ..

Article Title: Circular RNAs in intracranial aneurysms: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
Article Snippet: .. Leveraging the power of the Arraystar human circRNAs microarray, differentially expressed circRNAs between patients with UIAs and RIAs were meticulously analyzed. ..

Article Title: Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia
Article Snippet: .. Chen et al. [ ] reported that circANAPC7 was significantly upregulated in AML and used an Arraystar human circRNAs microarray and bioinformatics analysis to predict when ANAPC7 might bind miR-181 family to participate in AML pathogenesis. ..

Article Title: The potential role of hsa_circ_0005505 in the rupture of human intracranial aneurysm
Article Snippet: .. Results The differentially expressed circular RNAs between un-ruptured intracranial aneurysms (n = 5) and ruptured intracranial aneurysms (n = 5) were analyzed with the Arraystar human circRNAs microarray and total of 13175 circular RNAs were detected. ..

Expressing:

Article Title: Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.
Article Snippet: .. Here, we explore the panorama of circRNA expression in PBMCs purified from five newly diagnosed MS patients and five healthy controls (HCs) using the Arraystar Human circRNAs microarray. ..

Purification:

Article Title: Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.
Article Snippet: .. Here, we explore the panorama of circRNA expression in PBMCs purified from five newly diagnosed MS patients and five healthy controls (HCs) using the Arraystar Human circRNAs microarray. ..

Gene Expression:

Article Title: Circ ERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis
Article Snippet: .. Identification of differentially expressed circRNAs was performed by overlapping microarray analysis of human circRNAs (Arraystar, CA, USA) and microarray dataset (GSE67566) obtained from Gene Expression Omnibus (GEO) database. ..

other:

Article Title: Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis.
Article Snippet: Microarray of circRNAs was performed in BGI.Tech (Beijing, China) and analyzed according to the Arraystar.



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Mechanisms of action of cirRNA: (A) CircRNAs have the capability to directly interact with transcription complexes, thereby influencing the expression of parental genes. (B) CircRNAs have the ability to act as miRNA sponges. (C) circRNAs can interact with <t>circRNA</t> binding proteins (cRBPs) modulate their functions. (D) CircRNAs have the ability to encode peptides and proteins.
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Image Search Results


Mechanisms of action of cirRNA: (A) CircRNAs have the capability to directly interact with transcription complexes, thereby influencing the expression of parental genes. (B) CircRNAs have the ability to act as miRNA sponges. (C) circRNAs can interact with circRNA binding proteins (cRBPs) modulate their functions. (D) CircRNAs have the ability to encode peptides and proteins.

Journal: Frontiers in Cellular and Infection Microbiology

Article Title: Recent progress in tuberculosis diagnosis: insights into blood-based biomarkers and emerging technologies

doi: 10.3389/fcimb.2025.1567592

Figure Lengend Snippet: Mechanisms of action of cirRNA: (A) CircRNAs have the capability to directly interact with transcription complexes, thereby influencing the expression of parental genes. (B) CircRNAs have the ability to act as miRNA sponges. (C) circRNAs can interact with circRNA binding proteins (cRBPs) modulate their functions. (D) CircRNAs have the ability to encode peptides and proteins.

Article Snippet: circRNA , 2018 , hsa_circ_0001953; hsa_circ_0009024 , Plasma , aTB vs HC , Arraystar circRNA Microarray , qRT-PCR , UP , 72.50% , 96.00% , 0.915(p < 0.001) , Preclinical , ( ) .

Techniques: Expressing, Binding Assay

Comprehensive ceRNA Interaction Networks and Regulatory Axes in GBM. A circRNA/lncRNA–miRNA–mRNA interaction network, illustrating the competitive binding relationships between ncRNAs and mRNAs. The size and color of the nodes represent the strength of interaction and their centrality within the network, respectively. B Regulatory axis network of circRNAs, illustrating the routes of circRNA-mediated control, from circRNAs to miRNAs and on to their mRNA targets. C Regulatory axis network of lncRNAs, outlining specific pathways of regulation from lncRNAs, through miRNAs, to their mRNA targets (color figure online)

Journal: Clinical and Experimental Medicine

Article Title: Integrative analysis of glioblastoma multiforme: the power of non-coding RNAs and hub genes in cancer research

doi: 10.1007/s10238-025-01677-0

Figure Lengend Snippet: Comprehensive ceRNA Interaction Networks and Regulatory Axes in GBM. A circRNA/lncRNA–miRNA–mRNA interaction network, illustrating the competitive binding relationships between ncRNAs and mRNAs. The size and color of the nodes represent the strength of interaction and their centrality within the network, respectively. B Regulatory axis network of circRNAs, illustrating the routes of circRNA-mediated control, from circRNAs to miRNAs and on to their mRNA targets. C Regulatory axis network of lncRNAs, outlining specific pathways of regulation from lncRNAs, through miRNAs, to their mRNA targets (color figure online)

Article Snippet: GSE165926 , circRNA , GPL21825 , Arraystar Human CircRNA microarray , 12/4 , China , 2021.

Techniques: Binding Assay, Control