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xenium prime 5k spatial transcriptomics  (Spatial Transcriptomics Inc)

 
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    Spatial Transcriptomics Inc xenium prime 5k spatial transcriptomics
    (A, C) Total and (B, D) virus-specific ASCs were quantified in the liver at week 4 post-infection for (A, B) RHV and (C, D) LCMV clone 13 infection with (E, F) representative ELISpot images showing (A, B) representative and (C, D) pooled data from (A-D) n = 2 independent experiments. Mice were either untreated (WT) or splenectomized and treated with FTY720 prior to infection with treatment being maintained throughout (splX + FTY720 [D -1]). Virus localization was determined by viral transcript density for individual portal and central zones at week 1 post-infection during (G) RHV and (H) LCMV clone 13 infection from n = 10 portal and n = 10 central zone selections from a Xenium 5 K spatial <t>transcriptomics</t> run of n = 1 mouse liver per group. Transcript density of genes associated with oxidative phosphorylation usage were quantified in (I) portal zone hepatocyte regions and (J) immature lymphocytic clusters at week 1 post-infection. Following (K) upstream staining, (L-O) individual transcript localization was determined in the liver at week 1 post-infection. (A-D, G-J) Mean + SEM. (A-D, G-J) Two-tailed, unpaired t-tests were performed. (A) p = 0.9168, (B) p = 0.1987, (C) p = 0.0008, (D) p < 0.0001, (G) p = 0.0261, (H) p = 0.0282. Statistical significance was denoted as *=(p ≤ 0.05), **=(p ≤ 0.01), ***=(p ≤ 0.001), and ****=(p ≤ 0.0001).
    Xenium Prime 5k Spatial Transcriptomics, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cell+spatial+transcriptomic+profiling/pmc12823446-119-26-29?v=Spatial+Transcriptomics+Inc
    Average 86 stars, based on 1 article reviews
    xenium prime 5k spatial transcriptomics - by Bioz Stars, 2026-08
    86/100 stars

    Images

    1) Product Images from "iHALT unlocks liver functionality as a surrogate secondary lymphoid organ"

    Article Title: iHALT unlocks liver functionality as a surrogate secondary lymphoid organ

    Journal: Nature

    doi: 10.1038/s41586-025-09803-4

    (A, C) Total and (B, D) virus-specific ASCs were quantified in the liver at week 4 post-infection for (A, B) RHV and (C, D) LCMV clone 13 infection with (E, F) representative ELISpot images showing (A, B) representative and (C, D) pooled data from (A-D) n = 2 independent experiments. Mice were either untreated (WT) or splenectomized and treated with FTY720 prior to infection with treatment being maintained throughout (splX + FTY720 [D -1]). Virus localization was determined by viral transcript density for individual portal and central zones at week 1 post-infection during (G) RHV and (H) LCMV clone 13 infection from n = 10 portal and n = 10 central zone selections from a Xenium 5 K spatial transcriptomics run of n = 1 mouse liver per group. Transcript density of genes associated with oxidative phosphorylation usage were quantified in (I) portal zone hepatocyte regions and (J) immature lymphocytic clusters at week 1 post-infection. Following (K) upstream staining, (L-O) individual transcript localization was determined in the liver at week 1 post-infection. (A-D, G-J) Mean + SEM. (A-D, G-J) Two-tailed, unpaired t-tests were performed. (A) p = 0.9168, (B) p = 0.1987, (C) p = 0.0008, (D) p < 0.0001, (G) p = 0.0261, (H) p = 0.0282. Statistical significance was denoted as *=(p ≤ 0.05), **=(p ≤ 0.01), ***=(p ≤ 0.001), and ****=(p ≤ 0.0001).
    Figure Legend Snippet: (A, C) Total and (B, D) virus-specific ASCs were quantified in the liver at week 4 post-infection for (A, B) RHV and (C, D) LCMV clone 13 infection with (E, F) representative ELISpot images showing (A, B) representative and (C, D) pooled data from (A-D) n = 2 independent experiments. Mice were either untreated (WT) or splenectomized and treated with FTY720 prior to infection with treatment being maintained throughout (splX + FTY720 [D -1]). Virus localization was determined by viral transcript density for individual portal and central zones at week 1 post-infection during (G) RHV and (H) LCMV clone 13 infection from n = 10 portal and n = 10 central zone selections from a Xenium 5 K spatial transcriptomics run of n = 1 mouse liver per group. Transcript density of genes associated with oxidative phosphorylation usage were quantified in (I) portal zone hepatocyte regions and (J) immature lymphocytic clusters at week 1 post-infection. Following (K) upstream staining, (L-O) individual transcript localization was determined in the liver at week 1 post-infection. (A-D, G-J) Mean + SEM. (A-D, G-J) Two-tailed, unpaired t-tests were performed. (A) p = 0.9168, (B) p = 0.1987, (C) p = 0.0008, (D) p < 0.0001, (G) p = 0.0261, (H) p = 0.0282. Statistical significance was denoted as *=(p ≤ 0.05), **=(p ≤ 0.01), ***=(p ≤ 0.001), and ****=(p ≤ 0.0001).

    Techniques Used: Virus, Infection, Enzyme-linked Immunospot, Phospho-proteomics, Staining, Two Tailed Test

    a – c , H&E staining of formalin-fixed, paraffin-embedded (FFPE) spleen ( a ) and mesenteric lymph node ( b ) sections at 4 weeks post-LCMV infection and a liver section at 4 weeks post-RHV infection ( c ). Regions of interest (ROIs) are enlarged on the right. One tissue sample from each condition was utilized for Visium HD spatial transcriptomics based on similar morphological H&E staining with limited interindividual variability for n = 4 ( a ), n = 4 ( b ) and n = 5 ( c ) mice. d – h , Visium HD spatial transcriptomic of slides shown in a – c . Individual transcript localization is shown as log 2 -scaled heat maps of 8-μm bins for Ms4a1 ( d ), H2afx ( e ), Cd3g ( f ), Ccl21a ( g ) and Xbp1 ( h ). i , Graph-based subclustering of clusters of interest from sections in a – c were manually annotated and cross-validated with ACT and PanglaoDB cell annotation databases. IFZ, interfollicular zone; SCS, subcapsular sinus. Colours indicate cell type and anatomical zones.
    Figure Legend Snippet: a – c , H&E staining of formalin-fixed, paraffin-embedded (FFPE) spleen ( a ) and mesenteric lymph node ( b ) sections at 4 weeks post-LCMV infection and a liver section at 4 weeks post-RHV infection ( c ). Regions of interest (ROIs) are enlarged on the right. One tissue sample from each condition was utilized for Visium HD spatial transcriptomics based on similar morphological H&E staining with limited interindividual variability for n = 4 ( a ), n = 4 ( b ) and n = 5 ( c ) mice. d – h , Visium HD spatial transcriptomic of slides shown in a – c . Individual transcript localization is shown as log 2 -scaled heat maps of 8-μm bins for Ms4a1 ( d ), H2afx ( e ), Cd3g ( f ), Ccl21a ( g ) and Xbp1 ( h ). i , Graph-based subclustering of clusters of interest from sections in a – c were manually annotated and cross-validated with ACT and PanglaoDB cell annotation databases. IFZ, interfollicular zone; SCS, subcapsular sinus. Colours indicate cell type and anatomical zones.

    Techniques Used: Staining, Formalin-fixed Paraffin-Embedded, Infection

    (A-F) Visium HD spatial transcriptomic outputs at 4 weeks post-RHV infection in the liver displayed as log2-scaled heatmaps of 8 μm bins for single-parameter panels and feature sums for multiple-parameter lists. (A) Transcripts characteristic of central zone (zone 3) are shown in orange ( Glul, Cyp2e1 ) while those characteristic of portal zone (zone 1) are shown in green ( Hal, Arg1 ). (B) Co-expression of central (orange) and portal (green) zone-related transcripts shown in (A) as combined feature sums. (C) Merged expression of central (red, Glul and Cyp2e1 ) and portal (green, Hal and Arg1 ) combined transcripts. (D) Expression of various plasma cell-related transcripts as shown in blue ( Xbp1 , Derlr3 , Jchain , Irf4 ). (E) Merged expression of transcripts indicative of the central zone (red, Glul and Cyp2e1 ) and plasma cells ( Xbp1 , Derl3 , Jchain , Irf4 ). (F) Merged expression of transcripts indicative of the portal zone (green, Hal and Arg1 ) and plasma cells ( Xbp1 , Derl3 , Jchain , Irf4 ). (F) Co-expression of plasma cell-related transcripts ( Xbp1 , Derl3 , Jchain , Irf4 ) as feature sum list. (A, F) From morphologically similar H&E staining with limited interindividual variability conducted on n = 5 mice, data is shown from n = 1 mouse liver tissue with which Visium HD spatial transcriptomics was conducted.
    Figure Legend Snippet: (A-F) Visium HD spatial transcriptomic outputs at 4 weeks post-RHV infection in the liver displayed as log2-scaled heatmaps of 8 μm bins for single-parameter panels and feature sums for multiple-parameter lists. (A) Transcripts characteristic of central zone (zone 3) are shown in orange ( Glul, Cyp2e1 ) while those characteristic of portal zone (zone 1) are shown in green ( Hal, Arg1 ). (B) Co-expression of central (orange) and portal (green) zone-related transcripts shown in (A) as combined feature sums. (C) Merged expression of central (red, Glul and Cyp2e1 ) and portal (green, Hal and Arg1 ) combined transcripts. (D) Expression of various plasma cell-related transcripts as shown in blue ( Xbp1 , Derlr3 , Jchain , Irf4 ). (E) Merged expression of transcripts indicative of the central zone (red, Glul and Cyp2e1 ) and plasma cells ( Xbp1 , Derl3 , Jchain , Irf4 ). (F) Merged expression of transcripts indicative of the portal zone (green, Hal and Arg1 ) and plasma cells ( Xbp1 , Derl3 , Jchain , Irf4 ). (F) Co-expression of plasma cell-related transcripts ( Xbp1 , Derl3 , Jchain , Irf4 ) as feature sum list. (A, F) From morphologically similar H&E staining with limited interindividual variability conducted on n = 5 mice, data is shown from n = 1 mouse liver tissue with which Visium HD spatial transcriptomics was conducted.

    Techniques Used: Infection, Expressing, Clinical Proteomics, Staining

    a – c , Visium HD spatial transcriptomics from liver tissue at four weeks post-RHV infection. a , Transcript feature sums of log 2 -scaled heat maps of 8-μm bins for osteopontin ( Spp1 ), Cxcl12 , type I collagen ( Col1a1 and Col1a2 ( Col1a1/2 )), Icam2 , fibronectin ( Fn1 ), Cd44 , Cxcr4 , CD138 ( Sdc1 ), LFA-1 ( Itga4 / Itgb1 ) and VLA-4 ( Itgal/Itgb7 ). b , Merged transcript localization of feature sum lists from a . c , H&E image with portal vein (blue) and central vein (yellow) ROIs (left) with associated transcript localization (right). d , Cartoon diagram representing plausible molecular factors responsible for intrahepatic plasma cell retention. LSEC, liver sinusoidal endothelial cell. Created in BioRender. Grakoui, A. (2025) https://BioRender.com/ppmu1j5 . e , f , Intrahepatic total ( e ) and E2-specific ( f ) ASCs at 4 weeks post-infection with or without acute blockade of anchoring molecules at days 26 and 27 post-infection. AMD, AMD3100; anti-V/L, anti-VLA-4 plus anti-LFA-1; anti-V/L/S, anti-VLA-4, anti-LFA-1 plus anti-SPP1. n = 2 independent experiments. Control versus anti-V/L + AMD: P = 0.0003 ( e ), P = 0.0182 ( f ). g – i , Xenium Prime 5K spatial transcriptomics on liver tissue at three weeks post-infection with upstream morphological staining ( g ), virus, vasculature and plasma cell transcript localization ( h ), and virus, GC-associated and plasma cell transcript localization in periportal regions ( i ). j , RHV RNA in serum plotted against intrahepatic E2-specific ASC frequencies at four weeks post-infection. μMT, B6.129S2-Ighmtm1Cgn/J mice lacking mature B cells; dpi, days post infection. k , l , Bulk IgH BCR sequencing at 4 weeks post-infection from n = 3 RHV-infected mice, n = 3 LCMV-infected mice and n = 1 naive mouse. SHM accrual is plotted as nucleotide divergence from germline sequences among distinct clonotypes ( k ) and IgH V–J gene pairing chord diagrams ( l ). m – o , Intrahepatic common Igkc transcript localization alongside unique Igkv gene family transcripts with upstream morphological staining ( m ) and segmented cell borders showing transcript localization of Igkc with Igkv4-51 ( n ) and Igkc with Igkv15-103 ( o ). e , f , j , Data are representative or pooled values from at least two independent experiments of at least three mice per group. e , f , k , Data are mean + s.e.m. One-way ANOVA with Tukey’s multiple comparisons test ( e , f , k ); two-tailed nonparametric Spearman correlations with Pearson’s r ( j ).
    Figure Legend Snippet: a – c , Visium HD spatial transcriptomics from liver tissue at four weeks post-RHV infection. a , Transcript feature sums of log 2 -scaled heat maps of 8-μm bins for osteopontin ( Spp1 ), Cxcl12 , type I collagen ( Col1a1 and Col1a2 ( Col1a1/2 )), Icam2 , fibronectin ( Fn1 ), Cd44 , Cxcr4 , CD138 ( Sdc1 ), LFA-1 ( Itga4 / Itgb1 ) and VLA-4 ( Itgal/Itgb7 ). b , Merged transcript localization of feature sum lists from a . c , H&E image with portal vein (blue) and central vein (yellow) ROIs (left) with associated transcript localization (right). d , Cartoon diagram representing plausible molecular factors responsible for intrahepatic plasma cell retention. LSEC, liver sinusoidal endothelial cell. Created in BioRender. Grakoui, A. (2025) https://BioRender.com/ppmu1j5 . e , f , Intrahepatic total ( e ) and E2-specific ( f ) ASCs at 4 weeks post-infection with or without acute blockade of anchoring molecules at days 26 and 27 post-infection. AMD, AMD3100; anti-V/L, anti-VLA-4 plus anti-LFA-1; anti-V/L/S, anti-VLA-4, anti-LFA-1 plus anti-SPP1. n = 2 independent experiments. Control versus anti-V/L + AMD: P = 0.0003 ( e ), P = 0.0182 ( f ). g – i , Xenium Prime 5K spatial transcriptomics on liver tissue at three weeks post-infection with upstream morphological staining ( g ), virus, vasculature and plasma cell transcript localization ( h ), and virus, GC-associated and plasma cell transcript localization in periportal regions ( i ). j , RHV RNA in serum plotted against intrahepatic E2-specific ASC frequencies at four weeks post-infection. μMT, B6.129S2-Ighmtm1Cgn/J mice lacking mature B cells; dpi, days post infection. k , l , Bulk IgH BCR sequencing at 4 weeks post-infection from n = 3 RHV-infected mice, n = 3 LCMV-infected mice and n = 1 naive mouse. SHM accrual is plotted as nucleotide divergence from germline sequences among distinct clonotypes ( k ) and IgH V–J gene pairing chord diagrams ( l ). m – o , Intrahepatic common Igkc transcript localization alongside unique Igkv gene family transcripts with upstream morphological staining ( m ) and segmented cell borders showing transcript localization of Igkc with Igkv4-51 ( n ) and Igkc with Igkv15-103 ( o ). e , f , j , Data are representative or pooled values from at least two independent experiments of at least three mice per group. e , f , k , Data are mean + s.e.m. One-way ANOVA with Tukey’s multiple comparisons test ( e , f , k ); two-tailed nonparametric Spearman correlations with Pearson’s r ( j ).

    Techniques Used: Infection, Clinical Proteomics, Control, Staining, Virus, Sequencing, Two Tailed Test

    (A) Number of total IgG + ASCs in the liver at week 4 post-RHV infection following splenectomy one week prior to infection or FTY720 administration beginning at day 11 post-infection onward with representative ELISpot image. (B) Correlation between % plasma cells (CD38 low CD138 + of total B cells) and % GC B cells (CD38 low CD95 + of total B cells) in the liver at 4 weeks post-infection with RHV. (C) Representative H&E staining of FFPE sections from spleen at week 4 post-LCMV infection and liver at week 4 post-RHV infection. (D) Immunofluorescence staining of FFPE sections at 4 weeks post-RHV infection. Localization of representative Ig kappa gene families displayed as log2-scaled heatmaps of 8 μm bins at 4 weeks post-infection in (E) spleen (LCMV), (F) mesenteric lymph nodes (LCMV) and (G) liver (RHV). (H) From liver tissue at 4 weeks post-infection with RHV following FTY720 treatment, H&E (top) is shown for corresponding ROIs where Igkv19–93 localization is shown as log2-scaled heatmaps of 8 μm bins (bottom). (I) Correlation between intrahepatic CD38 low CD95 + GC B cells and RHV serum viremia at 4 weeks post-infection. (A-B) Data shown are representative or pooled values from 2-3 independent experiments of 3–9 mice per group. Visium HD spatial transcriptomics was conducted with liver tissue from n = 1 representative mouse following similar H&E morphological staining with limited interindividual variability from (C) n = 4 (spleen) and n = 4 (liver), (E) n = 4, (F) n = 4, (G) n = 5, and (H) n = 4 mice. (D) Representative image shown from immunofluorescent staining that was performed with liver tissue from n = 4 mice. (A) Mean + SEM. Statistical tests performed were (A) one-way ANOVA with Tukey’s multiple comparisons test and (B, I) two-tailed nonparametric Spearman correlation with Pearson’s r coefficient. (A) Uninfected vs. WT: p < 0.0001, WT vs. FTY720 D + 11: p = 0.9939, FTY720 D + 11 vs. Splenectomy: p = 0.9853. Statistical significance was denoted as ****=(p ≤ 0.0001).
    Figure Legend Snippet: (A) Number of total IgG + ASCs in the liver at week 4 post-RHV infection following splenectomy one week prior to infection or FTY720 administration beginning at day 11 post-infection onward with representative ELISpot image. (B) Correlation between % plasma cells (CD38 low CD138 + of total B cells) and % GC B cells (CD38 low CD95 + of total B cells) in the liver at 4 weeks post-infection with RHV. (C) Representative H&E staining of FFPE sections from spleen at week 4 post-LCMV infection and liver at week 4 post-RHV infection. (D) Immunofluorescence staining of FFPE sections at 4 weeks post-RHV infection. Localization of representative Ig kappa gene families displayed as log2-scaled heatmaps of 8 μm bins at 4 weeks post-infection in (E) spleen (LCMV), (F) mesenteric lymph nodes (LCMV) and (G) liver (RHV). (H) From liver tissue at 4 weeks post-infection with RHV following FTY720 treatment, H&E (top) is shown for corresponding ROIs where Igkv19–93 localization is shown as log2-scaled heatmaps of 8 μm bins (bottom). (I) Correlation between intrahepatic CD38 low CD95 + GC B cells and RHV serum viremia at 4 weeks post-infection. (A-B) Data shown are representative or pooled values from 2-3 independent experiments of 3–9 mice per group. Visium HD spatial transcriptomics was conducted with liver tissue from n = 1 representative mouse following similar H&E morphological staining with limited interindividual variability from (C) n = 4 (spleen) and n = 4 (liver), (E) n = 4, (F) n = 4, (G) n = 5, and (H) n = 4 mice. (D) Representative image shown from immunofluorescent staining that was performed with liver tissue from n = 4 mice. (A) Mean + SEM. Statistical tests performed were (A) one-way ANOVA with Tukey’s multiple comparisons test and (B, I) two-tailed nonparametric Spearman correlation with Pearson’s r coefficient. (A) Uninfected vs. WT: p < 0.0001, WT vs. FTY720 D + 11: p = 0.9939, FTY720 D + 11 vs. Splenectomy: p = 0.9853. Statistical significance was denoted as ****=(p ≤ 0.0001).

    Techniques Used: Infection, Enzyme-linked Immunospot, Clinical Proteomics, Staining, Immunofluorescence, Two Tailed Test

    a , b , Xenium Prime 5K spatial transcriptomics of liver tissue from healthy, AIH, HBV-infected and HCV-infected humans with upstream staining ( a ) and selected transcript localization ( b ). c – g , Quantitative analyses from spatial transcriptomics demonstrating number of leukocytic aggregates per mm 2 of tissue ( c ), aggregate area of leukocytic aggregates ( d ), and lymphocytic cell-type proportions of B cells ( e ), CD4 + T cells ( f ) and CD8 + T cells ( g ) observed in leukocytic aggregates from individuals with AIH ( n = 1), chronic HBV ( n = 2) and chronic HCV ( n = 2) infection. Data are mean + s.e.m. d – g , One-way ANOVA with Tukey’s multiple comparisons test. AIH versus HBV: P = 0.0101 ( g ). h , Quantification of cell types and their direct contact partners within leukocytic aggregates from annotated spatial transcriptomics with subcellular resolution and cell segmentation during mouse RHV (orange) and human HCV (blue) infection. HSC, hepatic stellate cell. i – n , RHV-infected mouse liver ( i , k , m ) and HCV-infected human liver ( j , l , n ) tissue. Generative GC-like structures were characterized upstream staining ( i , j ) and GC-associated transcript localization ( k , l ) and colour-coded cell-type annotation with selected overlaid transcripts ( m , n ). o – t , RHV-infected mouse liver ( o , q , s ) and HCV-infected human liver ( p , r , t ) tissue. Areas of intrahepatic plasma cell residency were characterized by upstream staining ( o , p ) and plasma cell and hepatic stellate cell and fibroblast-associated transcripts ( q , r ) with colour-coded cell-type annotation ( s , t ). Based on similar morphological H&E staining with limited interindividual variability of n = 2 HCV-infected humans and n = 4 RHV-infected mice, Xenium 5K was performed on tissue from n = 2 human and n = 1 mouse livers, from which n = 1 representative tissue of each are shown in i – t .
    Figure Legend Snippet: a , b , Xenium Prime 5K spatial transcriptomics of liver tissue from healthy, AIH, HBV-infected and HCV-infected humans with upstream staining ( a ) and selected transcript localization ( b ). c – g , Quantitative analyses from spatial transcriptomics demonstrating number of leukocytic aggregates per mm 2 of tissue ( c ), aggregate area of leukocytic aggregates ( d ), and lymphocytic cell-type proportions of B cells ( e ), CD4 + T cells ( f ) and CD8 + T cells ( g ) observed in leukocytic aggregates from individuals with AIH ( n = 1), chronic HBV ( n = 2) and chronic HCV ( n = 2) infection. Data are mean + s.e.m. d – g , One-way ANOVA with Tukey’s multiple comparisons test. AIH versus HBV: P = 0.0101 ( g ). h , Quantification of cell types and their direct contact partners within leukocytic aggregates from annotated spatial transcriptomics with subcellular resolution and cell segmentation during mouse RHV (orange) and human HCV (blue) infection. HSC, hepatic stellate cell. i – n , RHV-infected mouse liver ( i , k , m ) and HCV-infected human liver ( j , l , n ) tissue. Generative GC-like structures were characterized upstream staining ( i , j ) and GC-associated transcript localization ( k , l ) and colour-coded cell-type annotation with selected overlaid transcripts ( m , n ). o – t , RHV-infected mouse liver ( o , q , s ) and HCV-infected human liver ( p , r , t ) tissue. Areas of intrahepatic plasma cell residency were characterized by upstream staining ( o , p ) and plasma cell and hepatic stellate cell and fibroblast-associated transcripts ( q , r ) with colour-coded cell-type annotation ( s , t ). Based on similar morphological H&E staining with limited interindividual variability of n = 2 HCV-infected humans and n = 4 RHV-infected mice, Xenium 5K was performed on tissue from n = 2 human and n = 1 mouse livers, from which n = 1 representative tissue of each are shown in i – t .

    Techniques Used: Infection, Staining, Clinical Proteomics

    Xenium Prime 5 K spatial transcriptomics was performed with liver tissue obtained during human (A, B) AIH and (C, D) HBV infection. Depicted are regions of interest showing (A, C) upstream morphological staining and (B, D) expression of various color-coded transcripts and annotated cell types. Data shown from (A, B) n = 1 individual with AIH and (C, D) n = 1 individual chronically infected with HBV from which liver tissue was selected for spatial transcriptomics conducted on (A, B) n = 1 individual and (C, D) n = 2 individuals with limited interindividual variability.
    Figure Legend Snippet: Xenium Prime 5 K spatial transcriptomics was performed with liver tissue obtained during human (A, B) AIH and (C, D) HBV infection. Depicted are regions of interest showing (A, C) upstream morphological staining and (B, D) expression of various color-coded transcripts and annotated cell types. Data shown from (A, B) n = 1 individual with AIH and (C, D) n = 1 individual chronically infected with HBV from which liver tissue was selected for spatial transcriptomics conducted on (A, B) n = 1 individual and (C, D) n = 2 individuals with limited interindividual variability.

    Techniques Used: Infection, Staining, Expressing



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    Image Search Results


    Comparisons of different single-cell transcriptomic techniques.

    Journal: Frontiers in Neural Circuits

    Article Title: Recent advances in understanding neuronal diversity and neural circuit complexity across different brain regions using single-cell sequencing

    doi: 10.3389/fncir.2023.1007755

    Figure Lengend Snippet: Comparisons of different single-cell transcriptomic techniques.

    Article Snippet: Single-cell transcriptome profiling technology (spatial transcriptomics) , Single cell level , MERFISH , Currently up to 500 selected genes , All cell types , Fresh frozen, PFA-fixed frozen tissue, paraffin-embedded tissue.

    Techniques: RNA Sequencing, Formalin-fixed Paraffin-Embedded

    Neuronal diversity across different brain regions revealed by single-cell transcriptomic studies. Most recent literature about neuronal transcriptomes have investigated neuron subpopulations from prefrontal cortex, hippocampus, and hypothalamus. Relevant details have been also described in . IT, intratelencephalic-projecting neurons; ET, extratelencephalic-projecting neurons; NP, near-projecting neurons; CT, corticothalamic projecting neurons.

    Journal: Frontiers in Neural Circuits

    Article Title: Recent advances in understanding neuronal diversity and neural circuit complexity across different brain regions using single-cell sequencing

    doi: 10.3389/fncir.2023.1007755

    Figure Lengend Snippet: Neuronal diversity across different brain regions revealed by single-cell transcriptomic studies. Most recent literature about neuronal transcriptomes have investigated neuron subpopulations from prefrontal cortex, hippocampus, and hypothalamus. Relevant details have been also described in . IT, intratelencephalic-projecting neurons; ET, extratelencephalic-projecting neurons; NP, near-projecting neurons; CT, corticothalamic projecting neurons.

    Article Snippet: Single-cell transcriptome profiling technology (spatial transcriptomics) , Single cell level , MERFISH , Currently up to 500 selected genes , All cell types , Fresh frozen, PFA-fixed frozen tissue, paraffin-embedded tissue.

    Techniques: