Injection:Article Title: Induction of HLA-B27–Associated Reactive Arthritis After a Wharton’s Jelly “Stem Cell” Injection
Article Snippet: Orthobiologic injections are an emerging treatment option for musculoskeletal conditions.. Allogenic gestational tissue–derived products, including umbilical cord–derived Wharton’s jelly, are among the available options.. These tissues are currently being harvested and sold by companies as an off-the-shelf “stem cell” injection for conditions such as back pain and osteoarthritis.
Irradiation:Article Title: Therapeutic Efficacy of Adipose-Derived Stem Cells Versus Bone Marrow Stromal Cells for Irradiated Mandibular Fracture Repair
Article Snippet: Background:Mesenchymal stem cells have immense potential in applications of bone healing and regeneration.. However, few studies have evaluated the therapeutic efficacy of adipose-derived stem cells (ASCs) and bone marrow stromal cells (BMSCs) in irradiated bone.. The purpose of this study is to compare the ability of ASCs versus BMSCs to enhance healing outcomes in a murine model of irradiated mandibular fracture repair.
Ubiquitin Proteomics:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Disruption:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Gene Expression:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Knockdown:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Knock-Out:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Activation Assay:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Over Expression:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
Expressing:Article Title: Targeting the cGAS-STING Pathway: An Emerging Therapeutic Strategy for Digestive Diseases.
Article Snippet: Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology Liver HBV interacting with STING and inhibiting ubiquitination at its K63 site HepaRG cells primary human hepatocytes HBV replication was significantly inhibited when the cGAS-STING pathway was activated by either dsDNA or cGAMP cancer patients, mice STING activated [40] NAFLD STING levels in non-solid cells of liver tissue were higher in NAFLD patients than in non-NAFLD patients. mice with disruption of Tmem173 STING activated [115] NASH STING deficiency attenuates hepatic steatosis, fibrosis and inflammation in two NASH mouse models NASH in mice STING inhibited [48] ALD Disruption of Cx32 impairs IRF3 gene expression ALD patient Cx32KO mice STING inhibited [51] IRI Knockdown of STING in macrophages significantly attenuates aging-related deterioration of hepatic IRIs C57/BL6 mice STING inhibited [54] Liver fibrosis XBP1 regulates macrophage mtDNA cytoplasmic leakage via BNIP3-mediated regulation of mitochondrial autophagy to activate macrophage cGAS/STING/NLRP3 and exacerbate liver fibrosis mice and patients with Xbp1 knockout XBP1/STING/NLRP3 activated [62] Fluoropropylene oxide trimeric acid (HFPO-TA) mediates cellular cGAS/STING/NLRP3 activation through mitochondrial ROS (mtROS) overexpression and accelerates liver fibrosis progression C57/BL6 mice STING/NLRP3 activated [63] Hepatocellular Carcinoma TET2-mediated IL-2/STAT5A signaling upregulates cGAS expression in hepatocellular carcinoma tumors and produces cGAMP. cGAMP is Hepa1-6 Huh7 TET2/IL-2/STAT5A/ STING activated [66] Copyright ©2026 The Author(s). .. Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology transported through LRRC8C channels to activate STING in endothelial cells Pancreatic Acute pancreatitis STING is activated by sensing PAC death and promotes inflammatory cytokine and IFN production, exacerbating AP severity C57BL/6J mice C57BL/6J-Tmem 173gt/J mice TMEM 173/STING activated [74] Knockdown of wip 1 inhibits the STING-TBK 1 signaling pathway, suppresses AP autophagy, and reduces AP severity 28-week-old male SD rats Wip1/STING inhibited [77] Inhibition of the pro-inflammatory factor enhancer JMJD3 blocked mtDNA oxidation and knocked down the TLR 9/STING pathway effectively reduced inflammation C57BL/6 mice(M) JMJD3/TLR9/STING inhibited [75] SSd protects PAC from rainfroggin-induced pyroptosis by attenuating mitochondrial damage and inhibiting the cGAS-STING signaling pathway, attenuating AP AR42J cell line SSd/STING inhibited [76] Chronic Pancreatitis DMXAA activates STING signaling and limits Th 17 response in the pancreas, significantly relieving CP symptoms C57BL/6J mice, C57BL/6J-Tmem 173gt/J mice DMXAA/STING activated [79] Pancreatic cancer Inhibition of DTX 3L leads to enhanced activation of cGAS-STING signaling pathway and improves anti-tumor immunity in pancreatic cancer C57BL/6J mice(F) DTX3L/STING activated [88] Colorectal Ulcerative colitis PAD4-mediated NETs activate the cGAS-STING pathway in a dose- and time-dependent manner, leading to the secretion of inflammatory cytokines and impaired barrier function C57BL/6 mice PAD4/NETs/STING activated [101] ANP repairs the intestinal barrier and inhibits ER stress-induced autophagy by inhibiting STING 8week-old C57BL/6 mice(M) ANP/STING inhibited [94] Copyright ©2026 The Author(s).
other:Article Title: The role of eye banking with cell-based therapies
Article Snippet: Eye banks have played an integral role in the advancement of corneal transplantation since the first eye bank was established in 1944 by R. Townley Paton.. Throughout the 20th century, penetrating keratoplasty was the standard of care for treating corneal diseases, and eye banks helped to recover, evaluate, and distribute donor corneas [1].. Over the last two decades, there has been a rapid evolution in corneal transplantation from full-thickness penetrating keratoplasty to partial-thickness lamellar keratoplasty, namely, endothelial keratoplasty.
|
