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bleomycin blm  (Merck KGaA)

 
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    Structured Review

    Merck KGaA bleomycin blm
    Effect of SPHE on MDA (a) NO (b) TSH (c) and GSH (d) levels in the lung tissue of <t>BLM-induced</t> pulmonary fibrosis rats. The results are reported as Mean ± SD, ( n = 7). ( ∗∗∗ p < 0.001, control vs <t>Bleomycin</t> group). ( ### p < 0.001, Bleomycin vs Vitamin E ### p < 0.001, Bleomycin vs S.P 300 and S.P 600) ( ## p < 0.01, Bleomycin vs Vitamin E ## p < 0.01, Bleomycin vs S.P 300 # p < 0.01, Bleomycin vs S.P 600).
    Bleomycin Blm, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/bleomycin+blm/bleomycin+blm/pmc10697776-37-0-25
    Average 90 stars, based on 1 article reviews
    bleomycin blm - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Stachys pilifera Benth. Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through the Antioxidant Pathways"

    Article Title: Stachys pilifera Benth. Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through the Antioxidant Pathways

    Journal: Evidence-based Complementary and Alternative Medicine : eCAM

    doi: 10.1155/2022/6208102

    Effect of SPHE on MDA (a) NO (b) TSH (c) and GSH (d) levels in the lung tissue of BLM-induced pulmonary fibrosis rats. The results are reported as Mean ± SD, ( n = 7). ( ∗∗∗ p < 0.001, control vs Bleomycin group). ( ### p < 0.001, Bleomycin vs Vitamin E ### p < 0.001, Bleomycin vs S.P 300 and S.P 600) ( ## p < 0.01, Bleomycin vs Vitamin E ## p < 0.01, Bleomycin vs S.P 300 # p < 0.01, Bleomycin vs S.P 600).
    Figure Legend Snippet: Effect of SPHE on MDA (a) NO (b) TSH (c) and GSH (d) levels in the lung tissue of BLM-induced pulmonary fibrosis rats. The results are reported as Mean ± SD, ( n = 7). ( ∗∗∗ p < 0.001, control vs Bleomycin group). ( ### p < 0.001, Bleomycin vs Vitamin E ### p < 0.001, Bleomycin vs S.P 300 and S.P 600) ( ## p < 0.01, Bleomycin vs Vitamin E ## p < 0.01, Bleomycin vs S.P 300 # p < 0.01, Bleomycin vs S.P 600).

    Techniques Used: Control

    Effect of SPHE on MDA (a) NO (b) FRAP (c) and TSH (d) levels in serum of BLM-induced pulmonary fibrosis rats. The results are reported as mean ± SD, ( n = 7). ( ∗∗∗ p < 0.001, control vs Bleomycin group). ( ### p < 0.001, Bleomycin vs Vitamin E ### p < 0.001, Bleomycin vs S.P 300 and S.P 600) ( ## p < 0.01, Bleomycin vs Vitamin E ## p < 0.01, Bleomycin vs S.P 300 and S.P).
    Figure Legend Snippet: Effect of SPHE on MDA (a) NO (b) FRAP (c) and TSH (d) levels in serum of BLM-induced pulmonary fibrosis rats. The results are reported as mean ± SD, ( n = 7). ( ∗∗∗ p < 0.001, control vs Bleomycin group). ( ### p < 0.001, Bleomycin vs Vitamin E ### p < 0.001, Bleomycin vs S.P 300 and S.P 600) ( ## p < 0.01, Bleomycin vs Vitamin E ## p < 0.01, Bleomycin vs S.P 300 and S.P).

    Techniques Used: Control

    Effect of SPHE on hydroxyproline content in the liver tissue of BLM-induced pulmonary fibrosis rats. The results are reported as mean ± SD, ( n = 7). ( ∗∗∗ p < 0.001, control vs Bleomycin group). ( ### p < 0.001, Bleomycin vs Vitamin E ### p < 0.001, Bleomycin vs S.P 300 and S.P 600).
    Figure Legend Snippet: Effect of SPHE on hydroxyproline content in the liver tissue of BLM-induced pulmonary fibrosis rats. The results are reported as mean ± SD, ( n = 7). ( ∗∗∗ p < 0.001, control vs Bleomycin group). ( ### p < 0.001, Bleomycin vs Vitamin E ### p < 0.001, Bleomycin vs S.P 300 and S.P 600).

    Techniques Used: Control

    Related Articles

    Control:

    Article Title: Stachys pilifera Benth. Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through the Antioxidant Pathways
    Article Snippet: Bleomycin (BLM), 2,4,6-tri(2-pyridyl)-1,3,5-triazine (TPTZ), sulfanilamide, n-(1-naphthyl) ethylenediamine dihydrochloride, thiobarbituric acid (TBA), trichloroacetic acid (TCA), ethylenediaminetetraacetic acid (EDTA) and 5,5′-dithiobis (2-nitrobenzoic acid) (DTNB) were purchased from Merk- Germany.



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    Effects of QFHXD on histopathology and pro-fibrotic markers in <t>BLM-induced</t> PF mice. ( A ) Dynamic changes in body weight. ( B ) The Kaplan-Meier survival curve of each group. Compared with the model group, Treatment with different doses of QFHXD markedly boosted the survival rate of PF mice. ( C ) The representative images of lung sections stained with H&E, Masson’s trichrome, and immunohistochemical staining for α-SMA and FN proteins (×200 magnification, scale bar: 100 μm, n = 6). ( D ) Ashcroft score for grading PF severity (n = 6). Quantification of immunohistochemical results of α-SMA ( E ) and FN ( F ) expression (n = 6). The relative mRNA levels of Fn1 ( G ) and Col1a1 ( H ) in lung samples of each group (n = 5). QFHXD administration effectively mitigated fibrotic lesions, inhibited collagen deposition, and decreased the expression of pro-fibrotic markers. Serum levels <t>of</t> <t>TGF-β1</t> ( I ), CCL2 ( J ), and KL-6 ( K ) were measured by ELISA (n = 8). Data are displayed as the mean ± SD. ## P < 0.01 versus the control group; * P < 0.05, and ** P < 0.01 versus the model group. Model, BLM-induced PF model; QFHXD-L, QFHXD low dose (4.78 g/kg); QFHXD-H, QFHXD high dose (9.56 g/kg).
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    Image Search Results


    Effects of QFHXD on histopathology and pro-fibrotic markers in BLM-induced PF mice. ( A ) Dynamic changes in body weight. ( B ) The Kaplan-Meier survival curve of each group. Compared with the model group, Treatment with different doses of QFHXD markedly boosted the survival rate of PF mice. ( C ) The representative images of lung sections stained with H&E, Masson’s trichrome, and immunohistochemical staining for α-SMA and FN proteins (×200 magnification, scale bar: 100 μm, n = 6). ( D ) Ashcroft score for grading PF severity (n = 6). Quantification of immunohistochemical results of α-SMA ( E ) and FN ( F ) expression (n = 6). The relative mRNA levels of Fn1 ( G ) and Col1a1 ( H ) in lung samples of each group (n = 5). QFHXD administration effectively mitigated fibrotic lesions, inhibited collagen deposition, and decreased the expression of pro-fibrotic markers. Serum levels of TGF-β1 ( I ), CCL2 ( J ), and KL-6 ( K ) were measured by ELISA (n = 8). Data are displayed as the mean ± SD. ## P < 0.01 versus the control group; * P < 0.05, and ** P < 0.01 versus the model group. Model, BLM-induced PF model; QFHXD-L, QFHXD low dose (4.78 g/kg); QFHXD-H, QFHXD high dose (9.56 g/kg).

    Journal: Drug Design, Development and Therapy

    Article Title: Integrated Serum Pharmacochemistry, Network Pharmacology, and Transcriptomics Reveal the Mechanisms and Active Constituents of Qingfei Huoxue Decoction Against Bleomycin-Induced Pulmonary Fibrosis

    doi: 10.2147/DDDT.S592770

    Figure Lengend Snippet: Effects of QFHXD on histopathology and pro-fibrotic markers in BLM-induced PF mice. ( A ) Dynamic changes in body weight. ( B ) The Kaplan-Meier survival curve of each group. Compared with the model group, Treatment with different doses of QFHXD markedly boosted the survival rate of PF mice. ( C ) The representative images of lung sections stained with H&E, Masson’s trichrome, and immunohistochemical staining for α-SMA and FN proteins (×200 magnification, scale bar: 100 μm, n = 6). ( D ) Ashcroft score for grading PF severity (n = 6). Quantification of immunohistochemical results of α-SMA ( E ) and FN ( F ) expression (n = 6). The relative mRNA levels of Fn1 ( G ) and Col1a1 ( H ) in lung samples of each group (n = 5). QFHXD administration effectively mitigated fibrotic lesions, inhibited collagen deposition, and decreased the expression of pro-fibrotic markers. Serum levels of TGF-β1 ( I ), CCL2 ( J ), and KL-6 ( K ) were measured by ELISA (n = 8). Data are displayed as the mean ± SD. ## P < 0.01 versus the control group; * P < 0.05, and ** P < 0.01 versus the model group. Model, BLM-induced PF model; QFHXD-L, QFHXD low dose (4.78 g/kg); QFHXD-H, QFHXD high dose (9.56 g/kg).

    Article Snippet: BLM (99.03%, HY-17565), human TGF-β1 protein (HY-P7118), and SB-431542 (HY-10431) were obtained from MedChemExpress.

    Techniques: Histopathology, Staining, Immunohistochemical staining, Expressing, Enzyme-linked Immunosorbent Assay, Control

    Experimental validation of inflammatory targets regulated by QFHXD in BLM-induced PF. ( A and B ) The relative mRNA levels of key inflammatory targets obtained from network pharmacology and RNA-Seq analysis, including Tlr2, Tlr4, Rela, Nfkb1, Il1b, Il6, Tnf, Tgfb1, Ccl2, Spp1, Mmp9, Mmp13, and Mmp14 (n = 5). The concentrations of TLR2 ( C ), TLR4 ( D ), NF-κB ( E ), IL-1β ( F ), IL-6 ( G ), TNF-α ( H ), TGF-β1 ( I ), CCL2 ( J ), and SPP1 ( K ) proteins were investigated by ELISA (n = 6). ( L ) The typical images of immunohistochemical staining of MMP9 protein in each group (×200 magnification, scale bar: 100 μm, n = 6). Black arrows indicated MMP9-positive cells. ( M ) Quantification of MMP9-positive cells (n = 6). Compared with the untreated PF model group, QFHXD intervention significantly suppressed the mRNA and protein expression of pro-inflammatory mediators in fibrotic lung samples. RT-qPCR results are expressed as the mean ± SEM. Data of ELISA and immunohistochemical staining are displayed as the mean ± SD. ## P < 0.01 versus the control group; * P < 0.05, and ** P < 0.01 versus the model group. Model, BLM-induced PF model; QFHXD-L, QFHXD low dose (4.78 g/kg); QFHXD-H, QFHXD high dose (9.56 g/kg).

    Journal: Drug Design, Development and Therapy

    Article Title: Integrated Serum Pharmacochemistry, Network Pharmacology, and Transcriptomics Reveal the Mechanisms and Active Constituents of Qingfei Huoxue Decoction Against Bleomycin-Induced Pulmonary Fibrosis

    doi: 10.2147/DDDT.S592770

    Figure Lengend Snippet: Experimental validation of inflammatory targets regulated by QFHXD in BLM-induced PF. ( A and B ) The relative mRNA levels of key inflammatory targets obtained from network pharmacology and RNA-Seq analysis, including Tlr2, Tlr4, Rela, Nfkb1, Il1b, Il6, Tnf, Tgfb1, Ccl2, Spp1, Mmp9, Mmp13, and Mmp14 (n = 5). The concentrations of TLR2 ( C ), TLR4 ( D ), NF-κB ( E ), IL-1β ( F ), IL-6 ( G ), TNF-α ( H ), TGF-β1 ( I ), CCL2 ( J ), and SPP1 ( K ) proteins were investigated by ELISA (n = 6). ( L ) The typical images of immunohistochemical staining of MMP9 protein in each group (×200 magnification, scale bar: 100 μm, n = 6). Black arrows indicated MMP9-positive cells. ( M ) Quantification of MMP9-positive cells (n = 6). Compared with the untreated PF model group, QFHXD intervention significantly suppressed the mRNA and protein expression of pro-inflammatory mediators in fibrotic lung samples. RT-qPCR results are expressed as the mean ± SEM. Data of ELISA and immunohistochemical staining are displayed as the mean ± SD. ## P < 0.01 versus the control group; * P < 0.05, and ** P < 0.01 versus the model group. Model, BLM-induced PF model; QFHXD-L, QFHXD low dose (4.78 g/kg); QFHXD-H, QFHXD high dose (9.56 g/kg).

    Article Snippet: BLM (99.03%, HY-17565), human TGF-β1 protein (HY-P7118), and SB-431542 (HY-10431) were obtained from MedChemExpress.

    Techniques: Biomarker Discovery, RNA Sequencing, Enzyme-linked Immunosorbent Assay, Immunohistochemical staining, Staining, Expressing, Quantitative RT-PCR, Control