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Spectral Genomics Inc bacterial artificial chromosome (bac) array chips
Bacterial Artificial Chromosome (Bac) Array Chips, supplied by Spectral Genomics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bac+array/human+bac+array+system/pmc02920185-30-11-19
Average 90 stars, based on 1 article reviews
bacterial artificial chromosome (bac) array chips - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Benign copy number changes in clinical cytogenetic diagnostics by array CGH
Article Snippet: The University of Utah Cytogenetics/Microarray Laboratory data include results from two bacterial artificial chromosome (BAC) array chips purchased from Spectral Genomics Inc./PerkinElmer (SGI/PE) (Turku, Finland): the Constitutional ChipTM (CC) and the SpectralChip 2600TM (1Mb).

Article Title: Comprehensive validation of array comparative genomic hybridization platforms: how much is enough?
Article Snippet: Clinical testing using various array comparative genomic hybridization platforms is being incorporated rapidly into cytogenetic testing algorithms.. Comprehensive validation of these complex assays presents unique challenges and very few studies reporting the validation of commercially available array platforms have been published.. Sixty-seven patients with previously defined subtelomere abnormalities, representing deletions and/or duplications of all 41 clinically relevant sites, were tested in a blinded study using the Spectral Genomics Constitutional Chip 3.0.

Article Title: Complex rearrangement of chromosomes 7q21.13-q22.1 confirms the ectrodactyly-deafness locus and suggests new candidate genes.
Article Snippet: Clinical Report Complex Rearrangement of Chromosome 7q21.13q22.1 Confirms the Ectrodactyly-Deafness Locus and Suggests New Candidate Genes Laura Bernardini,* Chiara Palka, Caterina Ceccarini, Anna Capalbo, Irene Bottillo, Rita Mingarelli, Antonio Novelli, and Bruno Dallapiccola CSS-Hospital, San Giovanni Rotondo and CSS-Mendel Institute, Rome, Italy Experimental Medicine Department, ‘‘La Sapienza’’ University, Rome, Italy

Article Title: De novo subtelomeric deletion additional to an inherited apparently balanced reciprocal translocation.
Article Snippet: Objective: We describe the analysis of an apparently balanced inherited reciprocal translocation in a fetus presenting with multiple congenital abnormalities, characterize the structural chromosome rearrangement, and report an unexpected additional imbalance to the inherited rearrangement.. Methods: DNA microarray was used to screen for genomic imbalance in subtelomeric and interstitial critical regions.. High-resolution comparative genomic hybridization was used to screen for genomic imbalance at a genomewide level.

Article Title: Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse.
Article Snippet: First-generation microarray (Human BAC Array-3 Mb system, Spectral Genomics Inc.) comprising 1003 non-overlapping BAC/PAC clones with an average 3 Mb resolution (Human BAC Array 2–4 Mb system, Spectral Genomics Inc.).

Article Title: Genotype-phenotype correlations to aid in the prognosis of individuals with uncommon 20q13.33 subtelomere deletions: a collaborative study on behalf of the 'association des Cytogénéticiens de langue Française'.
Article Snippet: Array CGH analysis was performed in patient 2 using 1 Mb resolution human bacterial artificial chromosome (BAC) microarray, accord- ing to the manufacturer’s recommendations (Spectral Genomics, Inc., Houston, TX, USA).

Microarray:

Article Title: High-resolution detection of recurrent aberrations in lung adenocarcinomas by array comparative genomic hybridization and expression analysis of selective genes by quantitative PCR.
Article Snippet: .. The DNA microarray contained 2621 non-overlapping BAC and PAC clones in duplicates that spanned the entire genome at an average density of 1 Mb per clone (Human BAC Arrays; Spectral Genomics, Inc., Houston, TX, USA). .. Clone information was provided by the chip manufacturer and clone position was mapped according to the National Center for Biotechnology Information MapViewer database, build 37.2.

BAC Assay:

Article Title: High-resolution detection of recurrent aberrations in lung adenocarcinomas by array comparative genomic hybridization and expression analysis of selective genes by quantitative PCR.
Article Snippet: .. The DNA microarray contained 2621 non-overlapping BAC and PAC clones in duplicates that spanned the entire genome at an average density of 1 Mb per clone (Human BAC Arrays; Spectral Genomics, Inc., Houston, TX, USA). .. Clone information was provided by the chip manufacturer and clone position was mapped according to the National Center for Biotechnology Information MapViewer database, build 37.2.

Article Title: Genetic testing for developmental delay: keep searching for an answer.
Article Snippet: .. This whole-genome array of 2600 bacterial artificial chromosome (BAC) clones (Spectral Genomics, Inc.) spaced 1 Mb apart showed a gain in copy number of BAC clones extending from clone RP11–1K11 at 8p23.2 (chr8: 4 596 114 – 4 755 793; human genome build 18) to clone RP11–23H1 at 8p22 (chr8: 15 027 287–15 191 603; hg18) indicative of an approximately 10.6-Mb duplication at 8p22p23.2. ..

Clone Assay:

Article Title: High-resolution detection of recurrent aberrations in lung adenocarcinomas by array comparative genomic hybridization and expression analysis of selective genes by quantitative PCR.
Article Snippet: .. The DNA microarray contained 2621 non-overlapping BAC and PAC clones in duplicates that spanned the entire genome at an average density of 1 Mb per clone (Human BAC Arrays; Spectral Genomics, Inc., Houston, TX, USA). .. Clone information was provided by the chip manufacturer and clone position was mapped according to the National Center for Biotechnology Information MapViewer database, build 37.2.

Article Title: Genetic testing for developmental delay: keep searching for an answer.
Article Snippet: .. This whole-genome array of 2600 bacterial artificial chromosome (BAC) clones (Spectral Genomics, Inc.) spaced 1 Mb apart showed a gain in copy number of BAC clones extending from clone RP11–1K11 at 8p23.2 (chr8: 4 596 114 – 4 755 793; human genome build 18) to clone RP11–23H1 at 8p22 (chr8: 15 027 287–15 191 603; hg18) indicative of an approximately 10.6-Mb duplication at 8p22p23.2. ..



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Image Search Results


CGH using the chromosome 7 (Ch7) BAC tile-path array, Agilent 244A oligonucleotide array platform and chromosome 7 gene resolution oligonucleotide array maps the MDR to a 2.8 Mb region at 7q32 (Panel A). As shown by Affymetrix gene expression analyses, the genes on 7q, particularly those within the MDR are significantly under-expressed in SMZL with 7q deletion than those without the deletion. Panel B shows the genes significantly differentially expressed between SMZL with and without 7q deletion according to P values, while Panel C displays those with further fold change more than 1.25×SD (standard deviation).

Journal: PLoS ONE

Article Title: An Integrated Genomic and Expression Analysis of 7q Deletion in Splenic Marginal Zone Lymphoma

doi: 10.1371/journal.pone.0044997

Figure Lengend Snippet: CGH using the chromosome 7 (Ch7) BAC tile-path array, Agilent 244A oligonucleotide array platform and chromosome 7 gene resolution oligonucleotide array maps the MDR to a 2.8 Mb region at 7q32 (Panel A). As shown by Affymetrix gene expression analyses, the genes on 7q, particularly those within the MDR are significantly under-expressed in SMZL with 7q deletion than those without the deletion. Panel B shows the genes significantly differentially expressed between SMZL with and without 7q deletion according to P values, while Panel C displays those with further fold change more than 1.25×SD (standard deviation).

Article Snippet: summarised the 7q deletion in SMZL detected by CGH using a chromosome-7 BAC tile-path array (17 cases) and the Agilent aCGH 244A array CGH (10 cases) from our previous studies , .

Techniques: Expressing, Standard Deviation

Clinical cycle of comprehensive preimplantation genetic testing. The process starts with family genetic testing in order to establish normal and disease-associated family haplotypes. Next, oocyte stimulation, retrieval, and fertilization are performed. Embryos surviving until day 5 undergo laser-assisted hatching and biopsy. Biopsy material consisting of a few trophectoderm cells is amplified using one of the WGA techniques. WGA material is further used to assess the embryonic genome, including haplotype, causative variant, aneuploidy, and CNV analyses. The disease-free embryo is subjected to embryo transfer to the uterine cavity. The whole cycle can be repeated within 24 h, with a day-6 embryo being transferred. If the genetic testing takes longer, then embryos are vitrified and thawed before being transferred. PGT—preimplantation genetic testing, WGA—whole-genome amplification, IVF—in vitro fertilization, MPS—massively parallel sequencing, CNV—copy number variation.

Journal: International Journal of Molecular Sciences

Article Title: Whole Genome Amplification in Preimplantation Genetic Testing in the Era of Massively Parallel Sequencing

doi: 10.3390/ijms23094819

Figure Lengend Snippet: Clinical cycle of comprehensive preimplantation genetic testing. The process starts with family genetic testing in order to establish normal and disease-associated family haplotypes. Next, oocyte stimulation, retrieval, and fertilization are performed. Embryos surviving until day 5 undergo laser-assisted hatching and biopsy. Biopsy material consisting of a few trophectoderm cells is amplified using one of the WGA techniques. WGA material is further used to assess the embryonic genome, including haplotype, causative variant, aneuploidy, and CNV analyses. The disease-free embryo is subjected to embryo transfer to the uterine cavity. The whole cycle can be repeated within 24 h, with a day-6 embryo being transferred. If the genetic testing takes longer, then embryos are vitrified and thawed before being transferred. PGT—preimplantation genetic testing, WGA—whole-genome amplification, IVF—in vitro fertilization, MPS—massively parallel sequencing, CNV—copy number variation.

Article Snippet: PGT performed on trophectoderm biopsies using PicoPLEX in combination with BlueGnome’s BAC arrays (later Illumina, now discontinued) and subsequently MPS began a major revolution in the availability of human PGT and forever changed the face of clinical in vitro fertilization [ , , ].

Techniques: Amplification, Variant Assay, Whole Genome Amplification, In Vitro, Sequencing