axitinib (Tocris)

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Tocris axitinib
Axitinib, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/axitinib/Axitinib/pmc05934775-252-29-30
Average 93 stars, based on 15 article reviews

axitinib - by Bioz Stars, 2026-10

93/100 stars

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Blocking Assay:

Article Title: Interleukin-6 (IL-6) mediates protection against glucose toxicity in human Müller cells via activation of VEGF-A signaling.
Article Snippet: Interleukin-6 (IL-6) has become a target of interest for drug development aiming to treat diabetic retinopathy.. Since IL-6 signaling can promote beneficial as well as detrimental effects via two different signaling pathways, the objective of the present study was to investigate the effects of classical IL-6 and IL-6 trans-signaling on human Müller cells (HMC), which are important for the development of diabetic retinopathy.. HMCs were cultured in normal (5mmol/L) and high (25mmol/L) glucose plus or minus IL-6 or IL-6/sIL-6R.

Article Title: Systemic vasoprotection by inhaled carbon monoxide is mediated through prolonged alterations in monocyte/macrophage function.
Article Snippet: In functional assays, CM was diluted with EBM-2 (3:2 ratio; Lonza) and added to HUVECs. .. VEGF inhibitor (Axitinib, 20nmol/L; Tocris, Bristol, UK), iNOS inhibitor (L-NAME, 100μmol/L; Sigma, St. Louis, MO, USA), anti-HMGB1 blocking antibody (20μg/mL; 2g7, gift from Dr. K. Tracey) 22 , or nonspecific IgG (Santa Cruz; Dallas, TX, USA) was added to HUVECs. ..

other:

Article Title: The Potential of Transforming Growth Factor-beta Inhibitor and Vascular Endothelial Growth Factor Inhibitor as Therapeutic Agents for Uterine Leiomyoma.
Article Snippet: Ulipristal acetate (UPA) (100 nM; HRA Pharma, Paris, France), mifepristone (RU486; Sigma-Aldrich, St. Louis, MO, USA), LY364947 (inhibitor of TGF-β; Cat. #2718, Tocris Co., Ellisville, MO, USA), and axitinib (inhibitor of VEGF; Cat. #4350, Tocris Co.) were used to treat the cells for 48 h.

Colorimetric Assay:

Article Title: Role of PARP and TRPM2 in VEGF Inhibitor‐Induced Vascular Dysfunction
Article Snippet: .. PARP- 1 onto immobilized histones in human VSMCs exposed to axitinib in presence and absence of pharmacological inhibitors by a colorimetric assay according to the manufacturer’s protocol (4677- 096- K, R&D Systems). ..

Control:

Article Title: Interactions between cadherin-11 and platelet-derived growth factor receptor-alpha signaling link cell adhesion and proliferation
Article Snippet: These reagents were commercially purchased: R&D Systems -Proteome Profiler Human Phospho-RTK Array (proteins assayed listed in Suppl. .. Table 2 ), ELISAs (total and phospho-PDGFRs, IL-6, pro-MMP-1, MMP-3), human cytokine and growth factors (PDGF-AA, PDGF-BB, PDGF-DD, tumor necrosis factor (TNF)-α); Sigma-Aldrich –human IgG 1 isotype control, anti-β-actin antibody (AC-15); Thermo Fisher Scientific -alamarBlue®, Dharmafect3; Tocris–axitinib; EMD Millipore – {"type":"entrez-nucleotide","attrs":{"text":"U01261","term_id":"403513","term_text":"U01261"}} U01261 , SP600125, SB203580, LY294002, SC-514; Cell Signaling -antibodies against phosphorylated (p)Akt (9271), Akt (9272), pJNK (4668), JNK (9252), pERK1/2 (4370), ERK1/2 (4695), p-p38 kinase (4115); Santa Cruz Biotechnologies -antibodies against PDGFRα (C-20) and PDGFRβ (11H4). .. Human cad11Fc and EcadFc was purified from the culture media of stable HEK293 transfectants as previously described [ 13 , 37 ] by protein G columns (BioXCell).

Article Title: Lipid droplet synthesis is associated with angiogenesis in mouse ovarian follicles†.
Article Snippet: Lipid droplets (LDs) are endoplasmic reticulum (ER)-derived organelles comprising a core of neutral lipids surrounded by a phospholipid monolayer.. Lipid droplets play important roles in lipid metabolism and energy homeostasis.. Mammalian ovaries have been hypothesized to use neutral lipids stored in LDs to produce the hormones and nutrients necessary for rapid follicular development; however, our understanding of LD synthesis remains incomplete.

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