automated patch-clamp platform qpatch (Sophion Bioscience)
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Automated Patch Clamp Platform Qpatch, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/automated+patch-clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pm34971874-431-7-10
Average 90 stars, based on 1 article reviews
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Blocking Assay:Article Title: Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K Ca 3.1. Article Snippet: .. 1,4- dihydropyridines were screened for block of KCa3.1 and other channels by patch- clamp using a Patch Clamp:Article Title: Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K Ca 3.1. Article Snippet: .. 1,4- dihydropyridines were screened for block of KCa3.1 and other channels by patch- clamp using a Article Title: Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activity Article Snippet: After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded. .. After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated other:Article Title: Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors. Article Snippet: Ubiquitin-specific protease 1 (USP1), a well-known member of the deubiquitinating enzymes, serves as a key regulator in DNA damage repair (DDR) processes.. Herein, we utilized ringopening and cyclization strategies based on KSQ-4279 to design a novel series of USP1 inhibitors featuring a morpholine scaffold.. Notably, compound 38-P2 exhibited a more potent enzymatic and cellular inhibition activity compared to KSQ-4279. Article Title: Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus Article Snippet: Qube voltage-clamp experiments were performed using human embryonic kidney (HEK) 293 cell lines or Chinese Hamster Ovary cell lines stably expressing either human Na v 1.1, Na v 1.2, Na v 1.3, Na v 1.4, Na v 1.5, Na v 1.6, Na v 1.7, Na v 1.8, or Na v 1.9 on the Qube or Article Title: Targeting GABAergic Hypofunction Associated with Schizophrenia: Identification of α1β2γ2GABA-A Receptor Ligands with Neuroprotective and Antipsychotic Properties. Article Snippet: Electrophysiological experiments were conducted using the Article Title: A hydrophobic loop of the spider-venom peptide Tl1a drives activity at Na V 1.8. Article Snippet: 13 Voltage-gated sodium (NaVs) channels are pore-forming transmembrane proteins that regulate the 14 influx of sodium ions across cell membranes.. Spider venoms are a rich source of NaV-modulating 15 peptides with high selectivity and potency, making them important tools for understanding NaV 16 structure and function.. NaV1.8 is tetrodotoxin-resistant, expressed in the peripheral nervous 17 system and contributes to the propagation of action potentials in nociceptive neurons, making it a 18 potential therapeutic target for pain. Article Title: Conformational restriction enables discovering a series of chroman derivatives as potent and selective Na V 1.8 inhibitors with improved pharmacokinetic properties. Article Snippet: Voltage-gated sodium channel 1.8 (NaV1.8) is a promising analgesic target due to its unique biophysical characteristics and specific role in nociceptive sensation.. VX-150 initially completed proof-of-concept studies in clinical trials, but with high dosages and frequent administration.. Herein, based on VX-150, we report the design, synthesis and structure-activity relationship (SAR) study aiming to identify novel, potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties. Article Title: Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators Article Snippet: Ottiliavej 9, 2500 Valby, Denmark 3 BioEM laboratory, Biozentrum, University of Basel, Basel, Switzerland Corresponding author: Wassim Abdul Rahman Email: wassimabdulrahmanresearch@gmail.com This PDF file includes: Extended methods Figures S1 to S9 Table S1 Extended Methods Kv3.1b electrophysiology using automated patch clamp (QPatch) Patch-clamp recordings were performed using the automated Membrane:Article Title: Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activity Article Snippet: After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded. .. After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated |
