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Sophion Bioscience automated patch-clamp platform qpatch
Automated Patch Clamp Platform Qpatch, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/automated+patch-clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pm34971874-431-7-10
Average 90 stars, based on 1 article reviews
automated patch-clamp platform qpatch - by Bioz Stars, 2026-09
90/100 stars

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Related Articles

Blocking Assay:

Article Title: Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K Ca 3.1.
Article Snippet: .. 1,4- dihydropyridines were screened for block of KCa3.1 and other channels by patch- clamp using a QPatch HTX automated electrophysiology platform (Sophion, Denmark) and by manual patch- clamp. ..

Patch Clamp:

Article Title: Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K Ca 3.1.
Article Snippet: .. 1,4- dihydropyridines were screened for block of KCa3.1 and other channels by patch- clamp using a QPatch HTX automated electrophysiology platform (Sophion, Denmark) and by manual patch- clamp. ..

Article Title: Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activity
Article Snippet: After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded. .. After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded. .. From the recording IKr, an absolute value of the tail peak current was measured based on the current value at the resting membrane potential using analysis software (Falster Patch; Sophion Bioscience A/S).

other:

Article Title: Discovery and Optimization of a Series of Novel Morpholine-Containing USP1 Inhibitors.
Article Snippet: Ubiquitin-specific protease 1 (USP1), a well-known member of the deubiquitinating enzymes, serves as a key regulator in DNA damage repair (DDR) processes.. Herein, we utilized ringopening and cyclization strategies based on KSQ-4279 to design a novel series of USP1 inhibitors featuring a morpholine scaffold.. Notably, compound 38-P2 exhibited a more potent enzymatic and cellular inhibition activity compared to KSQ-4279.

Article Title: Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus
Article Snippet: Qube voltage-clamp experiments were performed using human embryonic kidney (HEK) 293 cell lines or Chinese Hamster Ovary cell lines stably expressing either human Na v 1.1, Na v 1.2, Na v 1.3, Na v 1.4, Na v 1.5, Na v 1.6, Na v 1.7, Na v 1.8, or Na v 1.9 on the Qube or Qpatch automated patch-clamp platforms (Sophion Bioscience A/S, Ballerup, Denmark).

Article Title: Targeting GABAergic Hypofunction Associated with Schizophrenia: Identification of α1β2γ2GABA-A Receptor Ligands with Neuroprotective and Antipsychotic Properties.
Article Snippet: Electrophysiological experiments were conducted using the QPatch16X automated patch-clamp platform (Sophion Bioscience).

Article Title: A hydrophobic loop of the spider-venom peptide Tl1a drives activity at Na V 1.8.
Article Snippet: 13 Voltage-gated sodium (NaVs) channels are pore-forming transmembrane proteins that regulate the 14 influx of sodium ions across cell membranes.. Spider venoms are a rich source of NaV-modulating 15 peptides with high selectivity and potency, making them important tools for understanding NaV 16 structure and function.. NaV1.8 is tetrodotoxin-resistant, expressed in the peripheral nervous 17 system and contributes to the propagation of action potentials in nociceptive neurons, making it a 18 potential therapeutic target for pain.

Article Title: Conformational restriction enables discovering a series of chroman derivatives as potent and selective Na V 1.8 inhibitors with improved pharmacokinetic properties.
Article Snippet: Voltage-gated sodium channel 1.8 (NaV1.8) is a promising analgesic target due to its unique biophysical characteristics and specific role in nociceptive sensation.. VX-150 initially completed proof-of-concept studies in clinical trials, but with high dosages and frequent administration.. Herein, based on VX-150, we report the design, synthesis and structure-activity relationship (SAR) study aiming to identify novel, potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties.

Article Title: Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators
Article Snippet: Ottiliavej 9, 2500 Valby, Denmark 3 BioEM laboratory, Biozentrum, University of Basel, Basel, Switzerland Corresponding author: Wassim Abdul Rahman Email: wassimabdulrahmanresearch@gmail.com This PDF file includes: Extended methods Figures S1 to S9 Table S1 Extended Methods Kv3.1b electrophysiology using automated patch clamp (QPatch) Patch-clamp recordings were performed using the automated recording system QPatch16x/QPatchII-48x (Sophion Bioscience, Denmark).

Membrane:

Article Title: Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activity
Article Snippet: After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded. .. After a cell was retained at a membrane potential of −80 mV by whole cell patch clamp method using an automated patch clamp system (QPatch; Sophion BIoscience A/S), IKr induced by application of a leak potential of −50 mV followed by depolarization pulse stimulation at +20 mV for 2 seconds and, further, repolarization pulse stimulation at −50 mV for 2 seconds, was recorded. .. From the recording IKr, an absolute value of the tail peak current was measured based on the current value at the resting membrane potential using analysis software (Falster Patch; Sophion Bioscience A/S).



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Sophion Bioscience qpatch automated patch-clamp platform
Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
Qpatch Automated Patch Clamp Platform, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Sophion Bioscience automated patch clamp platform qpatch
Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
Automated Patch Clamp Platform Qpatch, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
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Sophion Bioscience automated patch-clamp platform qpatch
Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
Automated Patch Clamp Platform Qpatch, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/automated+patch-clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pm34971874-431-7-10
Average 90 stars, based on 1 article reviews
automated patch-clamp platform qpatch - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
Sophion Bioscience qpatch automated patch clamp platform
Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
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Average 90 stars, based on 1 article reviews
qpatch automated patch clamp platform - by Bioz Stars, 2026-09
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Sophion Bioscience automated patch-clamp platform qpatch 16
Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
Automated Patch Clamp Platform Qpatch 16, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/automated+patch-clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pm28322838-46-7-11
Average 90 stars, based on 1 article reviews
automated patch-clamp platform qpatch 16 - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

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Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

Journal: Pain

Article Title: Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus

doi: 10.1097/j.pain.0000000000003404

Figure Lengend Snippet: Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

Article Snippet: Qube voltage-clamp experiments were performed using human embryonic kidney (HEK) 293 cell lines or Chinese Hamster Ovary cell lines stably expressing either human Na v 1.1, Na v 1.2, Na v 1.3, Na v 1.4, Na v 1.5, Na v 1.6, Na v 1.7, Na v 1.8, or Na v 1.9 on the Qube or Qpatch automated patch-clamp platforms (Sophion Bioscience A/S, Ballerup, Denmark).

Techniques: Patch Clamp