qpatch (Sophion Bioscience)
86
Structured Review
Sophion Bioscience
qpatch
Qpatch, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch/us12617791-475-6-7
Average 86 stars, based on 1 article reviews
Qpatch, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch/us12617791-475-6-7
Average 86 stars, based on 1 article reviews
qpatch - by Bioz Stars,
2026-11
86/100 stars
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Stable Transfection:Article Title: Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors Article Snippet: .. CHO cells stably expressing the transcript of hERG were investigated by the automated whole-cell patch clamp technique, using the Article Title: Design, Synthesis, and Biological Evaluation of 2-Substituted Aniline Pyrimidine Derivatives as Potent Dual Mer/c-Met Inhibitors. Article Snippet: The IC50 for compound 18c was calculated with the program GraphPad PRISM 9.5. .. CHO cells stably expressing the transcript of hERG were investigated by the automated whole-cell patch clamp technique, using the Article Title: Design, synthesis, and biological evaluation of novel 2-substituted aniline pyrimidine derivatives as potential and orally bioavailable Mer inhibitors with antitumor activities. Article Snippet: The constitutive overexpression of Mer tyrosine kinase (MerTK), strongly associated with tumorigenesis and progression across multiple malignancies, establishes it as a promising therapeutic target for oncology discovery.. In this study, we systematically designed and synthesized a series of 2-substituted aniline pyrimidine derivatives as potent MerTK inhibitors.. The lead compound 15f demonstrated excellent inhibitory activity against Mer kinase with an IC50 value of 37.5 ± 2.7 nM, coupled with broad-spectrum antiproliferative activities against A2780, MDA-MB-231, and HCT116 cancer cell lines. Expressing:Article Title: Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors Article Snippet: .. CHO cells stably expressing the transcript of hERG were investigated by the automated whole-cell patch clamp technique, using the Article Title: Design, Synthesis, and Biological Evaluation of 2-Substituted Aniline Pyrimidine Derivatives as Potent Dual Mer/c-Met Inhibitors. Article Snippet: The IC50 for compound 18c was calculated with the program GraphPad PRISM 9.5. .. CHO cells stably expressing the transcript of hERG were investigated by the automated whole-cell patch clamp technique, using the Article Title: Design, synthesis, and biological evaluation of novel 2-substituted aniline pyrimidine derivatives as potential and orally bioavailable Mer inhibitors with antitumor activities. Article Snippet: The constitutive overexpression of Mer tyrosine kinase (MerTK), strongly associated with tumorigenesis and progression across multiple malignancies, establishes it as a promising therapeutic target for oncology discovery.. In this study, we systematically designed and synthesized a series of 2-substituted aniline pyrimidine derivatives as potent MerTK inhibitors.. The lead compound 15f demonstrated excellent inhibitory activity against Mer kinase with an IC50 value of 37.5 ± 2.7 nM, coupled with broad-spectrum antiproliferative activities against A2780, MDA-MB-231, and HCT116 cancer cell lines. Patch Clamp:Article Title: Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors Article Snippet: .. CHO cells stably expressing the transcript of hERG were investigated by the automated whole-cell patch clamp technique, using the Article Title: Design, Synthesis, and Biological Evaluation of 2-Substituted Aniline Pyrimidine Derivatives as Potent Dual Mer/c-Met Inhibitors. Article Snippet: The IC50 for compound 18c was calculated with the program GraphPad PRISM 9.5. .. CHO cells stably expressing the transcript of hERG were investigated by the automated whole-cell patch clamp technique, using the Article Title: Design, synthesis, and biological evaluation of novel 2-substituted aniline pyrimidine derivatives as potential and orally bioavailable Mer inhibitors with antitumor activities. Article Snippet: The constitutive overexpression of Mer tyrosine kinase (MerTK), strongly associated with tumorigenesis and progression across multiple malignancies, establishes it as a promising therapeutic target for oncology discovery.. In this study, we systematically designed and synthesized a series of 2-substituted aniline pyrimidine derivatives as potent MerTK inhibitors.. The lead compound 15f demonstrated excellent inhibitory activity against Mer kinase with an IC50 value of 37.5 ± 2.7 nM, coupled with broad-spectrum antiproliferative activities against A2780, MDA-MB-231, and HCT116 cancer cell lines. Article Title: Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons Article Snippet: .. [ , ] To overcome these shortcomings, planar patch clamp, as an alternative, was developed, and is now commercially available through products such as Syncropatch 384 by Nanion Technologies, other:Article Title: Triheterocyclic derivative, and pharmaceutical composition and application thereof Article Snippet: Whole-cell recordings were performed using automated Article Title: Nicotinic acetylcholine receptor peptide antagonist conotoxin compositions and related methods Article Snippet: In some embodiments, the automated assay uses a commercially-available platforms, e.g., PatchXpress and IonFlux (Molecular Devices, LLC, Sunnyvale, CA, USA), |
