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qpatch  (Icagen Inc)

 
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    Icagen Inc qpatch
    Qpatch, supplied by Icagen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch/pmc04800267-92-11-4
    Average 90 stars, based on 1 article reviews
    qpatch - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    other:

    Article Title: Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening
    Article Snippet: The Nav1.3 selectivity of Icagen compound 68 was previously determined on QPatch (hNav1.5) and in voltage clamp recordings from mammalian Nav1.x channels expressed in Xenopus oocytes (rNav1.4, mNav1.6, hNav1.7) by ourselves and our MAREX collaborators, with no significant effects on resting or inactivated current amplitudes in any of the Nav1.x isoforms tested.



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    Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Journal: Pain

    Article Title: Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus

    doi: 10.1097/j.pain.0000000000003404

    Figure Lengend Snippet: Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Article Snippet: Qube voltage-clamp experiments were performed using human embryonic kidney (HEK) 293 cell lines or Chinese Hamster Ovary cell lines stably expressing either human Na v 1.1, Na v 1.2, Na v 1.3, Na v 1.4, Na v 1.5, Na v 1.6, Na v 1.7, Na v 1.8, or Na v 1.9 on the Qube or Qpatch automated patch-clamp platforms (Sophion Bioscience A/S, Ballerup, Denmark).

    Techniques: Patch Clamp