Review



qpatch htx  (ICE Bioscience)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    ICE Bioscience qpatch htx
    Chemical structure, THR- β activity, and PK properties of CS27109: (a) chemical structure of several oral and liver-targeted THR- β agonists, including KB-141, VK2809, MGL3196, and CS27109, (b) THR- α and THR- β activity for each compound were determined by a luciferase reporter gene assay, (c) hERG test of CS27109 was conducted by the <t>QPatch</t> <t>HTX,</t> (d) mouse, and (e) rat PK studies for CS27109 and MGL3196.
    Qpatch Htx, supplied by ICE Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch+htx/pmc09943626-78-13-5
    Average 90 stars, based on 1 article reviews
    qpatch htx - by Bioz Stars, 2026-11
    90/100 stars

    Images

    1) Product Images from "CS27109, A Selective Thyroid Hormone Receptor- β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models"

    Article Title: CS27109, A Selective Thyroid Hormone Receptor- β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

    Journal: International Journal of Endocrinology

    doi: 10.1155/2023/4950597

    Chemical structure, THR- β activity, and PK properties of CS27109: (a) chemical structure of several oral and liver-targeted THR- β agonists, including KB-141, VK2809, MGL3196, and CS27109, (b) THR- α and THR- β activity for each compound were determined by a luciferase reporter gene assay, (c) hERG test of CS27109 was conducted by the QPatch HTX, (d) mouse, and (e) rat PK studies for CS27109 and MGL3196.
    Figure Legend Snippet: Chemical structure, THR- β activity, and PK properties of CS27109: (a) chemical structure of several oral and liver-targeted THR- β agonists, including KB-141, VK2809, MGL3196, and CS27109, (b) THR- α and THR- β activity for each compound were determined by a luciferase reporter gene assay, (c) hERG test of CS27109 was conducted by the QPatch HTX, (d) mouse, and (e) rat PK studies for CS27109 and MGL3196.

    Techniques Used: Activity Assay, Luciferase, Reporter Gene Assay

    Related Articles

    Activity Assay:

    Article Title: CS27109, A Selective Thyroid Hormone Receptor- β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models
    Article Snippet: hERG test was performed by Ice Bioscience Co., Ltd. (Beijing, China) using the QPatch HTX method according to the manufacturer's instruction. .. 5

    Luciferase:

    Article Title: CS27109, A Selective Thyroid Hormone Receptor- β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models
    Article Snippet: hERG test was performed by Ice Bioscience Co., Ltd. (Beijing, China) using the QPatch HTX method according to the manufacturer's instruction. .. 5

    Reporter Gene Assay:

    Article Title: CS27109, A Selective Thyroid Hormone Receptor- β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models
    Article Snippet: hERG test was performed by Ice Bioscience Co., Ltd. (Beijing, China) using the QPatch HTX method according to the manufacturer's instruction. .. 5



    Similar Products

    qpatch automated patch-clamp platform  (Sophion Bioscience)
    90
    Sophion Bioscience qpatch automated patch-clamp platform
    Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
    Qpatch Automated Patch Clamp Platform, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pmc11808707-32-55-59
    Average 90 stars, based on 1 article reviews
    qpatch automated patch-clamp platform - by Bioz Stars, 2026-11
    90/100 stars
    		  Buy from Supplier
    automated patch clamp platform qpatch  (Sophion Bioscience)
    90
    Sophion Bioscience automated patch clamp platform qpatch
    Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
    Automated Patch Clamp Platform Qpatch, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/us11944623-637-7-11
    Average 90 stars, based on 1 article reviews
    automated patch clamp platform qpatch - by Bioz Stars, 2026-11
    90/100 stars
    		  Buy from Supplier
    qpatch-16 automated patch-clamp electrophysiology platform  (Sophion Bioscience)
    90
    Sophion Bioscience qpatch-16 automated patch-clamp electrophysiology platform
    Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
    Qpatch 16 Automated Patch Clamp Electrophysiology Platform, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pm37262436-184-6-11
    Average 90 stars, based on 1 article reviews
    qpatch-16 automated patch-clamp electrophysiology platform - by Bioz Stars, 2026-11
    90/100 stars
    		  Buy from Supplier
    automated patch-clamp platform qpatch  (Sophion Bioscience)
    90
    Sophion Bioscience automated patch-clamp platform qpatch
    Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
    Automated Patch Clamp Platform Qpatch, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pm34971874-431-7-10
    Average 90 stars, based on 1 article reviews
    automated patch-clamp platform qpatch - by Bioz Stars, 2026-11
    90/100 stars
    		  Buy from Supplier
    qpatch automated patch clamp platform  (Sophion Bioscience)
    90
    Sophion Bioscience qpatch automated patch clamp platform
    Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
    Qpatch Automated Patch Clamp Platform, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pm30999054-54-8-13
    Average 90 stars, based on 1 article reviews
    qpatch automated patch clamp platform - by Bioz Stars, 2026-11
    90/100 stars
    		  Buy from Supplier
    automated patch-clamp platform qpatch 16  (Sophion Bioscience)
    90
    Sophion Bioscience automated patch-clamp platform qpatch 16
    Na v channel compound profile assessed on the Qube or <t>Qpatch*.</t> Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.
    Automated Patch Clamp Platform Qpatch 16, supplied by Sophion Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/automated+patch+clamp+platform+qpatch/qpatch+16+automated+electrophysiology+platform/pm28322838-46-7-11
    Average 90 stars, based on 1 article reviews
    automated patch-clamp platform qpatch 16 - by Bioz Stars, 2026-11
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Journal: Pain

    Article Title: Analgesia and peripheral c-fiber modulation by selective Na v 1.8 inhibition in rhesus

    doi: 10.1097/j.pain.0000000000003404

    Figure Lengend Snippet: Na v channel compound profile assessed on the Qube or Qpatch*. Ten-point titrations in the Qube automated patch-clamp assay determined MSD199 to be a potent and selective compound (IC 50 = 4.7 ± 0.8 nM, mean ± SD). MSD199 potency was too weak to calculate for all other Na v isoforms except Na v 1.4, which was 1781-fold shifted to 8370 nM mean IC 50 ± 1429.

    Article Snippet: Qube voltage-clamp experiments were performed using human embryonic kidney (HEK) 293 cell lines or Chinese Hamster Ovary cell lines stably expressing either human Na v 1.1, Na v 1.2, Na v 1.3, Na v 1.4, Na v 1.5, Na v 1.6, Na v 1.7, Na v 1.8, or Na v 1.9 on the Qube or Qpatch automated patch-clamp platforms (Sophion Bioscience A/S, Ballerup, Denmark).

    Techniques: Patch Clamp