arpe 19 cells (Procell Inc)
86
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Procell Inc
arpe 19 cells
Arpe 19 Cells, supplied by Procell Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/arp/19+arpe+cells/pm42285191-96-0-2
Average 86 stars, based on 1 article reviews
Arpe 19 Cells, supplied by Procell Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/arp/19+arpe+cells/pm42285191-96-0-2
Average 86 stars, based on 1 article reviews
arpe 19 cells - by Bioz Stars,
2026-11
86/100 stars
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other:Article Title: ROS-responsive transmembrane peptide-antibody conjugate eyedrops for the non-invasive treatment of choroidoretinopathy Article Snippet: Anti-mouse PDL-1 and anti-mouse VEGFA were purchased from ABclonal Biotechnology Co., Ltd. (Wuhan, China), and anti-human VEGFA was purchased from Novartis Pharmaceuticals (Beijing, China). Cell Culture:Article Title: Intra-mitochondrial glycolysis maintains mitochondrial function and underlies the pathogenesis of retinitis pigmentosa. Article Snippet: .. ARPE-19 cells and primary mouse retinal pigment epithelial cells were cultured in either DMEM F12 or DMEM high glucose medium (HyClone), while 293T cells were maintained in 1640 medium (HyClone), while primary Article Title: The role of TRAF6 in regulating MAP3K7/P38/MAPK pathway in the epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy. Article Snippet: Proliferative vitreoretinopathy (PVR) is a major cause of blindness.. Surgery remains the primary clinical intervention, but its outcomes are frequently unsatisfactory.. A deeper understanding of PVR pathophysiology is therefore essential for developing new treatments. Article Title: SREBP1-driven SCD1 protects retinal pigment epithelium from oxidative damage by activating the NRF2/GPX4 axis. Article Snippet: This study reveals the pivotal role of the Sterol Regulatory Element-Binding Protein 1 (SREBP1)/Stearoyl-CoA Desaturase 1 (SCD1) lipid metabolic axis in protecting retinal pigment epithelium (RPE) against oxidative damage.. We demonstrate SCD1 downregulation in age-related macular degeneration (AMD) patient tissues and sodium iodate (SI)-induced models, while its overexpression enhances cell viability and ameliorates oxidative injury.. Mechanistically, we uncover a novel pathway where SCD1-derived oleic acid activates the nuclear factor erythroid 2-related factor 2 (NRF2)/glutathione peroxidase 4 (GPX4) signaling cascade, scavenging reactive oxygen species (ROS) and suppressing lipid peroxidation. Virus:Article Title: Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration. Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Anti-histone H3 (acetyl K27) antibody Abcam Cat# ab4729; RRID: AB_2118291 Bacterial and virus strains MegaX DH10B T1R electrocompetent cells Thermo Fischer Scientific Cat# C640003 Biological samples Frozen adult postmortem human retinal pigment epithelium and choroid Lions VisionGift, Lions Gift of Sight N/A Chemicals, peptides, and recombinant proteins IGEPAL CA-630 Sigma-Aldrich Cat# I8896 RNase inhibitor New England BioLabs Cat# M0314 Protease inhibitor Roche Cat# 11697498001 Iodixanol Sigma-Aldrich Cat# D1556 Tween 20 Roche Cat# 11332465001 Bovine serum albumin Miltenyi Biotec Cat# 130-091-376 Digitonin Thermo Fischer Scientific Cat# BN2006 Glycerol Ricca Chemical Cat# 3290-16 Paraformaldehyde Electron Microscopy Sciences Cat# 50-980-487 Sodium dodecyl sulfate Invitrogen Cat# 15553027 Triton X-100 Sigma-Aldrich Cat# 93443 MboI New England BioLabs Cat# R0147 Biotin-14-dATP Jena Bioscience Cat# NU-835-BIO14 Klenow fragment New England BioLabs Cat# M0210 T4 DNA ligase New England BioLabs Cat# M0202 Dimethylformamide Sigma-Aldrich Cat# 227056 Sodium deoxycholate Bioworld Cat# 40430018 Normal human serum EMD Millipore Cat# S1-LITER Lipofectamine 3000 Invitrogen Cat# L3000001 Critical commercial assays Single Cell Multiome ATAC + Gene Expression kit 10× Genomics Cat# 1000285 KAPA HiFi HotStart ReadyMix Roche Cat# KK2601 M5 HiPer Universal RNA Mini Kit Mei5bio Cat# MF036-01 SuperScript III First-Strand Synthesis System Invitrogen Cat# 18080051 Dual-Luciferase Reporter 1000 Assay System Promega Cat# E1910 Deposited data scRNA-seq, scATAC-seq, and HiChIP data This paper GEO: GSE262151 STARR-seq data This paper GEO: GSE289703 ChromBPNet models This paper Zenodo: https://doi.org/10.5281/zenodo.14031498 Code for scRNA-seq and scATAC-seq This paper GitHub: https://github.com/seankwang/ RPEchoroid-multiome Experimental models: Recombinant:Article Title: Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration. Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Anti-histone H3 (acetyl K27) antibody Abcam Cat# ab4729; RRID: AB_2118291 Bacterial and virus strains MegaX DH10B T1R electrocompetent cells Thermo Fischer Scientific Cat# C640003 Biological samples Frozen adult postmortem human retinal pigment epithelium and choroid Lions VisionGift, Lions Gift of Sight N/A Chemicals, peptides, and recombinant proteins IGEPAL CA-630 Sigma-Aldrich Cat# I8896 RNase inhibitor New England BioLabs Cat# M0314 Protease inhibitor Roche Cat# 11697498001 Iodixanol Sigma-Aldrich Cat# D1556 Tween 20 Roche Cat# 11332465001 Bovine serum albumin Miltenyi Biotec Cat# 130-091-376 Digitonin Thermo Fischer Scientific Cat# BN2006 Glycerol Ricca Chemical Cat# 3290-16 Paraformaldehyde Electron Microscopy Sciences Cat# 50-980-487 Sodium dodecyl sulfate Invitrogen Cat# 15553027 Triton X-100 Sigma-Aldrich Cat# 93443 MboI New England BioLabs Cat# R0147 Biotin-14-dATP Jena Bioscience Cat# NU-835-BIO14 Klenow fragment New England BioLabs Cat# M0210 T4 DNA ligase New England BioLabs Cat# M0202 Dimethylformamide Sigma-Aldrich Cat# 227056 Sodium deoxycholate Bioworld Cat# 40430018 Normal human serum EMD Millipore Cat# S1-LITER Lipofectamine 3000 Invitrogen Cat# L3000001 Critical commercial assays Single Cell Multiome ATAC + Gene Expression kit 10× Genomics Cat# 1000285 KAPA HiFi HotStart ReadyMix Roche Cat# KK2601 M5 HiPer Universal RNA Mini Kit Mei5bio Cat# MF036-01 SuperScript III First-Strand Synthesis System Invitrogen Cat# 18080051 Dual-Luciferase Reporter 1000 Assay System Promega Cat# E1910 Deposited data scRNA-seq, scATAC-seq, and HiChIP data This paper GEO: GSE262151 STARR-seq data This paper GEO: GSE289703 ChromBPNet models This paper Zenodo: https://doi.org/10.5281/zenodo.14031498 Code for scRNA-seq and scATAC-seq This paper GitHub: https://github.com/seankwang/ RPEchoroid-multiome Experimental models: Modification:Article Title: SREBP1-driven SCD1 protects retinal pigment epithelium from oxidative damage by activating the NRF2/GPX4 axis. Article Snippet: This study reveals the pivotal role of the Sterol Regulatory Element-Binding Protein 1 (SREBP1)/Stearoyl-CoA Desaturase 1 (SCD1) lipid metabolic axis in protecting retinal pigment epithelium (RPE) against oxidative damage.. We demonstrate SCD1 downregulation in age-related macular degeneration (AMD) patient tissues and sodium iodate (SI)-induced models, while its overexpression enhances cell viability and ameliorates oxidative injury.. Mechanistically, we uncover a novel pathway where SCD1-derived oleic acid activates the nuclear factor erythroid 2-related factor 2 (NRF2)/glutathione peroxidase 4 (GPX4) signaling cascade, scavenging reactive oxygen species (ROS) and suppressing lipid peroxidation. |