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teto appswe ind transgene  (Jackson Laboratory)

 
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    Structured Review

    Jackson Laboratory teto appswe ind transgene
    Autophagic activity in the mouse brain was modulated by both aging and mutant APP <t>transgene</t> expression. a Representative western blot images are shown. Autophagy-related targets assessed include ( b ) LC3A-II/LC3A-I ratio, ( c ) total LC3A, ( d ) LC3B-II/LC3B-I ratio, ( e ) total LC3B, ( f ) ATG3, ( g ) ATG5, ( h ) ATG7, ( i ) ATG12, ( j ) Beclin-1, and ( k ) SQSTM1/p62. Sample size was 5 male and 5 female 18mo controls, 4–5 male and 6 female APP 6 → 18mo, 4–5 male and 5 female 24mo controls, and 5 male and 5–6 female APP 12 → 24mo. Individual data points and group means ± S.E.M. are presented. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001
    Teto Appswe Ind Transgene, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/appswe+ind+teto+transgene/pmc12849525-207-4-9
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    teto appswe ind transgene - by Bioz Stars, 2026-10
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    Images

    1) Product Images from "Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression"

    Article Title: Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression

    Journal: Journal of Neuroinflammation

    doi: 10.1186/s12974-025-03682-2

    Autophagic activity in the mouse brain was modulated by both aging and mutant APP transgene expression. a Representative western blot images are shown. Autophagy-related targets assessed include ( b ) LC3A-II/LC3A-I ratio, ( c ) total LC3A, ( d ) LC3B-II/LC3B-I ratio, ( e ) total LC3B, ( f ) ATG3, ( g ) ATG5, ( h ) ATG7, ( i ) ATG12, ( j ) Beclin-1, and ( k ) SQSTM1/p62. Sample size was 5 male and 5 female 18mo controls, 4–5 male and 6 female APP 6 → 18mo, 4–5 male and 5 female 24mo controls, and 5 male and 5–6 female APP 12 → 24mo. Individual data points and group means ± S.E.M. are presented. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001
    Figure Legend Snippet: Autophagic activity in the mouse brain was modulated by both aging and mutant APP transgene expression. a Representative western blot images are shown. Autophagy-related targets assessed include ( b ) LC3A-II/LC3A-I ratio, ( c ) total LC3A, ( d ) LC3B-II/LC3B-I ratio, ( e ) total LC3B, ( f ) ATG3, ( g ) ATG5, ( h ) ATG7, ( i ) ATG12, ( j ) Beclin-1, and ( k ) SQSTM1/p62. Sample size was 5 male and 5 female 18mo controls, 4–5 male and 6 female APP 6 → 18mo, 4–5 male and 5 female 24mo controls, and 5 male and 5–6 female APP 12 → 24mo. Individual data points and group means ± S.E.M. are presented. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001

    Techniques Used: Activity Assay, Mutagenesis, Expressing, Western Blot



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    Image Search Results


    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

    Journal: bioRxiv

    Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

    doi: 10.64898/2026.04.30.721994

    Figure Lengend Snippet: (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

    Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

    Techniques: Expressing

    A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

    Journal: bioRxiv

    Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

    doi: 10.64898/2026.04.30.721994

    Figure Lengend Snippet: A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

    Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

    Techniques: