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model 1349  (Taconic Biosciences)


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    Taconic Biosciences model 1349
    Model 1349, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 93/100, based on 24 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/APPSWE+-+Model+1349/pmc09684486-271-28-30
    Average 93 stars, based on 24 article reviews
    model 1349 - by Bioz Stars, 2026-11
    93/100 stars

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    Related Articles

    In Vivo:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    MANN-WHITNEY:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Activity Assay:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Cell Counting:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Immunostaining:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Immunofluorescence:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Expressing:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Injection:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Fluorescence:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Slice Preparation:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.

    Construct:

    Article Title: Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease
    Article Snippet: Heterozygous male Tg2576 mice (Taconic #APPSWE—Model 1349 tg/wt; [ ]) and their Wild-Type (WT) littermates (mice with the same strain and genetic background of Tg2576, negative for APPSWE overexpression—Taconic #APPSWE—Model 1349 wt/wt) were used at 6–7 months of age.

    Article Title: Treatment of central nervous system disorders by intranasal administration of immunoglobulin G
    Article Snippet: TG2576 mice (cat. #1349-RD1-M) were acquired from Taconic, Inc. in two batches of 50 spaced one month apart (Batch 1 and Batch 2).

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer's disease.
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12-13 months of age were used.

    Article Title: Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer’s disease
    Article Snippet: Heterozygous DATCre IRES female mice (The Jackson Laboratory, Strain #006660) were crossed with heterozygous Tg2576 males (Taconic, APPSWE - Model #1349) to generate DATCre/WT and DATCre/Tg2576 mice that were used at 5–6 months of age.

    Article Title: Microglial clearance, neuroprotection and cognitive recovery via a novel synthetic sulfolipid in Alzheimer’s disease
    Article Snippet: Heterozygous Tg2576 mice (Taconic, APPSWE Model 1349) from 45 day-old to 6 months of age and at 12–13 months of age were used.



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    Jackson Laboratory appswe ps1e9 transgenic app ps1 tg mice
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Appswe Ps1e9 Transgenic App Ps1 Tg Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    appswe ps1deltae9 de9 transgenic mice  (Jackson Laboratory)
    86
    Jackson Laboratory appswe ps1deltae9 de9 transgenic mice
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Appswe Ps1deltae9 De9 Transgenic Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/app+mice+ps1/pm41396874-34-0-38
    Average 86 stars, based on 1 article reviews
    appswe ps1deltae9 de9 transgenic mice - by Bioz Stars, 2026-11
    86/100 stars
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    Image Search Results


    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

    Journal: bioRxiv

    Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

    doi: 10.64898/2026.04.30.721994

    Figure Lengend Snippet: (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

    Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

    Techniques: Expressing

    A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

    Journal: bioRxiv

    Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

    doi: 10.64898/2026.04.30.721994

    Figure Lengend Snippet: A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

    Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

    Techniques: