Review



familial ad mice  (Taconic Biosciences)


Bioz Verified Symbol Taconic Biosciences is a verified supplier  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    Taconic Biosciences familial ad mice
    Familial Ad Mice, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/APPSWE+-+Model+2789/pm36113018-22-5-17
    Average 90 stars, based on 2 article reviews
    familial ad mice - by Bioz Stars, 2026-11
    90/100 stars

    Images

    Related Articles

    Expressing:

    Article Title: P1-225: A study to evaluate the pharmacokinetics and pharmacodynamics of single and multiple oral doses of the novel BACE inhibitor MK-8931 in Japanese subjects
    Article Snippet: + cells.. Results: Estrone significantly decreased the levels of beta-amyloid in the cerebral cortex (P 1⁄4 0.0001) and corpus callosum (P 1⁄4 0.001).. In addition, the TBI rats treated with estrone had reduced cortical lesion volume and cortical levels of TUNEL + staining (w80%).

    Control:

    Article Title: P1-225: A study to evaluate the pharmacokinetics and pharmacodynamics of single and multiple oral doses of the novel BACE inhibitor MK-8931 in Japanese subjects
    Article Snippet: + cells.. Results: Estrone significantly decreased the levels of beta-amyloid in the cerebral cortex (P 1⁄4 0.0001) and corpus callosum (P 1⁄4 0.001).. In addition, the TBI rats treated with estrone had reduced cortical lesion volume and cortical levels of TUNEL + staining (w80%).

    other:

    Article Title: Acetoacetate Improves Memory in Alzheimer’s Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation
    Article Snippet: A total of 48 male familial AD mice (APPSWE - Model 2789) (9-10 months, 25-30g) were purchased from Taconic Biosciences (La Jolla, USA).

    Article Title: Acetoacetate Improves Memory in Alzheimer's Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation.
    Article Snippet: A total of 48 male familial AD mice (APPSWE -Model 2789) (9-10 months, 25-30g) were purchased from Taconic Biosciences (La Jolla, USA).



    Similar Products

    appswe psen1de9  (Huafukang Technology)
    86
    Huafukang Technology appswe psen1de9
    Appswe Psen1de9, supplied by Huafukang Technology, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/6j+c57bl+mice/pm42316357-73-0-14
    Average 86 stars, based on 1 article reviews
    appswe psen1de9 - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    appswe ps1de9 app  (Jackson Laboratory)
    86
    Jackson Laboratory appswe ps1de9 app
    Appswe Ps1de9 App, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/appswe+mice+ps1de9+transgenic/bio_rxiv__64898__2026__05__14__725257-36-0-16
    Average 86 stars, based on 1 article reviews
    appswe ps1de9 app - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    hemizygous appswe ps1de9 app ps1 mice  (Jackson Laboratory)
    86
    Jackson Laboratory hemizygous appswe ps1de9 app ps1 mice
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Hemizygous Appswe Ps1de9 App Ps1 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/appswe+mice+ps1de9+transgenic/bio_rxiv__64898__2026__04__30__721994-203-0-11
    Average 86 stars, based on 1 article reviews
    hemizygous appswe ps1de9 app ps1 mice - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    appswe  (Jackson Laboratory)
    86
    Jackson Laboratory appswe
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Appswe, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/b6+cg+tg/bio_rxiv__64898__2026__03__19__712819-22-1-8
    Average 86 stars, based on 1 article reviews
    appswe - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    appswe psen1de9 transgenic mice  (Jackson Laboratory)
    86
    Jackson Laboratory appswe psen1de9 transgenic mice
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Appswe Psen1de9 Transgenic Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/b6+cg+tg/pm41841574-38-1-9
    Average 86 stars, based on 1 article reviews
    appswe psen1de9 transgenic mice - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    appswe ps1de9 transgenic tg mice  (Jackson Laboratory)
    86
    Jackson Laboratory appswe ps1de9 transgenic tg mice
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Appswe Ps1de9 Transgenic Tg Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/appswe+mice+ps1de9+transgenic/pm41775989-51-7-11
    Average 86 stars, based on 1 article reviews
    appswe ps1de9 transgenic tg mice - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    appswe ps1de9 app ps1 mice  (Jackson Laboratory)
    86
    Jackson Laboratory appswe ps1de9 app ps1 mice
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Appswe Ps1de9 App Ps1 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/appswe+mice+ps1de9+transgenic/pm41736084-46-0-15
    Average 86 stars, based on 1 article reviews
    appswe ps1de9 app ps1 mice - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    appswe ps1e9 transgenic app ps1 tg mice  (Jackson Laboratory)
    86
    Jackson Laboratory appswe ps1e9 transgenic app ps1 tg mice
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Appswe Ps1e9 Transgenic App Ps1 Tg Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/app+mice+ps1/pm41707905-72-1-9
    Average 86 stars, based on 1 article reviews
    appswe ps1e9 transgenic app ps1 tg mice - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier
    appswe ps1deltae9 de9 transgenic mice  (Jackson Laboratory)
    86
    Jackson Laboratory appswe ps1deltae9 de9 transgenic mice
    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = <t>male</t> <t>APP/PS1</t> (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.
    Appswe Ps1deltae9 De9 Transgenic Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/appswe/app+mice+ps1/pm41396874-34-0-38
    Average 86 stars, based on 1 article reviews
    appswe ps1deltae9 de9 transgenic mice - by Bioz Stars, 2026-11
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

    Journal: bioRxiv

    Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

    doi: 10.64898/2026.04.30.721994

    Figure Lengend Snippet: (A) A schematic representing the workflow of the TMT analysis of BMDMs. (B) The total number of circadian proteins (harmonic/damped/forced) in each of the categories, represented in a bar chart. Dark blue/black outline = male littermate (LM), light blue/black outline = male APP/PS1 (AP) mice, red/black outline = male circadianly disrupted (CD), orange/black outline = male CD/AP, dark blue = female littermate (LM), light blue = female AP, red = female CD, orange = female CD/AP. (C) Radial histograms of the number of oscillating proteins that reach their peak phase at a given circadian timepoint (CT). (D) Heatmaps of proteins with significant circadian oscillations. Scaled expression values (-1 to +1) are shown for post-serum-shock and CT time points. Proteins are ordered along the y-axis by peak phase timing. (E) UpSet plot displaying the number of proteins that are rhythmic across each group, separated by males and females. Fill color indicates genotype/lighting condition for C-E (dark blue = LM, light blue = AP, red = CD, orange = CD/AP). ♂ = male, ♀ = female. See also Figures S3 and S4 and Tables S4 and S5.

    Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

    Techniques: Expressing

    A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

    Journal: bioRxiv

    Article Title: Circadian disruption induces sex-specific Alzheimer’s pathophysiology and immune cell reprogramming

    doi: 10.64898/2026.04.30.721994

    Figure Lengend Snippet: A diagrammatic summary of the effects of CD on macrophage circadian function and early AD-related pathology. Standard lighting conditions are depicted by a normal clock (top left), while the CD condition is represented by a distorted clock with misaligned hands (top right). Pictorial representations of male (♂; top row; solid lines) and female (♀; bottom row; dashed lines) APP/PS1 (AP) mouse macrophages, brains, and circadian proteomic oscillations are shown under standard and disrupted lighting conditions (CD/AP). Macrophages and brains appear pink when naïve and red/darker with increased inflammation states. The black dashed arrow indicates peripheral macrophage trafficking toward the brain. Brown tangles represent relative amyloid-β plaque burden. Representative circadian oscillations illustrate average phase relationships and CD-induced phase shifts. Arrows above the oscillations denote the direction and relative magnitude of phase change under CD/AP conditions compared with AP alone. The width of the shaded traces represents the alignment of the phases of the proteins within immunometabolic pathways. “Immunometabolic phase alignment” indicates increased temporal alignment of immunometabolic pathways in female CD/AP macrophages.

    Article Snippet: Hemizygous APPswe/PS1dE9 (APP/PS1) mice and non-transgenic littermate controls were obtained from Jackson Laboratory.

    Techniques: