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s apparent diffusion coefficient adc maps  (Bruker Corporation)


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    Bruker Corporation s apparent diffusion coefficient adc maps
    FIGURE 2 (A) Representative images obtained in one rat at 3 h following the MCAo. The <t>ADC</t> map depicts the core of ischemia (arrow). The time-to-peak map reveals a larger zone of hypoperfusion (arrow). The penumbra was delineated as the mismatch between perfusion and diffusion abnormalities (hatched purple). The StO2-MRI map shows the area with reduced oxygen saturation (arrow). [18F]-FMISO-PET delineates the hypoxic area with increased retention of [18F]-FMISO (arrow). The T2-W image, acquired 24 h after the MCAo, shows the consolidated lesion (arrow). (B) Evolution of ADC-defined lesion volumes. The lesion demonstrable at 15 min expanded at 3 h, and even more so at 24 h following the MCAo. **p < 0.01; ***p < 0.001; ANOVA with repeated measures followed by Tukey's post hoc test. The boxes define the interquartile range; the solid horizontal line the median, and the whiskers represent the minimal and maximal values. (C) Volumes of brain compartments at 3 h following the MCAo. Time-to-peak (TTP): tissue volume with decreased perfusion; Penumbra: tissue with PWI/DWI mismatch; StO2-MRI: tissue that displays a decrease in oxygen saturation; [18F]-FMISO-PET: tissue volume that shows an increased retention of [18F]-FMISO. The boxes define the interquartile range; the solid horizontal line the median and the whiskers represent the minimal and maximal values. ADC, apparent diffusion <t>coefficient;</t> ANOVA, analysis of variance; DWI, diffusion-weighted imaging; MCAo, middle cerebral artery occlusion; PET, positron emission tomography; PWI, perfusion-weighted imaging; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; T2-W, T2-weighted; [18F]-FMISO, 18-fluorine-fluoromisonidazole
    S Apparent Diffusion Coefficient Adc Maps, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 97/100, based on 3085 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Images

    1) Product Images from "Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine-18 fluoromisonidazole-positron emission tomography: A cross-validation study?"

    Article Title: Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine-18 fluoromisonidazole-positron emission tomography: A cross-validation study?

    Journal: NMR in biomedicine

    doi: 10.1002/nbm.4858

    FIGURE 2 (A) Representative images obtained in one rat at 3 h following the MCAo. The ADC map depicts the core of ischemia (arrow). The time-to-peak map reveals a larger zone of hypoperfusion (arrow). The penumbra was delineated as the mismatch between perfusion and diffusion abnormalities (hatched purple). The StO2-MRI map shows the area with reduced oxygen saturation (arrow). [18F]-FMISO-PET delineates the hypoxic area with increased retention of [18F]-FMISO (arrow). The T2-W image, acquired 24 h after the MCAo, shows the consolidated lesion (arrow). (B) Evolution of ADC-defined lesion volumes. The lesion demonstrable at 15 min expanded at 3 h, and even more so at 24 h following the MCAo. **p < 0.01; ***p < 0.001; ANOVA with repeated measures followed by Tukey's post hoc test. The boxes define the interquartile range; the solid horizontal line the median, and the whiskers represent the minimal and maximal values. (C) Volumes of brain compartments at 3 h following the MCAo. Time-to-peak (TTP): tissue volume with decreased perfusion; Penumbra: tissue with PWI/DWI mismatch; StO2-MRI: tissue that displays a decrease in oxygen saturation; [18F]-FMISO-PET: tissue volume that shows an increased retention of [18F]-FMISO. The boxes define the interquartile range; the solid horizontal line the median and the whiskers represent the minimal and maximal values. ADC, apparent diffusion coefficient; ANOVA, analysis of variance; DWI, diffusion-weighted imaging; MCAo, middle cerebral artery occlusion; PET, positron emission tomography; PWI, perfusion-weighted imaging; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; T2-W, T2-weighted; [18F]-FMISO, 18-fluorine-fluoromisonidazole
    Figure Legend Snippet: FIGURE 2 (A) Representative images obtained in one rat at 3 h following the MCAo. The ADC map depicts the core of ischemia (arrow). The time-to-peak map reveals a larger zone of hypoperfusion (arrow). The penumbra was delineated as the mismatch between perfusion and diffusion abnormalities (hatched purple). The StO2-MRI map shows the area with reduced oxygen saturation (arrow). [18F]-FMISO-PET delineates the hypoxic area with increased retention of [18F]-FMISO (arrow). The T2-W image, acquired 24 h after the MCAo, shows the consolidated lesion (arrow). (B) Evolution of ADC-defined lesion volumes. The lesion demonstrable at 15 min expanded at 3 h, and even more so at 24 h following the MCAo. **p < 0.01; ***p < 0.001; ANOVA with repeated measures followed by Tukey's post hoc test. The boxes define the interquartile range; the solid horizontal line the median, and the whiskers represent the minimal and maximal values. (C) Volumes of brain compartments at 3 h following the MCAo. Time-to-peak (TTP): tissue volume with decreased perfusion; Penumbra: tissue with PWI/DWI mismatch; StO2-MRI: tissue that displays a decrease in oxygen saturation; [18F]-FMISO-PET: tissue volume that shows an increased retention of [18F]-FMISO. The boxes define the interquartile range; the solid horizontal line the median and the whiskers represent the minimal and maximal values. ADC, apparent diffusion coefficient; ANOVA, analysis of variance; DWI, diffusion-weighted imaging; MCAo, middle cerebral artery occlusion; PET, positron emission tomography; PWI, perfusion-weighted imaging; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; T2-W, T2-weighted; [18F]-FMISO, 18-fluorine-fluoromisonidazole

    Techniques Used: Diffusion-based Assay, Imaging, Positron Emission Tomography, Magnetic Resonance Imaging

    FIGURE 5 Representative images of StO2-MRI, [18F]-FMISO-PET, and the superimposition of both abnormalities on the ADC image for each animal. StO2-MRI abnormality is delinated in yellow and [18F]-FMISO-PET abnormality in green. ADC, apparent diffusion coefficient; [18F]-FMISO, 18-fluorine-fluoromisonidazole; PET, positron emission tomography; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; SUV, standardized uptake value
    Figure Legend Snippet: FIGURE 5 Representative images of StO2-MRI, [18F]-FMISO-PET, and the superimposition of both abnormalities on the ADC image for each animal. StO2-MRI abnormality is delinated in yellow and [18F]-FMISO-PET abnormality in green. ADC, apparent diffusion coefficient; [18F]-FMISO, 18-fluorine-fluoromisonidazole; PET, positron emission tomography; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; SUV, standardized uptake value

    Techniques Used: Diffusion-based Assay, Positron Emission Tomography, Magnetic Resonance Imaging

    Related Articles

    Mass Spectrometry:

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited
    Article Snippet: .. Gu (2024) [ ] , Skin swab , MALDI-TOF Mass Spectrometry (Bruker) , Kirby Bauer disk diffusion test (Etest) , CLSI , PEN-susceptible. .. Lampejo (2024) [ ] , Blood culture , MALDI-TOF Mass Spectrometry , Kirby Bauer disk diffusion test , EUCAST , CLI-, PEN-, VA-susceptible. MTZ-resistant.

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited.
    Article Snippet: .. Author Year Reference Type of Sample Method of Identification Method ofSusceptibility Testing Interpretation Criteria Antibiotics Resistance Phenotype (MIC mg/L) Chinello (2025) [28] Material drained from orbital cellulitis MALDI-TOF Mass Spectrometry NR NR AMC < 0.016, AZY 2, CLI > 256, DAPTO 4, LZD 0.19, MEM 0.012, MTZ > 256, TZP < 0.016 Faiz (2025) [29] Intraoperative sample from abscess MALDI-TOF Mass Spectrometry (Bruker) Kirby Bauer disk diffusion test EUCAST 2023 breakpoint for Corynebacterium CLI-, LIN-, RIF-, TET-susceptible CIP-, MOX-, PEN-, SXT-, VA-resistant Lovering (2025) [30] Blood culture MALDI-TOF MassSpectrometry NR NR CN, CRO, LZD, MEM, PEN, VA susceptible Saijo (2025) [31] Intraoperative sample from debridement MALDI-TOF Mass Spectrometry NR NR CRO 0.5, FEP 2, CTX 0.5, ERY < 0.12, PEN 0.25, RIF < 1, SXT < 0.5, VA 0.5 Bozso (2024) [32] Blood culture NR NR NR CLI ≤ 0.016, PEN ≤ 0.03 Chang (2024) [33] Blood culture, intraoperative samples from abscess NR NR NR NR Chin (2024) [34] Intraoperative sample from abscess NR NR NR NR Grusiecki (2024) [35] Purulent material from abscess NR NR NR PEN-susceptible CIP-, CLI-, MXF-resistant Gu (2024) [36] Skin swab MALDI-TOF Mass Spectrometry (Bruker) Kirby Bauer disk diffusion test (Etest) CLSI PEN-susceptible https://doi.org/10.3390/pathogens15030335 Table 3. ..

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited.
    Article Snippet: .. MTZ-resistant Alrwashdeh (2023) [38] Blood culture and BAL MALDI-TOF MassSpectrometry NR PEN-susceptible Herai (2023) [39] Pleural fluid MALDI-TOF Mass Spectrometry (Bruker) NR NR NR Sahhar (2023) [40] Intraoperative sample from abscess MALDI-TOF Mass Spectrometry (Bruker) Kirby Bauer diffusion test (Disks and Etest) NR CLI-, CRO-, DOX-, LEV-, LZD-, PEN, RIF-, VA-susceptible Hicks (2022) [41] Intraoperative sample from abscess MALDI-TOF Mass Spectrometry Kirby Bauer diffusion test (Etest) NR PEN 0.064 Thomas (2022) [42] Intraoperative sample from debridement NR NR NR NR Purulent material from wound NR NR NR NR Purulent material from wound NR NR NR NR Intraoperative sample from debridement NR NR NR NR Intraoperative sample from debridement NR NR NR NR Purulent material from ulcer NR NR NR NR https://doi.org/10.3390/pathogens15030335 Table 3. ..

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited
    Article Snippet: Herai (2023) [ ] , Pleural fluid , MALDI-TOF Mass Spectrometry (Bruker) , NR , NR , NR. .. Sahhar (2023) [ ] , Intraoperative sample from abscess , MALDI-TOF Mass Spectrometry (Bruker) , Kirby Bauer diffusion test (Disks and Etest) , NR , CLI-, CRO-, DOX-, LEV-, LZD-, PEN, RIF-, VA-susceptible. .. Hicks (2022) [ ] , Intraoperative sample from abscess , MALDI-TOF Mass Spectrometry , Kirby Bauer diffusion test (Etest) , NR , PEN 0.064.

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited
    Article Snippet: Chinello (2025) [ ] , Material drained from orbital cellulitis , MALDI-TOF Mass Spectrometry , NR , NR , AMC < 0.016, AZY 2, CLI > 256, DAPTO 4, LZD 0.19, MEM 0.012, MTZ > 256, TZP < 0.016. .. Faiz (2025) [ ] , Intraoperative sample from abscess , MALDI-TOF Mass Spectrometry (Bruker) , Kirby Bauer disk diffusion test , EUCAST 2023 breakpoint for Corynebacterium , CLI-, LIN-, RIF-, TET-susceptible CIP-, MOX-, PEN-, SXT-, VA-resistant. .. Lovering (2025) [ ] , Blood culture , MALDI-TOF Mass Spectrometry , NR , NR , CN, CRO, LZD, MEM, PEN, VA susceptible.

    Diffusion-based Assay:

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited
    Article Snippet: .. Gu (2024) [ ] , Skin swab , MALDI-TOF Mass Spectrometry (Bruker) , Kirby Bauer disk diffusion test (Etest) , CLSI , PEN-susceptible. .. Lampejo (2024) [ ] , Blood culture , MALDI-TOF Mass Spectrometry , Kirby Bauer disk diffusion test , EUCAST , CLI-, PEN-, VA-susceptible. MTZ-resistant.

    Article Title: Potassium Hexafluoroacetylacetonate Complex with 18-Crown-6 Ether as a Volatile Precursor of Molecular and Inorganic Films: Thermal and Structural Insights.
    Article Snippet: The 1H DOSY NMR experiment [85,86] was performed on the same equipment with a 5 mm BBI probe with z-gradient. .. Diffusion coefficients were measured using the standard Bruker Ledbpgp2s sequence. ..

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited.
    Article Snippet: .. Author Year Reference Type of Sample Method of Identification Method ofSusceptibility Testing Interpretation Criteria Antibiotics Resistance Phenotype (MIC mg/L) Chinello (2025) [28] Material drained from orbital cellulitis MALDI-TOF Mass Spectrometry NR NR AMC < 0.016, AZY 2, CLI > 256, DAPTO 4, LZD 0.19, MEM 0.012, MTZ > 256, TZP < 0.016 Faiz (2025) [29] Intraoperative sample from abscess MALDI-TOF Mass Spectrometry (Bruker) Kirby Bauer disk diffusion test EUCAST 2023 breakpoint for Corynebacterium CLI-, LIN-, RIF-, TET-susceptible CIP-, MOX-, PEN-, SXT-, VA-resistant Lovering (2025) [30] Blood culture MALDI-TOF MassSpectrometry NR NR CN, CRO, LZD, MEM, PEN, VA susceptible Saijo (2025) [31] Intraoperative sample from debridement MALDI-TOF Mass Spectrometry NR NR CRO 0.5, FEP 2, CTX 0.5, ERY < 0.12, PEN 0.25, RIF < 1, SXT < 0.5, VA 0.5 Bozso (2024) [32] Blood culture NR NR NR CLI ≤ 0.016, PEN ≤ 0.03 Chang (2024) [33] Blood culture, intraoperative samples from abscess NR NR NR NR Chin (2024) [34] Intraoperative sample from abscess NR NR NR NR Grusiecki (2024) [35] Purulent material from abscess NR NR NR PEN-susceptible CIP-, CLI-, MXF-resistant Gu (2024) [36] Skin swab MALDI-TOF Mass Spectrometry (Bruker) Kirby Bauer disk diffusion test (Etest) CLSI PEN-susceptible https://doi.org/10.3390/pathogens15030335 Table 3. ..

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited.
    Article Snippet: .. MTZ-resistant Alrwashdeh (2023) [38] Blood culture and BAL MALDI-TOF MassSpectrometry NR PEN-susceptible Herai (2023) [39] Pleural fluid MALDI-TOF Mass Spectrometry (Bruker) NR NR NR Sahhar (2023) [40] Intraoperative sample from abscess MALDI-TOF Mass Spectrometry (Bruker) Kirby Bauer diffusion test (Disks and Etest) NR CLI-, CRO-, DOX-, LEV-, LZD-, PEN, RIF-, VA-susceptible Hicks (2022) [41] Intraoperative sample from abscess MALDI-TOF Mass Spectrometry Kirby Bauer diffusion test (Etest) NR PEN 0.064 Thomas (2022) [42] Intraoperative sample from debridement NR NR NR NR Purulent material from wound NR NR NR NR Purulent material from wound NR NR NR NR Intraoperative sample from debridement NR NR NR NR Intraoperative sample from debridement NR NR NR NR Purulent material from ulcer NR NR NR NR https://doi.org/10.3390/pathogens15030335 Table 3. ..

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited
    Article Snippet: Herai (2023) [ ] , Pleural fluid , MALDI-TOF Mass Spectrometry (Bruker) , NR , NR , NR. .. Sahhar (2023) [ ] , Intraoperative sample from abscess , MALDI-TOF Mass Spectrometry (Bruker) , Kirby Bauer diffusion test (Disks and Etest) , NR , CLI-, CRO-, DOX-, LEV-, LZD-, PEN, RIF-, VA-susceptible. .. Hicks (2022) [ ] , Intraoperative sample from abscess , MALDI-TOF Mass Spectrometry , Kirby Bauer diffusion test (Etest) , NR , PEN 0.064.

    Article Title: Physical and chemical characterisation of ophthalmic lens-grinding wastewater: uncovering environmental implications.
    Article Snippet: .. 1D 1H and 2D 1H-1H NMR DOSY (Diffusion-ordered spectroscopy) experiments were carried out on a 9.4 T Bruker AVANCE III 400 spectrometer (Bruker Corporation, Billerica MA, USA) equipped with a Bruker DiffBB probe, specifically a 5 mm high-power diffusion BBI probe. ..

    Article Title: Insights into Arcanobacterium haemolyticum : A Narrative Review of an Emerging Pathogen Revisited
    Article Snippet: Chinello (2025) [ ] , Material drained from orbital cellulitis , MALDI-TOF Mass Spectrometry , NR , NR , AMC < 0.016, AZY 2, CLI > 256, DAPTO 4, LZD 0.19, MEM 0.012, MTZ > 256, TZP < 0.016. .. Faiz (2025) [ ] , Intraoperative sample from abscess , MALDI-TOF Mass Spectrometry (Bruker) , Kirby Bauer disk diffusion test , EUCAST 2023 breakpoint for Corynebacterium , CLI-, LIN-, RIF-, TET-susceptible CIP-, MOX-, PEN-, SXT-, VA-resistant. .. Lovering (2025) [ ] , Blood culture , MALDI-TOF Mass Spectrometry , NR , NR , CN, CRO, LZD, MEM, PEN, VA susceptible.

    Sequencing:

    Article Title: Potassium Hexafluoroacetylacetonate Complex with 18-Crown-6 Ether as a Volatile Precursor of Molecular and Inorganic Films: Thermal and Structural Insights.
    Article Snippet: The 1H DOSY NMR experiment [85,86] was performed on the same equipment with a 5 mm BBI probe with z-gradient. .. Diffusion coefficients were measured using the standard Bruker Ledbpgp2s sequence. ..

    Nuclear Magnetic Resonance:

    Article Title: Physical and chemical characterisation of ophthalmic lens-grinding wastewater: uncovering environmental implications.
    Article Snippet: .. 1D 1H and 2D 1H-1H NMR DOSY (Diffusion-ordered spectroscopy) experiments were carried out on a 9.4 T Bruker AVANCE III 400 spectrometer (Bruker Corporation, Billerica MA, USA) equipped with a Bruker DiffBB probe, specifically a 5 mm high-power diffusion BBI probe. ..

    Spectroscopy:

    Article Title: Physical and chemical characterisation of ophthalmic lens-grinding wastewater: uncovering environmental implications.
    Article Snippet: .. 1D 1H and 2D 1H-1H NMR DOSY (Diffusion-ordered spectroscopy) experiments were carried out on a 9.4 T Bruker AVANCE III 400 spectrometer (Bruker Corporation, Billerica MA, USA) equipped with a Bruker DiffBB probe, specifically a 5 mm high-power diffusion BBI probe. ..



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    FIGURE 2 (A) Representative images obtained in one rat at 3 h following the MCAo. The <t>ADC</t> map depicts the core of ischemia (arrow). The time-to-peak map reveals a larger zone of hypoperfusion (arrow). The penumbra was delineated as the mismatch between perfusion and diffusion abnormalities (hatched purple). The StO2-MRI map shows the area with reduced oxygen saturation (arrow). [18F]-FMISO-PET delineates the hypoxic area with increased retention of [18F]-FMISO (arrow). The T2-W image, acquired 24 h after the MCAo, shows the consolidated lesion (arrow). (B) Evolution of ADC-defined lesion volumes. The lesion demonstrable at 15 min expanded at 3 h, and even more so at 24 h following the MCAo. **p < 0.01; ***p < 0.001; ANOVA with repeated measures followed by Tukey's post hoc test. The boxes define the interquartile range; the solid horizontal line the median, and the whiskers represent the minimal and maximal values. (C) Volumes of brain compartments at 3 h following the MCAo. Time-to-peak (TTP): tissue volume with decreased perfusion; Penumbra: tissue with PWI/DWI mismatch; StO2-MRI: tissue that displays a decrease in oxygen saturation; [18F]-FMISO-PET: tissue volume that shows an increased retention of [18F]-FMISO. The boxes define the interquartile range; the solid horizontal line the median and the whiskers represent the minimal and maximal values. ADC, apparent diffusion <t>coefficient;</t> ANOVA, analysis of variance; DWI, diffusion-weighted imaging; MCAo, middle cerebral artery occlusion; PET, positron emission tomography; PWI, perfusion-weighted imaging; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; T2-W, T2-weighted; [18F]-FMISO, 18-fluorine-fluoromisonidazole
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    FIGURE 2 (A) Representative images obtained in one rat at 3 h following the MCAo. The <t>ADC</t> map depicts the core of ischemia (arrow). The time-to-peak map reveals a larger zone of hypoperfusion (arrow). The penumbra was delineated as the mismatch between perfusion and diffusion abnormalities (hatched purple). The StO2-MRI map shows the area with reduced oxygen saturation (arrow). [18F]-FMISO-PET delineates the hypoxic area with increased retention of [18F]-FMISO (arrow). The T2-W image, acquired 24 h after the MCAo, shows the consolidated lesion (arrow). (B) Evolution of ADC-defined lesion volumes. The lesion demonstrable at 15 min expanded at 3 h, and even more so at 24 h following the MCAo. **p < 0.01; ***p < 0.001; ANOVA with repeated measures followed by Tukey's post hoc test. The boxes define the interquartile range; the solid horizontal line the median, and the whiskers represent the minimal and maximal values. (C) Volumes of brain compartments at 3 h following the MCAo. Time-to-peak (TTP): tissue volume with decreased perfusion; Penumbra: tissue with PWI/DWI mismatch; StO2-MRI: tissue that displays a decrease in oxygen saturation; [18F]-FMISO-PET: tissue volume that shows an increased retention of [18F]-FMISO. The boxes define the interquartile range; the solid horizontal line the median and the whiskers represent the minimal and maximal values. ADC, apparent diffusion <t>coefficient;</t> ANOVA, analysis of variance; DWI, diffusion-weighted imaging; MCAo, middle cerebral artery occlusion; PET, positron emission tomography; PWI, perfusion-weighted imaging; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; T2-W, T2-weighted; [18F]-FMISO, 18-fluorine-fluoromisonidazole
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    A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion coefficient (ADC) observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.

    Journal: bioRxiv

    Article Title: Multimodal Characterization and Evolution of Malonate-induced Stroke Model: Advanced MRI, Histology-Molecular Profiling

    doi: 10.1101/2025.10.22.684053

    Figure Lengend Snippet: A. The percentage of viable and necrotic tissue with respect to the total lesion volume. B.The evolution of vessel radius (R). C. Blood volume fraction (BVF). D. Oxygen saturation (StO 2 ) E. Signal enhancement F. Apparent diffusion coefficient (ADC) observed by MRI at D4, D7, D14, D28, and D56 after ischemic injury by malonate injection. n=5 at D4, n=13 at D7, n=8 at D14, n=8 at D28 and n=7 at D56. Data is represented by medians and IQR. *: 0.03>p>0.01, **: 0.005>p>0.001, ***: 0.0005>p>0.0001, ****: p<0.0001 vs contralateral hemisphere, paired non-parametric Mann-Whitney test.

    Article Snippet: Apparent diffusion coefficient (ADC) maps were automatically computed on the Bruker scanner as the means of the ADCs observed in each of three orthogonal directions.

    Techniques: Diffusion-based Assay, Injection, MANN-WHITNEY

    FIGURE 2 (A) Representative images obtained in one rat at 3 h following the MCAo. The ADC map depicts the core of ischemia (arrow). The time-to-peak map reveals a larger zone of hypoperfusion (arrow). The penumbra was delineated as the mismatch between perfusion and diffusion abnormalities (hatched purple). The StO2-MRI map shows the area with reduced oxygen saturation (arrow). [18F]-FMISO-PET delineates the hypoxic area with increased retention of [18F]-FMISO (arrow). The T2-W image, acquired 24 h after the MCAo, shows the consolidated lesion (arrow). (B) Evolution of ADC-defined lesion volumes. The lesion demonstrable at 15 min expanded at 3 h, and even more so at 24 h following the MCAo. **p < 0.01; ***p < 0.001; ANOVA with repeated measures followed by Tukey's post hoc test. The boxes define the interquartile range; the solid horizontal line the median, and the whiskers represent the minimal and maximal values. (C) Volumes of brain compartments at 3 h following the MCAo. Time-to-peak (TTP): tissue volume with decreased perfusion; Penumbra: tissue with PWI/DWI mismatch; StO2-MRI: tissue that displays a decrease in oxygen saturation; [18F]-FMISO-PET: tissue volume that shows an increased retention of [18F]-FMISO. The boxes define the interquartile range; the solid horizontal line the median and the whiskers represent the minimal and maximal values. ADC, apparent diffusion coefficient; ANOVA, analysis of variance; DWI, diffusion-weighted imaging; MCAo, middle cerebral artery occlusion; PET, positron emission tomography; PWI, perfusion-weighted imaging; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; T2-W, T2-weighted; [18F]-FMISO, 18-fluorine-fluoromisonidazole

    Journal: NMR in biomedicine

    Article Title: Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine-18 fluoromisonidazole-positron emission tomography: A cross-validation study?

    doi: 10.1002/nbm.4858

    Figure Lengend Snippet: FIGURE 2 (A) Representative images obtained in one rat at 3 h following the MCAo. The ADC map depicts the core of ischemia (arrow). The time-to-peak map reveals a larger zone of hypoperfusion (arrow). The penumbra was delineated as the mismatch between perfusion and diffusion abnormalities (hatched purple). The StO2-MRI map shows the area with reduced oxygen saturation (arrow). [18F]-FMISO-PET delineates the hypoxic area with increased retention of [18F]-FMISO (arrow). The T2-W image, acquired 24 h after the MCAo, shows the consolidated lesion (arrow). (B) Evolution of ADC-defined lesion volumes. The lesion demonstrable at 15 min expanded at 3 h, and even more so at 24 h following the MCAo. **p < 0.01; ***p < 0.001; ANOVA with repeated measures followed by Tukey's post hoc test. The boxes define the interquartile range; the solid horizontal line the median, and the whiskers represent the minimal and maximal values. (C) Volumes of brain compartments at 3 h following the MCAo. Time-to-peak (TTP): tissue volume with decreased perfusion; Penumbra: tissue with PWI/DWI mismatch; StO2-MRI: tissue that displays a decrease in oxygen saturation; [18F]-FMISO-PET: tissue volume that shows an increased retention of [18F]-FMISO. The boxes define the interquartile range; the solid horizontal line the median and the whiskers represent the minimal and maximal values. ADC, apparent diffusion coefficient; ANOVA, analysis of variance; DWI, diffusion-weighted imaging; MCAo, middle cerebral artery occlusion; PET, positron emission tomography; PWI, perfusion-weighted imaging; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; T2-W, T2-weighted; [18F]-FMISO, 18-fluorine-fluoromisonidazole

    Article Snippet: The following parameters were employed: resolution = 0.3 x 0.3 x 1.5 mm, FOV = 31.5 x 15 x 15 mm; TR/TE = 3000/46.4 ms; b-values: 0 and 1000 s/mm2; 30 directions; number of experiments (NEX) = 3; and acquisi- tion time: 5 min 15 s. Apparent diffusion coefficient (ADC) maps were then generated with PV 5.1 software (Bruker).

    Techniques: Diffusion-based Assay, Imaging, Positron Emission Tomography, Magnetic Resonance Imaging

    FIGURE 5 Representative images of StO2-MRI, [18F]-FMISO-PET, and the superimposition of both abnormalities on the ADC image for each animal. StO2-MRI abnormality is delinated in yellow and [18F]-FMISO-PET abnormality in green. ADC, apparent diffusion coefficient; [18F]-FMISO, 18-fluorine-fluoromisonidazole; PET, positron emission tomography; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; SUV, standardized uptake value

    Journal: NMR in biomedicine

    Article Title: Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine-18 fluoromisonidazole-positron emission tomography: A cross-validation study?

    doi: 10.1002/nbm.4858

    Figure Lengend Snippet: FIGURE 5 Representative images of StO2-MRI, [18F]-FMISO-PET, and the superimposition of both abnormalities on the ADC image for each animal. StO2-MRI abnormality is delinated in yellow and [18F]-FMISO-PET abnormality in green. ADC, apparent diffusion coefficient; [18F]-FMISO, 18-fluorine-fluoromisonidazole; PET, positron emission tomography; StO2-MRI, magnetic resonance-based imaging of brain oxygen saturation; SUV, standardized uptake value

    Article Snippet: The following parameters were employed: resolution = 0.3 x 0.3 x 1.5 mm, FOV = 31.5 x 15 x 15 mm; TR/TE = 3000/46.4 ms; b-values: 0 and 1000 s/mm2; 30 directions; number of experiments (NEX) = 3; and acquisi- tion time: 5 min 15 s. Apparent diffusion coefficient (ADC) maps were then generated with PV 5.1 software (Bruker).

    Techniques: Diffusion-based Assay, Positron Emission Tomography, Magnetic Resonance Imaging