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ap39  (MedChemExpress)


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    MedChemExpress ap39
    Ap39, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ap39/AP39/pm39848475-44-9-16
    Average 94 stars, based on 10 article reviews
    ap39 - by Bioz Stars, 2026-11
    94/100 stars

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    Related Articles

    Control:

    Article Title: UW Supplementation with AP39 Improves Liver Viability Following Static Cold Storage
    Article Snippet: .. The liver was immediately weighed, and subsequently either perfused for 6 hours at 37°C as described below (fresh control, n = 4), or ushed Page 5/19 with UW with 200 nM AP39 (MedChemExpress, Monmouth Junction NJ, USA, n = 6) or vehicle (0.13% v/v dichloromethane) and stored on ice in the same respective solution for 3 days. ..

    Article Title: TorPause: Efficient Static Organ Preservation for Transplants
    Article Snippet: .. Perfusate defined the treatment group: UW alone (Control), or UW containing AP39 (3 μM, MedChemExpress, Monmouth Junction, NJ), GSK212 (2 μM, MedChemExpress, Monmouth Junction, NJ), or AP39 (3 μM) plus GSK212 (2 μM) (Combination); small molecules were diluted from DMSO stocks, with Control perfusate matched for DMSO (0.1% v/v). ..

    Article Title: UW supplementation with AP39 improves liver viability following static cold storage
    Article Snippet: .. The liver was immediately weighed, and subsequently either perfused for 6 h at 37 °C as described below (fresh control, n = 4), or flushed with UW with 200 nM AP39 (MedChemExpress, Monmouth Junction NJ, USA, n = 6) or vehicle (0.13% v/v dichloromethane, n = 6) and stored at 4 °C in the same respective solution for 3 days. ..

    other:

    Article Title: A Mitochondria-Modulating Nanosystem for Rheumatoid Arthritis Immunotherapy via Inflammatory Cascade Disruption.
    Article Snippet: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation within joints, where macrophage-driven inflammatory cascade caused by mitochondrial dysfunction significantly contributes to the pathogenesis.. Through recruitment and activation of neutrophils from circulation, these macrophages promote the release of neutrophil extracellular traps (NETs) and generation of reactive oxygen species (ROS), leading to synovitis exacerbation and tissue damage.. To disrupt this closely linked cycle, we present a mitochondria-modulating nanosystem (NM@APDAase) targeting the inflammatory cascade for RA immunotherapy.



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    Image Search Results


    Physicochemical Properties of AP39. Results are Presented as the Mean ± Standard Deviation. n=4 Independent Batches

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Physicochemical Properties of AP39. Results are Presented as the Mean ± Standard Deviation. n=4 Independent Batches

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Standard Deviation, Solubility

    Liposome Characteristics Showcasing Size, Polydispersity, Zeta Potential, and Entrapment Efficiency. Data Represents Mean ± SD. n=6 Independent Batches

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Liposome Characteristics Showcasing Size, Polydispersity, Zeta Potential, and Entrapment Efficiency. Data Represents Mean ± SD. n=6 Independent Batches

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Zeta Potential Analyzer, Liposomes

    Cell viability evaluated on ( A ) HUVEC and ( B ) SHSY5Y cells following the application of AP39 in solution (non-formulated) and formulated AP39 into liposomes, assessed by LDH release. The percentage release of LDH (cytotoxicity) of each sample was subtracted from 100% viability of control (after 4 h of exposure). Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches.

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Cell viability evaluated on ( A ) HUVEC and ( B ) SHSY5Y cells following the application of AP39 in solution (non-formulated) and formulated AP39 into liposomes, assessed by LDH release. The percentage release of LDH (cytotoxicity) of each sample was subtracted from 100% viability of control (after 4 h of exposure). Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches.

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Liposomes, Control

    Liposomal AP39 provided a slow and sustained ( A ) cellular uptake of AP39 and ( B ) release of H 2 S from formulated AP39 compared to non-formulated AP39 on SHSY5Y cells. Hourly H 2 S release values are plotted with curve-fitting results to highlight the donor compound decomposition. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. ***p ≤ 0.001.

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Liposomal AP39 provided a slow and sustained ( A ) cellular uptake of AP39 and ( B ) release of H 2 S from formulated AP39 compared to non-formulated AP39 on SHSY5Y cells. Hourly H 2 S release values are plotted with curve-fitting results to highlight the donor compound decomposition. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. ***p ≤ 0.001.

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques:

    Liposomal AP39 formulation enhances the directional permeability of AP39. ( A ) AP39 permeation across a microvascular endothelial barrier model mimicking the Blood-Brain Barrier ( B ) TEER values measured following growth of HUVEC on permeable cell culture inserts (24-well, 0.33 cm2) under static conditions, before and after tight junction inducers. ( C ) AP39 apical to basolateral transport. ( D ) basolateral to apical transport. ( E ) Associated apparent membrane permeability (P app ) values in both directions. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 6. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Liposomal AP39 formulation enhances the directional permeability of AP39. ( A ) AP39 permeation across a microvascular endothelial barrier model mimicking the Blood-Brain Barrier ( B ) TEER values measured following growth of HUVEC on permeable cell culture inserts (24-well, 0.33 cm2) under static conditions, before and after tight junction inducers. ( C ) AP39 apical to basolateral transport. ( D ) basolateral to apical transport. ( E ) Associated apparent membrane permeability (P app ) values in both directions. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 6. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Formulation, Permeability, Cell Culture, Membrane

    Mitochondrial oxygen consumption rates determined in SHSY5Y exposed to AP39 (in formulation or not) and in combination with H 2 O 2 (300 µM) for 1h. ( A ) Sequential injections of Oligomycin, FCCP and mixture of Rotenone and Antimycin A allowed to calculate the parameters of mitochondrial function, ( B ) basal respiration and maximal respiration. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Mitochondrial oxygen consumption rates determined in SHSY5Y exposed to AP39 (in formulation or not) and in combination with H 2 O 2 (300 µM) for 1h. ( A ) Sequential injections of Oligomycin, FCCP and mixture of Rotenone and Antimycin A allowed to calculate the parameters of mitochondrial function, ( B ) basal respiration and maximal respiration. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Formulation