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ap39  (MedChemExpress)


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    MedChemExpress ap39
    Ap39, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ap39/AP39/pm39848475-44-9-16
    Average 94 stars, based on 9 article reviews
    ap39 - by Bioz Stars, 2026-10
    94/100 stars

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    Control:

    Article Title: UW Supplementation with AP39 Improves Liver Viability Following Static Cold Storage
    Article Snippet: .. The liver was immediately weighed, and subsequently either perfused for 6 hours at 37°C as described below (fresh control, n = 4), or ushed Page 5/19 with UW with 200 nM AP39 (MedChemExpress, Monmouth Junction NJ, USA, n = 6) or vehicle (0.13% v/v dichloromethane) and stored on ice in the same respective solution for 3 days. ..

    Article Title: TorPause: Efficient Static Organ Preservation for Transplants
    Article Snippet: .. Perfusate defined the treatment group: UW alone (Control), or UW containing AP39 (3 μM, MedChemExpress, Monmouth Junction, NJ), GSK212 (2 μM, MedChemExpress, Monmouth Junction, NJ), or AP39 (3 μM) plus GSK212 (2 μM) (Combination); small molecules were diluted from DMSO stocks, with Control perfusate matched for DMSO (0.1% v/v). ..

    Article Title: UW supplementation with AP39 improves liver viability following static cold storage
    Article Snippet: .. The liver was immediately weighed, and subsequently either perfused for 6 h at 37 °C as described below (fresh control, n = 4), or flushed with UW with 200 nM AP39 (MedChemExpress, Monmouth Junction NJ, USA, n = 6) or vehicle (0.13% v/v dichloromethane, n = 6) and stored at 4 °C in the same respective solution for 3 days. ..



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    Image Search Results


    Physicochemical Properties of AP39. Results are Presented as the Mean ± Standard Deviation. n=4 Independent Batches

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Physicochemical Properties of AP39. Results are Presented as the Mean ± Standard Deviation. n=4 Independent Batches

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Standard Deviation, Solubility

    Liposome Characteristics Showcasing Size, Polydispersity, Zeta Potential, and Entrapment Efficiency. Data Represents Mean ± SD. n=6 Independent Batches

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Liposome Characteristics Showcasing Size, Polydispersity, Zeta Potential, and Entrapment Efficiency. Data Represents Mean ± SD. n=6 Independent Batches

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Zeta Potential Analyzer, Liposomes

    Cell viability evaluated on ( A ) HUVEC and ( B ) SHSY5Y cells following the application of AP39 in solution (non-formulated) and formulated AP39 into liposomes, assessed by LDH release. The percentage release of LDH (cytotoxicity) of each sample was subtracted from 100% viability of control (after 4 h of exposure). Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches.

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Cell viability evaluated on ( A ) HUVEC and ( B ) SHSY5Y cells following the application of AP39 in solution (non-formulated) and formulated AP39 into liposomes, assessed by LDH release. The percentage release of LDH (cytotoxicity) of each sample was subtracted from 100% viability of control (after 4 h of exposure). Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches.

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Liposomes, Control

    Liposomal AP39 provided a slow and sustained ( A ) cellular uptake of AP39 and ( B ) release of H 2 S from formulated AP39 compared to non-formulated AP39 on SHSY5Y cells. Hourly H 2 S release values are plotted with curve-fitting results to highlight the donor compound decomposition. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. ***p ≤ 0.001.

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Liposomal AP39 provided a slow and sustained ( A ) cellular uptake of AP39 and ( B ) release of H 2 S from formulated AP39 compared to non-formulated AP39 on SHSY5Y cells. Hourly H 2 S release values are plotted with curve-fitting results to highlight the donor compound decomposition. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. ***p ≤ 0.001.

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques:

    Liposomal AP39 formulation enhances the directional permeability of AP39. ( A ) AP39 permeation across a microvascular endothelial barrier model mimicking the Blood-Brain Barrier ( B ) TEER values measured following growth of HUVEC on permeable cell culture inserts (24-well, 0.33 cm2) under static conditions, before and after tight junction inducers. ( C ) AP39 apical to basolateral transport. ( D ) basolateral to apical transport. ( E ) Associated apparent membrane permeability (P app ) values in both directions. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 6. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Liposomal AP39 formulation enhances the directional permeability of AP39. ( A ) AP39 permeation across a microvascular endothelial barrier model mimicking the Blood-Brain Barrier ( B ) TEER values measured following growth of HUVEC on permeable cell culture inserts (24-well, 0.33 cm2) under static conditions, before and after tight junction inducers. ( C ) AP39 apical to basolateral transport. ( D ) basolateral to apical transport. ( E ) Associated apparent membrane permeability (P app ) values in both directions. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 6. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Formulation, Permeability, Cell Culture, Membrane

    Mitochondrial oxygen consumption rates determined in SHSY5Y exposed to AP39 (in formulation or not) and in combination with H 2 O 2 (300 µM) for 1h. ( A ) Sequential injections of Oligomycin, FCCP and mixture of Rotenone and Antimycin A allowed to calculate the parameters of mitochondrial function, ( B ) basal respiration and maximal respiration. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.

    Journal: Drug Design, Development and Therapy

    Article Title: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells

    doi: 10.2147/DDDT.S507697

    Figure Lengend Snippet: Mitochondrial oxygen consumption rates determined in SHSY5Y exposed to AP39 (in formulation or not) and in combination with H 2 O 2 (300 µM) for 1h. ( A ) Sequential injections of Oligomycin, FCCP and mixture of Rotenone and Antimycin A allowed to calculate the parameters of mitochondrial function, ( B ) basal respiration and maximal respiration. Results are expressed as mean ± SD and analysed by one-way ANOVA. n = 5 independent batches. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001.

    Article Snippet: AP39 was obtained from Cayman Chemicals (catalogue no.17100).

    Techniques: Formulation