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amitriptyline hydrochloride amt  (Lundbeck)

 
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    Lundbeck amitriptyline hydrochloride amt
    Data of four APIs and tentatively identified metabolites. If no CCS values are provided, the ion abundance was too low for accurate CCS determination
    Amitriptyline Hydrochloride Amt, supplied by Lundbeck, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/amitriptyline+amt/amitriptyline/pmc10927770-52-0-3
    Average 90 stars, based on 1 article reviews
    amitriptyline hydrochloride amt - by Bioz Stars, 2026-11
    90/100 stars

    Images

    1) Product Images from "Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea"

    Article Title: Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea

    Journal: Environmental Science and Pollution Research International

    doi: 10.1007/s11356-024-32379-x

    Data of four APIs and tentatively identified metabolites. If no CCS values are provided, the ion abundance was too low for accurate CCS determination
    Figure Legend Snippet: Data of four APIs and tentatively identified metabolites. If no CCS values are provided, the ion abundance was too low for accurate CCS determination

    Techniques Used:

    Related Articles

    other:

    Article Title: Involvement of adenosine in the effect of antidepressants on glutamate and aspartate release in the rat prefrontal cortex.
    Article Snippet: The effect of local administration of amitriptyline (AMI), desipramine (DMI) and citalopram (CIT) on veratridine-evoked glutamate (Glu) and aspartate (Asp) release in the prefrontal cortex of the conscious rat was examined using in vivo reverse microdialysis.. The antidepressants (each at 100 μM) significantly reduced Glu and Asp release.. The effect of AMI and CIT was attenuated by i.p. administration of the adenosine A1/A2A receptor antagonist caffeine (10 mg/kg), or by local infusion of the adenosine A1 receptor antagonist 8-cyclopentyltheophylline (CPT, 75 μM).

    Article Title: The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomised placebo-controlled study on healthy volunteers.
    Article Snippet: Rationale: In therapeutic use, amitriptyline, reboxetine and citalopram have all been associated with apparent anticholinergic-like side effects (dry mouth, constipation, etc.), despite the very low antimuscarinic activity of reboxetine and citalopram in vitro.. Objectives: We hypothesised that the spectral analysis of heart rate variability (HRV) might detect differences between amitriptyline, citalopram and reboxetine in their anticholinergic activities following a single peroral administration.. Methods: In this double-blind, cross-over study, amitriptyline (75 mg), citalopram (20 mg), reboxetine (4 mg) and placebo were randomly given at 1-week intervals to eight healthy male volunteers.

    Article Title: Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy.
    Article Snippet: Background: The antidepressant amitriptyline is used as an adjuvant in the treatment of chronic pain conditions.. Among its many actions, this drug also blocks ion channels, such as Na channels.. Preliminary animal studies suggested that amitriptyline would be a longer-lasting local anesthetic than bupivacaine, with potentially fewer side effects.

    Article Title: Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea
    Article Snippet: Amitriptyline hydrochloride (AMT) (Lundbeck AG, Opficon, Switzerland), orphenadrine citrate (ORP) (Meda Pharma GmbH, Vienna, Austria), and tramadol hydrochloride (TRM) (Ratiopharm GmbH, Ulm, Germany) were obtained as pharmaceutical preparation.

    Article Title: Analgesic effect of amitriptyline in chronic tension-type headache is not directly related to serotonin reuptake inhibition.
    Article Snippet: The tricyclic antidepressant amitriptyline is the only documented and most widely used prophylactic drug for chronic tension-type headache (CTTH).. However, it is not fully clarified whether the serotonin (5-HT) reuptake inhibition plays a major role for the analgesic effect of amitriptyline.. To explore the importance of 5-HT reuptake inhibition for mechanism of action of the analgesic effect of amitriptyline we investigated platelet 5-HT levels during preventive treatment of CTTH with amitriptyline, the selective serotonin reuptake inhibitor citalopram, and placebo.

    Capsules:

    Article Title: Postamputation pain and sensory changes in treatment-naive patients: characteristics and responses to treatment with tramadol, amitriptyline, and placebo.
    Article Snippet: Background: Pain after amputation is common but difficult to treat, and few controlled treatment studies exist.. Methods: In the current study, 94 treatment-naive posttraumatic limb amputees with phantom pain (intensity: mean visual analog scale score [0–100], 40 [95% confidence interval, 38–41]) were randomly assigned to receive individually titrated doses of tramadol, placebo (double-blind comparison), or amitriptyline (open comparison) for 1 month.. Nonresponders were crossed over to the alternative active treatment.



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    Antidepressant activity of BP (50, 100, and 200 mg/kg p.o.) was evaluated in FST ( A ), TST ( B ), and the mechanism of action of BP with inhibitors in the TST ( C ). The reference drug was 25 mg/kg p.o. <t>amitriptyline</t> <t>(AMT).</t> The results of all experimental groups are reported as the mean values (±SEM) (n = 8). Data were analyzed using a one-way analysis of variance (ANOVA) followed by Tukey post hoc tests. In the FST: a p < 0.05 vs. the vehicle group, and b p < 0.05 vs. the BP group at the dose of 50 mg/kg. In the TST: a p < 0.0001 vs. the vehicle group. In C: a p = 0.0090 vs. the vehicle group.
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    Antidepressant activity of BP (50, 100, and 200 mg/kg p.o.) was evaluated in FST ( A ), TST ( B ), and the mechanism of action of BP with inhibitors in the TST ( C ). The reference drug was 25 mg/kg p.o. <t>amitriptyline</t> <t>(AMT).</t> The results of all experimental groups are reported as the mean values (±SEM) (n = 8). Data were analyzed using a one-way analysis of variance (ANOVA) followed by Tukey post hoc tests. In the FST: a p < 0.05 vs. the vehicle group, and b p < 0.05 vs. the BP group at the dose of 50 mg/kg. In the TST: a p < 0.0001 vs. the vehicle group. In C: a p = 0.0090 vs. the vehicle group.
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    Image Search Results


    Antidepressant activity of BP (50, 100, and 200 mg/kg p.o.) was evaluated in FST ( A ), TST ( B ), and the mechanism of action of BP with inhibitors in the TST ( C ). The reference drug was 25 mg/kg p.o. amitriptyline (AMT). The results of all experimental groups are reported as the mean values (±SEM) (n = 8). Data were analyzed using a one-way analysis of variance (ANOVA) followed by Tukey post hoc tests. In the FST: a p < 0.05 vs. the vehicle group, and b p < 0.05 vs. the BP group at the dose of 50 mg/kg. In the TST: a p < 0.0001 vs. the vehicle group. In C: a p = 0.0090 vs. the vehicle group.

    Journal: Pharmaceuticals

    Article Title: Antidepressant-Like Effects of n -Butylidenephthalide Using In Vivo and In Silico Approaches

    doi: 10.3390/ph19020242

    Figure Lengend Snippet: Antidepressant activity of BP (50, 100, and 200 mg/kg p.o.) was evaluated in FST ( A ), TST ( B ), and the mechanism of action of BP with inhibitors in the TST ( C ). The reference drug was 25 mg/kg p.o. amitriptyline (AMT). The results of all experimental groups are reported as the mean values (±SEM) (n = 8). Data were analyzed using a one-way analysis of variance (ANOVA) followed by Tukey post hoc tests. In the FST: a p < 0.05 vs. the vehicle group, and b p < 0.05 vs. the BP group at the dose of 50 mg/kg. In the TST: a p < 0.0001 vs. the vehicle group. In C: a p = 0.0090 vs. the vehicle group.

    Article Snippet: n-Butylidenephthalide (BP) (95% purity) was from Santa Cruz Biotechnology (Santa Cruz, CA, USA); dimethyl sulfoxide (DMSO), TPA (12-O-tetradecanoylphorbol-13-acetate), pentylenetetrazol, pentobarbital, ketanserin, prazosin, and reserpine (RES) were obtained from Sigma-Aldrich (St. Louis, MO, USA); and amitriptyline (AMT) was from Cayman Chemical (Ann Arbor, MI, USA).

    Techniques: Activity Assay

    Effect of BP in the Novelty-Suppressed Feeding Test. The parameters evaluated were ( A ) latency time, ( B ) time spent eating, and ( C ) amount of food consumed. The abbreviations of AMT and BP correspond to amitriptyline (positive) and butylidenephthalide, respectively. The results are reported with the mean ± standard error mean (SEM) (n = 6–8). All data were analyzed using a one-way analysis of variance (ANOVA) followed by Dunnett post hoc tests. The “a” letter means statistical difference ( p < 0.05) versus the vehicle group.

    Journal: Pharmaceuticals

    Article Title: Antidepressant-Like Effects of n -Butylidenephthalide Using In Vivo and In Silico Approaches

    doi: 10.3390/ph19020242

    Figure Lengend Snippet: Effect of BP in the Novelty-Suppressed Feeding Test. The parameters evaluated were ( A ) latency time, ( B ) time spent eating, and ( C ) amount of food consumed. The abbreviations of AMT and BP correspond to amitriptyline (positive) and butylidenephthalide, respectively. The results are reported with the mean ± standard error mean (SEM) (n = 6–8). All data were analyzed using a one-way analysis of variance (ANOVA) followed by Dunnett post hoc tests. The “a” letter means statistical difference ( p < 0.05) versus the vehicle group.

    Article Snippet: n-Butylidenephthalide (BP) (95% purity) was from Santa Cruz Biotechnology (Santa Cruz, CA, USA); dimethyl sulfoxide (DMSO), TPA (12-O-tetradecanoylphorbol-13-acetate), pentylenetetrazol, pentobarbital, ketanserin, prazosin, and reserpine (RES) were obtained from Sigma-Aldrich (St. Louis, MO, USA); and amitriptyline (AMT) was from Cayman Chemical (Ann Arbor, MI, USA).

    Techniques:

    Behavioral tests of the reserpine-induced chronic depression model. The figures ( A – D ) correspond to the TST, FST, ECT, and rotarod tests, respectively. The abbreviations V, RS, BP, and AMT correspond to vehicle, reserpine, butylidenephthalide (BP), and amitriptyline, respectively. The results are reported with the mean ± standard error of the mean (SEM) (n = 10). Data were analyzed using a one-way analysis of variance (ANOVA) followed by Tukey post hoc tests. The “a” letter means statistical difference ( p < 0.05) versus the vehicle group not treated with reserpine, “b” means statistical difference versus the vehicle group pretreated with reserpine ( p < 0.05), and “c” means statistical difference versus the AMT group ( p < 0.05).

    Journal: Pharmaceuticals

    Article Title: Antidepressant-Like Effects of n -Butylidenephthalide Using In Vivo and In Silico Approaches

    doi: 10.3390/ph19020242

    Figure Lengend Snippet: Behavioral tests of the reserpine-induced chronic depression model. The figures ( A – D ) correspond to the TST, FST, ECT, and rotarod tests, respectively. The abbreviations V, RS, BP, and AMT correspond to vehicle, reserpine, butylidenephthalide (BP), and amitriptyline, respectively. The results are reported with the mean ± standard error of the mean (SEM) (n = 10). Data were analyzed using a one-way analysis of variance (ANOVA) followed by Tukey post hoc tests. The “a” letter means statistical difference ( p < 0.05) versus the vehicle group not treated with reserpine, “b” means statistical difference versus the vehicle group pretreated with reserpine ( p < 0.05), and “c” means statistical difference versus the AMT group ( p < 0.05).

    Article Snippet: n-Butylidenephthalide (BP) (95% purity) was from Santa Cruz Biotechnology (Santa Cruz, CA, USA); dimethyl sulfoxide (DMSO), TPA (12-O-tetradecanoylphorbol-13-acetate), pentylenetetrazol, pentobarbital, ketanserin, prazosin, and reserpine (RES) were obtained from Sigma-Aldrich (St. Louis, MO, USA); and amitriptyline (AMT) was from Cayman Chemical (Ann Arbor, MI, USA).

    Techniques:

    Data of four APIs and tentatively identified metabolites. If no CCS values are provided, the ion abundance was too low for accurate CCS determination

    Journal: Environmental Science and Pollution Research International

    Article Title: Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea

    doi: 10.1007/s11356-024-32379-x

    Figure Lengend Snippet: Data of four APIs and tentatively identified metabolites. If no CCS values are provided, the ion abundance was too low for accurate CCS determination

    Article Snippet: Amitriptyline hydrochloride (AMT) (Lundbeck AG, Opficon, Switzerland), orphenadrine citrate (ORP) (Meda Pharma GmbH, Vienna, Austria), and tramadol hydrochloride (TRM) (Ratiopharm GmbH, Ulm, Germany) were obtained as pharmaceutical preparation.

    Techniques: