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n n diisopropylethylamine dipea  (BOC Sciences)


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    Structured Review

    BOC Sciences n n diisopropylethylamine dipea
    N N Diisopropylethylamine Dipea, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 92/100, based on 13 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/71/Formic+acid/pmc04529353-70-4-3
    Average 92 stars, based on 13 article reviews
    n n diisopropylethylamine dipea - by Bioz Stars, 2026-10
    92/100 stars

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    Related Articles

    High Performance Liquid Chromatography:

    Article Title: Towards improved characterisation of complex polyethylene glycol excipients using supercritical fluid chromatography-evaporative light scattering detection-mass spectrometry and comparison with size exclusion chromatography-triple detection array.
    Article Snippet: The application of supercritical fluid chromatography (SFC) coupled to an evaporative light scattering detector (ELSD) and mass spectrometer (MS) was evaluated for the characterisation of three analogues of functionalised polyethylene glycol (PEG) 20 0 0 (m-PEG-OH, m-PEG-cm and cm-PEG-cm (where m = OCH 3 and cm = OCH 2 COOH)).. These polymers are common excipients in drug product formulations for pharmaceuticals as they help provide the desired pharmacokinetic profile for successful drug delivery.. A SFC-ELSD-MS method was developed which was selective to all three polymers, and allowed visualisation of these low UV chromophore materials.

    other:

    Article Title: Oxalobacter formigenes produces metabolites and lipids undetectable in oxalotrophic Bifidobacterium animalis.
    Article Snippet: Introduction In the search for new potential therapies for pathologies of oxalate, such as kidney stone disease and primary hyperoxaluria, the intestinal microbiome has generated significant interest.. Resident oxalate-degrading bacteria inhabit the gastrointestinal tract and reduce absorption of dietary oxalate, thereby potentially lowering the potency of oxalate as a risk factor for kidney stone formation.. Although several species of bacteria have been shown to degrade oxalate, select strains of Oxalobacter formigenes (O. formigenes) have thus far demonstrated the unique ability among oxalotrophs to initiate a net intestinal oxalate secretion into the lumen from the bloodstream, allowing them to feed on both dietary and endogenous metabolic oxalate.

    Article Title: Proteomic, Metabolomic, and Lipidomic Analyses of Lung Tissue Exposed to Mustard Gas
    Article Snippet: A working stock solution was prepared by combining the following volumes of each internal standard stock into a single vial containing 4715 µL of Fisher Optima gold label water with 0.1% formic acid (final volume 5000 µL): d3-creatine (10 µL), d10-leucine (10 µL), d3-L-tryptophan (10 µL), 13 C6-citric acid (20 µL), 13 C11-tryptophan (100 µL), 13 C6-leucine (10 µL), 13 C6-L-phenylalanine (10 µL), T-BOC-L-tert-leucine (10 µL), and T-BOC-L-aspartic acid (5 µL).

    Article Title: Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs
    Article Snippet: For monitoring metabolite extraction, 20 µL of metabolite internal standard mixture containing L-leucine-D10 (4 µg/mL), L-tryptophan-2,3,3-D3 (40 µg/mL), (4 µg/mL), L-tyrosine-13C6 (4 µg/mL), caffeine-D3 (4 µg/mL), succinic acid-2,3,3,3-D4 (4 µg/mL), L-leucine-13C6 (4 µg/mL), L-phenylalanine-13C6 (4 µg/mL), N-BOC-L-tert-leucine (4 µg/mL), and N-BOC-L-aspartic acid (4 µg/mL) in 0.1% formic acid in water was added to CSF prior to protein precipitation.

    Injection:

    Article Title: Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs
    Article Snippet: .. The dried sample was reconstituted in 0.1% formic acid in water (50 µL) containing injection standards including BOC-L-tyrosine (2 µg/mL), BOC-L-tryptophan (2 µg/mL), and BOC-D-phenylalanine (2 µg/mL). ..

    Article Title: Antibiotics Effects on the Fecal Metabolome in Preterm Infants
    Article Snippet: .. Samples were reconstituted with 25 µL of 0.1% formic acid containing injection standards (BOC-L-Tyrosine, BOC-L-Tryptophan, BOC-D-Phenylalanine), vortex mixed, and incubated at 4 °C for 10–15 min, followed by centrifugation at 20,000× g . The reconstituted samples were then transferred into LC-vials. .. Global metabolomics analysis was conducted using a Thermo Q-Exactive Orbitrap mass spectrometer with Dionex ultra high performance liquid chromatography (UHPLC) and autosampler [ ] (ThermoFisherScientific).

    Incubation:

    Article Title: Antibiotics Effects on the Fecal Metabolome in Preterm Infants
    Article Snippet: .. Samples were reconstituted with 25 µL of 0.1% formic acid containing injection standards (BOC-L-Tyrosine, BOC-L-Tryptophan, BOC-D-Phenylalanine), vortex mixed, and incubated at 4 °C for 10–15 min, followed by centrifugation at 20,000× g . The reconstituted samples were then transferred into LC-vials. .. Global metabolomics analysis was conducted using a Thermo Q-Exactive Orbitrap mass spectrometer with Dionex ultra high performance liquid chromatography (UHPLC) and autosampler [ ] (ThermoFisherScientific).

    Centrifugation:

    Article Title: Antibiotics Effects on the Fecal Metabolome in Preterm Infants
    Article Snippet: .. Samples were reconstituted with 25 µL of 0.1% formic acid containing injection standards (BOC-L-Tyrosine, BOC-L-Tryptophan, BOC-D-Phenylalanine), vortex mixed, and incubated at 4 °C for 10–15 min, followed by centrifugation at 20,000× g . The reconstituted samples were then transferred into LC-vials. .. Global metabolomics analysis was conducted using a Thermo Q-Exactive Orbitrap mass spectrometer with Dionex ultra high performance liquid chromatography (UHPLC) and autosampler [ ] (ThermoFisherScientific).



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    Image Search Results


    IC 50 values determined for the selected complexes.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

    doi: 10.1080/14756366.2026.2742455

    Figure Lengend Snippet: IC 50 values determined for the selected complexes.

    Article Snippet: Three human malignant melanoma cell lines, A-375 (CRL-1619 , American Type Culture Collection, Manassas, VA, USA), SK-MEL-28 (HTB-71 , American Type Culture Collection, Manassas, VA, USA), and G-361 (CRL-1424 , American Type Culture Collection, Manassas, VA, USA), were used in this study.

    Techniques:

    The results of mRNA gene expression analysis in SK-MEL-28 and A-375 cells treated with Cu(b-TSC) 2 , and in G-361 cells treated with Pd(dm-TSC-pCl) 2 for 48 h at concentrations corresponding to the IC 50 value. The results are expressed as relative quantification (RQ) values and presented as means. The mean RQ values are illustrated using a colour scale. The control was considered the representative reference sample for relative gene expression analysis. B-ACT and RNA18SN5 were selected as reference genes.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

    doi: 10.1080/14756366.2026.2742455

    Figure Lengend Snippet: The results of mRNA gene expression analysis in SK-MEL-28 and A-375 cells treated with Cu(b-TSC) 2 , and in G-361 cells treated with Pd(dm-TSC-pCl) 2 for 48 h at concentrations corresponding to the IC 50 value. The results are expressed as relative quantification (RQ) values and presented as means. The mean RQ values are illustrated using a colour scale. The control was considered the representative reference sample for relative gene expression analysis. B-ACT and RNA18SN5 were selected as reference genes.

    Article Snippet: Three human malignant melanoma cell lines, A-375 (CRL-1619 , American Type Culture Collection, Manassas, VA, USA), SK-MEL-28 (HTB-71 , American Type Culture Collection, Manassas, VA, USA), and G-361 (CRL-1424 , American Type Culture Collection, Manassas, VA, USA), were used in this study.

    Techniques: Gene Expression, Analysis, Quantitative Proteomics, Control

    Cell cycle analysis of melanoma cells following treatment with selected complexes, compared to untreated controls. ( A ) Quantitative distribution of cell cycle phases (SubG1, G1, S, and G2/M) in A-375 and SK-MEL-28 cells treated with Cu(b-TSC) 2 , and G-361 cells treated with Pd(dm-TSC-pCl) 2 at their respective IC 50 concentrations. ( B ) Representative DNA content histograms for each condition, illustrating the distribution of cell populations in SubG1 (M1), G1 (M2), S (M3), and G2/M (M4) phases; the SubG1 fraction reflects DNA fragmentation associated with apoptosis.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

    doi: 10.1080/14756366.2026.2742455

    Figure Lengend Snippet: Cell cycle analysis of melanoma cells following treatment with selected complexes, compared to untreated controls. ( A ) Quantitative distribution of cell cycle phases (SubG1, G1, S, and G2/M) in A-375 and SK-MEL-28 cells treated with Cu(b-TSC) 2 , and G-361 cells treated with Pd(dm-TSC-pCl) 2 at their respective IC 50 concentrations. ( B ) Representative DNA content histograms for each condition, illustrating the distribution of cell populations in SubG1 (M1), G1 (M2), S (M3), and G2/M (M4) phases; the SubG1 fraction reflects DNA fragmentation associated with apoptosis.

    Article Snippet: Three human malignant melanoma cell lines, A-375 (CRL-1619 , American Type Culture Collection, Manassas, VA, USA), SK-MEL-28 (HTB-71 , American Type Culture Collection, Manassas, VA, USA), and G-361 (CRL-1424 , American Type Culture Collection, Manassas, VA, USA), were used in this study.

    Techniques: Cell Cycle Assay

    Apoptosis analysis of melanoma cells following treatment with selected complexes, compared to untreated controls. ( A ) Quantitative assessment of A-375 and SK-MEL-28 cells treated with Cu(b-TSC) 2 , and G-361 cells treated with Pd(dm-TSC-pCl) 2 at their respective IC 50 concentrations. Cells were stained with Annexin V-CF488A, Hoechst 33342, and propidium iodide (PI) and analysed using the NucleoCounter ® NC-3000 ™ image cytometer. The bar graph represents the percentage of live (Annexin V-negative/PI-negative), early apoptotic (Annexin V-positive/PI-negative), late apoptotic (Annexin V-positive/PI-positive), and necrotic cells. (B) Representative scatter plots for each condition, illustrating the distribution of cell populations divided into four quadrants: lower left (Q1ll), viable cells; lower right (Q1lr), early apoptotic cells; upper right (Q1ur), late apoptotic cells; and upper left (Q1ul), necrotic cells.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

    doi: 10.1080/14756366.2026.2742455

    Figure Lengend Snippet: Apoptosis analysis of melanoma cells following treatment with selected complexes, compared to untreated controls. ( A ) Quantitative assessment of A-375 and SK-MEL-28 cells treated with Cu(b-TSC) 2 , and G-361 cells treated with Pd(dm-TSC-pCl) 2 at their respective IC 50 concentrations. Cells were stained with Annexin V-CF488A, Hoechst 33342, and propidium iodide (PI) and analysed using the NucleoCounter ® NC-3000 ™ image cytometer. The bar graph represents the percentage of live (Annexin V-negative/PI-negative), early apoptotic (Annexin V-positive/PI-negative), late apoptotic (Annexin V-positive/PI-positive), and necrotic cells. (B) Representative scatter plots for each condition, illustrating the distribution of cell populations divided into four quadrants: lower left (Q1ll), viable cells; lower right (Q1lr), early apoptotic cells; upper right (Q1ur), late apoptotic cells; and upper left (Q1ul), necrotic cells.

    Article Snippet: Three human malignant melanoma cell lines, A-375 (CRL-1619 , American Type Culture Collection, Manassas, VA, USA), SK-MEL-28 (HTB-71 , American Type Culture Collection, Manassas, VA, USA), and G-361 (CRL-1424 , American Type Culture Collection, Manassas, VA, USA), were used in this study.

    Techniques: Analysis, Staining, Cytometry

    IC 50 values determined for Cu(b-TSC) 2 and vemurafenib on parental and vemurafenib-resistant  SK-MEL-28  and A-375 cells.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

    doi: 10.1080/14756366.2026.2742455

    Figure Lengend Snippet: IC 50 values determined for Cu(b-TSC) 2 and vemurafenib on parental and vemurafenib-resistant SK-MEL-28 and A-375 cells.

    Article Snippet: Three human malignant melanoma cell lines, A-375 (CRL-1619 , American Type Culture Collection, Manassas, VA, USA), SK-MEL-28 (HTB-71 , American Type Culture Collection, Manassas, VA, USA), and G-361 (CRL-1424 , American Type Culture Collection, Manassas, VA, USA), were used in this study.

    Techniques:

    Exploratory plots of log(IC 50 ) against the calculated logP o/w , qPSA NOS /SASA, logS, and E solv descriptors for the investigated Cu(II) complexes. Linear regression lines and the corresponding coefficients of determination (R 2 ) are shown.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

    doi: 10.1080/14756366.2026.2742455

    Figure Lengend Snippet: Exploratory plots of log(IC 50 ) against the calculated logP o/w , qPSA NOS /SASA, logS, and E solv descriptors for the investigated Cu(II) complexes. Linear regression lines and the corresponding coefficients of determination (R 2 ) are shown.

    Article Snippet: Three human malignant melanoma cell lines, A-375 (CRL-1619 , American Type Culture Collection, Manassas, VA, USA), SK-MEL-28 (HTB-71 , American Type Culture Collection, Manassas, VA, USA), and G-361 (CRL-1424 , American Type Culture Collection, Manassas, VA, USA), were used in this study.

    Techniques:

    Exploratory plots of log(IC 50 ) against the calculated logP o/w , qPSA NOS /SASA, logS, and E solv descriptors for the investigated Pd(II) complexes. Linear regression lines and the corresponding coefficients of determination (R 2 ) are shown.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

    doi: 10.1080/14756366.2026.2742455

    Figure Lengend Snippet: Exploratory plots of log(IC 50 ) against the calculated logP o/w , qPSA NOS /SASA, logS, and E solv descriptors for the investigated Pd(II) complexes. Linear regression lines and the corresponding coefficients of determination (R 2 ) are shown.

    Article Snippet: Three human malignant melanoma cell lines, A-375 (CRL-1619 , American Type Culture Collection, Manassas, VA, USA), SK-MEL-28 (HTB-71 , American Type Culture Collection, Manassas, VA, USA), and G-361 (CRL-1424 , American Type Culture Collection, Manassas, VA, USA), were used in this study.

    Techniques:

    Cell viability of SK-MEL-28 cancer cells after 48 h of incubation with the studied compounds at 10 µM. The three sections represent 3,4-dimethoxybenzylidene-, 3,4-dichlorobenzylidene-, and 4-bromobenzylidene- derivatives, respectively. Green, blue, and orange bars represent free organic ligands, Cu(II) complexes, and Pd(II) complexes, respectively.

    Journal: Journal of Enzyme Inhibition and Medicinal Chemistry

    Article Title: Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

    doi: 10.1080/14756366.2026.2742455

    Figure Lengend Snippet: Cell viability of SK-MEL-28 cancer cells after 48 h of incubation with the studied compounds at 10 µM. The three sections represent 3,4-dimethoxybenzylidene-, 3,4-dichlorobenzylidene-, and 4-bromobenzylidene- derivatives, respectively. Green, blue, and orange bars represent free organic ligands, Cu(II) complexes, and Pd(II) complexes, respectively.

    Article Snippet: Three human malignant melanoma cell lines, A-375 (CRL-1619 , American Type Culture Collection, Manassas, VA, USA), SK-MEL-28 (HTB-71 , American Type Culture Collection, Manassas, VA, USA), and G-361 (CRL-1424 , American Type Culture Collection, Manassas, VA, USA), were used in this study.

    Techniques: Incubation