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pbpk software simcyp simulator (version 16)  (Simcyp)

 
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    Structured Review

    Simcyp pbpk software simcyp simulator (version 16)
    Summary input data for apatinib in <t> Simcyp </t> Simulator simulation
    Pbpk Software Simcyp Simulator (Version 16), supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/16+simulation+software/13+compartment+full+pbpk+model+simcyp++population+based+simulator+version+12+1/pmc08645681-87-8-10
    Average 90 stars, based on 1 article reviews
    pbpk software simcyp simulator (version 16) - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib"

    Article Title: Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib

    Journal: Frontiers in Pharmacology

    doi: 10.3389/fphar.2021.780937

    Summary input data for apatinib in  Simcyp  Simulator simulation
    Figure Legend Snippet: Summary input data for apatinib in Simcyp Simulator simulation

    Techniques Used: Molecular Weight, Permeability

    Related Articles

    Clinical Proteomics:

    Article Title: Precision Medicine in Oncology: Imatinib Dosing in the Obese Cancer Population Using Virtual Clinical Trials.
    Article Snippet: .. The simulations of imatinib plasma profiles on adult cancer populations were performed using the PBPK modeling platform Simcyp Version 21 (Simcyp Ltd., a Certara company, Sheffield, UK). ..

    other:

    Article Title: Determination of Vatiquinone Drug‐Drug Interactions, as CYP450 Perpetrator and Victim, Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation
    Article Snippet: A PBPK model (Simcyp Simulator version 21, full model) was developed using parameters obtained from in vitro studies, in silico estimation and optimization, and two clinical studies.

    Article Title: Determination of Vatiquinone Drug-Drug Interactions, as CYP450 Perpetrator and Victim, Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation.
    Article Snippet: A PBPK model (Simcyp Simulator version 21, full model) was developed using parameters obtained from in vitro studies, in silico estimation and optimization,and two clinical studies.A venous blood dosing model best characterized vatiquinone lymphatic absorption.

    Article Title: A review of physiologically based pharmacokinetic modeling of renal drug disposition.
    Article Snippet: Recently, an Innovation and Quality Consortium effort (Heimbach et al, 2021) has also been conducted to summarize the industrial experience in applying PBPKmodeling (Simcyp V15) in RI where the AUC ratios of RI to healthy control were predicted within 2-fold of the observed ratios for >90% of all cases.

    Drug discovery:

    Article Title: A tutorial on physiologically based pharmacokinetic approaches in lactation research
    Article Snippet: .. A verified PBPK model in Simcyp simulator version 21 for efavirenz describing the CYP3A4‐ and CYP2B6‐mediated auto‐induction during multiple dosing was able to accurately predict efavirenz pharmacokinetics in African mothers at post‐partum with different CYP2B6 genotypes (516GG, GT, and TT). ..

    Software:

    Article Title: Mathematical Albumin Function for Neonates Undergoing Therapeutic Hypothermia in Comparison with Control Neonates
    Article Snippet: .. The developed HSA function of this study was compared to the existing HSA function in the available PBPK modeling software Simcyp (Simcyp simulator version 22, release 1, Sheffield, UK): HSA = 33.746 + 1.1287*log(PNA) (Simcyp function). .. This Simcyp function represents the general neonatal population, not specifically HIE cases.

    In Vitro:

    Article Title: 2024 Annual Meeting American College of Clinical Pharmacology®.
    Article Snippet: .. A combination of in vitro data and clinical PK data following single and multiple dosing of 70 mg QD lirafugratinib in cancer patients were used to develop the PBPK model using Simcyp® v21 simulator. .. Pharmacokinetics (PK) obtained from the lirafugratinib/itraconazole clinical DDI study and patient study (additional doses of 20 – 100mg QD or BID) were used to verify the PBPK model.



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    Image Search Results


    Summary input data for apatinib in  Simcyp  Simulator simulation

    Journal: Frontiers in Pharmacology

    Article Title: Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib

    doi: 10.3389/fphar.2021.780937

    Figure Lengend Snippet: Summary input data for apatinib in Simcyp Simulator simulation

    Article Snippet: All simulations were conducted using a commercially available PBPK software, Simcyp Simulator (version 16; Simcyp Limited, Sheffield, UK).

    Techniques: Molecular Weight, Permeability