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Simcyp simulator software version 16 release 1
Simulator Software Version 16 Release 1, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/16+simulation+software/simulator+version+15/pm30300922-149-9-15
Average 90 stars, based on 1 article reviews
simulator software version 16 release 1 - by Bioz Stars, 2026-11
90/100 stars

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Related Articles

Construct:

Article Title: PBPK modeling to predict drug‐drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction
Article Snippet: To assess the prediction accuracy of the PBPK modeling platform (Simcyp Simulator version 15.1) with respect to the induction of CYP3A4‐mediated DDIs, 20 clinical studies were identified for this analysis.

Article Title: Application of a Physiologically Based Pharmacokinetic Model to Predict Cefazolin and Cefuroxime Disposition in Obese Pregnant Women Undergoing Caesarean Section
Article Snippet: An existing compound file for cefuroxime has been developed previously by Hsu et al. using the Simcyp simulator version 12.1 in lean non–pregnant subjects [ ].

Article Title: Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex
Article Snippet: PBPK models for VPA IR and ER formulations were constructed using Simcyp Simulator (Version 15).

Article Title: Evaluation of the drug–drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach
Article Snippet: Available information on the metabolism and PK of brigatinib was utilized to develop the PBPK model for brigatinib using the Simcyp Population‐based Simulator versions 15 and 17.

Article Title: Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs
Article Snippet: PBPK models were constructed in the Simcyp Simulator (V16 release 1) using the workflow illustrated in Figure .

Article Title: Advancements in Virtual Bioequivalence: A Systematic Review of Computational Methods and Regulatory Perspectives in the Pharmaceutical Industry
Article Snippet: Xiao, Q. et al. [ ], 2015 , Cochrane Library , Repaglinide and pioglitazone , Antidiabetic , SimCYP ® version 14.1.

Protein Binding:

Article Title: PBPK modeling to predict drug‐drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction
Article Snippet: To assess the prediction accuracy of the PBPK modeling platform (Simcyp Simulator version 15.1) with respect to the induction of CYP3A4‐mediated DDIs, 20 clinical studies were identified for this analysis.

Article Title: Application of a Physiologically Based Pharmacokinetic Model to Predict Cefazolin and Cefuroxime Disposition in Obese Pregnant Women Undergoing Caesarean Section
Article Snippet: An existing compound file for cefuroxime has been developed previously by Hsu et al. using the Simcyp simulator version 12.1 in lean non–pregnant subjects [ ].

Article Title: Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex
Article Snippet: PBPK models for VPA IR and ER formulations were constructed using Simcyp Simulator (Version 15).

Article Title: Evaluation of the drug–drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach
Article Snippet: Available information on the metabolism and PK of brigatinib was utilized to develop the PBPK model for brigatinib using the Simcyp Population‐based Simulator versions 15 and 17.

Article Title: Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs
Article Snippet: PBPK models were constructed in the Simcyp Simulator (V16 release 1) using the workflow illustrated in Figure .

Article Title: Advancements in Virtual Bioequivalence: A Systematic Review of Computational Methods and Regulatory Perspectives in the Pharmaceutical Industry
Article Snippet: Xiao, Q. et al. [ ], 2015 , Cochrane Library , Repaglinide and pioglitazone , Antidiabetic , SimCYP ® version 14.1.



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Summary input data for apatinib in <t> Simcyp </t> Simulator simulation
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Summary input data for apatinib in  Simcyp  Simulator simulation

Journal: Frontiers in Pharmacology

Article Title: Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib

doi: 10.3389/fphar.2021.780937

Figure Lengend Snippet: Summary input data for apatinib in Simcyp Simulator simulation

Article Snippet: All simulations were conducted using a commercially available PBPK software, Simcyp Simulator (version 16; Simcyp Limited, Sheffield, UK).

Techniques: Molecular Weight, Permeability