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Image Search Results
Journal: Journal of Cellular Biochemistry
Article Title: Targeting PKC-Mediated Signal Transduction Pathways Using Enzastaurin to Promote Apoptosis in Acute Myeloid Leukemia-Derived Cell Lines and Blast Cells
doi: 10.1002/jcb.23090
Figure Lengend Snippet: PKC β and PKC δ expression is generally elevated IN AML blast cells compared to normal CD34+ bone marrow cells. Real-time PCR was performed as described in Materials and Methods section. Expression of PRKCA (PKC α), PRKCB (PKC β), PRKCD (PKC δ), and PRKCE (PKC ε) genes are presented as relative to 100 copies of b2M for AML-derived cell lines (A) and as relative to 100 copies of ABL1for CD34+ cells derived from bone marrow from normal donors (N = 6) and blast cells derived from AML patients (N = 75; B). P values were derived as described in Materials and Methods section. Statistically significant differences from expression in normal bone marrow cells (P < 0.05) are marked by “*.”
Article Snippet: Statistical analysis was performed with Sigma Stat computer software (SSPS, Chicago, IL). table ft1 table-wrap mode="anchored" t5 TABLE II caption a7 Common name Symbol Chromosome location ABI assay ID PKC α PRKCA 17q22-q23.2 Hs00176973_m1 PKC β PPP2R1B 16p11.2
Techniques: Expressing, Real-time Polymerase Chain Reaction, Derivative Assay