HY-15296A Search Results


cabergoline  (MedChemExpress)
94
MedChemExpress cabergoline
Cholesterol promoted the resistance of MMQ cells to DAs. ( A ) Cell viability assays of MMQ cells after treatment with CHO/Mβ-CD and <t>cabergoline</t> alone or in combination. ( B )-( C ) Flow cytometry analysis of MMQ cell apoptosis after treatment with CHO/Mβ-CD and cabergoline alone or in combination. ( D )-( E ) Detection of cholesterol and triglyceride levels in the peripheral blood of nude mice after they were fed a high-fat diet or control diet for six weeks. ( F ) Weights of the nude mice prior to tumor resection. ( G ) Images of tumor xenografts in nude mice after being exposed to different diets and drugs ( H -( I ). Weights and volumes of the tumor xenografts. * P < 0.05, *** P < 0.001, **** P < 0.0001
Cabergoline, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Cholesterol promoted the resistance of MMQ cells to DAs. ( A ) Cell viability assays of MMQ cells after treatment with CHO/Mβ-CD and cabergoline alone or in combination. ( B )-( C ) Flow cytometry analysis of MMQ cell apoptosis after treatment with CHO/Mβ-CD and cabergoline alone or in combination. ( D )-( E ) Detection of cholesterol and triglyceride levels in the peripheral blood of nude mice after they were fed a high-fat diet or control diet for six weeks. ( F ) Weights of the nude mice prior to tumor resection. ( G ) Images of tumor xenografts in nude mice after being exposed to different diets and drugs ( H -( I ). Weights and volumes of the tumor xenografts. * P < 0.05, *** P < 0.001, **** P < 0.0001

Journal: Acta Neuropathologica Communications

Article Title: Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance

doi: 10.1186/s40478-025-01986-1

Figure Lengend Snippet: Cholesterol promoted the resistance of MMQ cells to DAs. ( A ) Cell viability assays of MMQ cells after treatment with CHO/Mβ-CD and cabergoline alone or in combination. ( B )-( C ) Flow cytometry analysis of MMQ cell apoptosis after treatment with CHO/Mβ-CD and cabergoline alone or in combination. ( D )-( E ) Detection of cholesterol and triglyceride levels in the peripheral blood of nude mice after they were fed a high-fat diet or control diet for six weeks. ( F ) Weights of the nude mice prior to tumor resection. ( G ) Images of tumor xenografts in nude mice after being exposed to different diets and drugs ( H -( I ). Weights and volumes of the tumor xenografts. * P < 0.05, *** P < 0.001, **** P < 0.0001

Article Snippet: DMSO (HY-Y0320, MedChemExpress) and Mβ-CD (C4555, Sigma Aldrich) were used as vehicle for cabergoline and cholesterol, respectively.

Techniques: Flow Cytometry, Control

Stress granules mediated the cholesterol-regulated reduction in DRD2 localization on the cell membrane. ( A ) USP10 can inhibit the assembly of stress granules, according to a previous study. ( B ) Overexpression of USP10 in MMQ cells and its effect on DRD2 protein levels. ( C ) Fluorescence staining of stress granules with TASG in USP10 Mock and USP10 OE MMQ cells. ( D - E ) Western blot analysis of the cell membrane proteins of USP10 Mock and USP10 OE MMQ cells. ( F - G ) Fluorescence staining of DRD2 in USP10 Mock and USP10 OE MMQ cells. ( H-I ) CCK-8 results of USP10 Mock and USP10 OE MMQ cells treated with CHO/Mβ-CD and cabergoline alone or in combination. ( J ) Fluorescence staining of stress granules with TASG in MMQ cells. ( K ) Western blot analysis of the levels of cell membrane proteins in MMQ cells. ( L ) CCK-8 results for MMQ-treated cells. *** P < 0.001, **** P < 0.0001. Scale bar: 5 μm

Journal: Acta Neuropathologica Communications

Article Title: Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance

doi: 10.1186/s40478-025-01986-1

Figure Lengend Snippet: Stress granules mediated the cholesterol-regulated reduction in DRD2 localization on the cell membrane. ( A ) USP10 can inhibit the assembly of stress granules, according to a previous study. ( B ) Overexpression of USP10 in MMQ cells and its effect on DRD2 protein levels. ( C ) Fluorescence staining of stress granules with TASG in USP10 Mock and USP10 OE MMQ cells. ( D - E ) Western blot analysis of the cell membrane proteins of USP10 Mock and USP10 OE MMQ cells. ( F - G ) Fluorescence staining of DRD2 in USP10 Mock and USP10 OE MMQ cells. ( H-I ) CCK-8 results of USP10 Mock and USP10 OE MMQ cells treated with CHO/Mβ-CD and cabergoline alone or in combination. ( J ) Fluorescence staining of stress granules with TASG in MMQ cells. ( K ) Western blot analysis of the levels of cell membrane proteins in MMQ cells. ( L ) CCK-8 results for MMQ-treated cells. *** P < 0.001, **** P < 0.0001. Scale bar: 5 μm

Article Snippet: DMSO (HY-Y0320, MedChemExpress) and Mβ-CD (C4555, Sigma Aldrich) were used as vehicle for cabergoline and cholesterol, respectively.

Techniques: Membrane, Over Expression, Fluorescence, Staining, Western Blot, CCK-8 Assay