HY-132595 Search Results


mg 132  (MedChemExpress)
99
MedChemExpress mg 132
Mg 132, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(r)-mg-132  (MedChemExpress)
94
MedChemExpress (r)-mg-132
(R) Mg 132, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mg132  (MedChemExpress)
97
MedChemExpress mg132
(A) The ubiquitination level of LAMP1 treated with CQ (10 μM) and <t>MG132</t> (50 nM) before and after SVA infection. (B,C) Effect of CQ (50 μM) and MG132 (50 nM) on LAMP1 protein levels before and after SVA infection. (D,E) Effects of DLC alone or in combination with MG132 (50 nM) on LAMP1 protein levels after SVA infection. (F) Effect of DLC on the interaction between endogenous TRIM16 and Gal3 in SVA infected cells by Co-IP (After Gal protein was immunoprecipitated, Gal3 and TRIM16 proteins were respectively used for detection). (G,H) Colocalization changes of TRIM16 and Gal3 in cells with and without DLC (5 μM) after SVA infection (0.01MOI, 24 hpi) and quantitative analysis.(*p < 0.05, **p < 0.01, ***p < 0.001, n = 3).
Mg132, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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inclisiran  (MedChemExpress)
94
MedChemExpress inclisiran
A , Experimental workflow for characterising inflammatory and oxidative stress in VSMCs. B . PCSK9 protein abundance (log2 MS intensity) in observed (dark dots) and imputed (light dots) samples across conditions, with statistical comparisons shown. C , Knowledge-graph analysis of POVPC-induced gene expression changes; D , Pathway activation analysis comparing control (ethanol, grey), POVPC treatment (red) and PCSK9 knockdown <t>(Inclisiran,</t> blue) effects.
Inclisiran, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
inclisiran - by Bioz Stars, 2026-02
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26s proteasome inhibitor  (MedChemExpress)
90
MedChemExpress 26s proteasome inhibitor
Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + <t>MG132-treated</t> PANC-1 cells under hypoxic conditions ( n = 3).
26s Proteasome Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pmsf  (MedChemExpress)
98
MedChemExpress pmsf
Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + <t>MG132-treated</t> PANC-1 cells under hypoxic conditions ( n = 3).
Pmsf, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 98 stars, based on 1 article reviews
pmsf - by Bioz Stars, 2026-02
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necrostatin 1  (MedChemExpress)
99
MedChemExpress necrostatin 1
Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + <t>MG132-treated</t> PANC-1 cells under hypoxic conditions ( n = 3).
Necrostatin 1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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necrostatin 1 - by Bioz Stars, 2026-02
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teprasiran  (MedChemExpress)
N/A
Teprasiran sodium is a small interfering RNA that temporarily inhibits p53-mediated cell death that underlies acute kidney injury (AKI).
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Image Search Results


(A) The ubiquitination level of LAMP1 treated with CQ (10 μM) and MG132 (50 nM) before and after SVA infection. (B,C) Effect of CQ (50 μM) and MG132 (50 nM) on LAMP1 protein levels before and after SVA infection. (D,E) Effects of DLC alone or in combination with MG132 (50 nM) on LAMP1 protein levels after SVA infection. (F) Effect of DLC on the interaction between endogenous TRIM16 and Gal3 in SVA infected cells by Co-IP (After Gal protein was immunoprecipitated, Gal3 and TRIM16 proteins were respectively used for detection). (G,H) Colocalization changes of TRIM16 and Gal3 in cells with and without DLC (5 μM) after SVA infection (0.01MOI, 24 hpi) and quantitative analysis.(*p < 0.05, **p < 0.01, ***p < 0.001, n = 3).

Journal: PLOS Pathogens

Article Title: A novel SO 2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylation

doi: 10.1371/journal.ppat.1013932

Figure Lengend Snippet: (A) The ubiquitination level of LAMP1 treated with CQ (10 μM) and MG132 (50 nM) before and after SVA infection. (B,C) Effect of CQ (50 μM) and MG132 (50 nM) on LAMP1 protein levels before and after SVA infection. (D,E) Effects of DLC alone or in combination with MG132 (50 nM) on LAMP1 protein levels after SVA infection. (F) Effect of DLC on the interaction between endogenous TRIM16 and Gal3 in SVA infected cells by Co-IP (After Gal protein was immunoprecipitated, Gal3 and TRIM16 proteins were respectively used for detection). (G,H) Colocalization changes of TRIM16 and Gal3 in cells with and without DLC (5 μM) after SVA infection (0.01MOI, 24 hpi) and quantitative analysis.(*p < 0.05, **p < 0.01, ***p < 0.001, n = 3).

Article Snippet: Chemical reagents LAMP1, MG132 (HY-13259), chloroquine (CQ; HY-17589A), L-Aspartic acid β-hydroxamate (HY-134450), Stretavidin Agarose 6FF (HY-K0218A), were purchased from MedChemExpress; Lysosomal protein extraction kit(Best bio, BB-31452); Cytoplasmic protein extraction kit(Best bio, BB-3113); DLC, CIJ and BTD were synthesized by the research group of Baoxiang Zhao, College of Chemistry, Shandong University.

Techniques: Ubiquitin Proteomics, Infection, Co-Immunoprecipitation Assay, Immunoprecipitation

A , Experimental workflow for characterising inflammatory and oxidative stress in VSMCs. B . PCSK9 protein abundance (log2 MS intensity) in observed (dark dots) and imputed (light dots) samples across conditions, with statistical comparisons shown. C , Knowledge-graph analysis of POVPC-induced gene expression changes; D , Pathway activation analysis comparing control (ethanol, grey), POVPC treatment (red) and PCSK9 knockdown (Inclisiran, blue) effects.

Journal: medRxiv

Article Title: Spatially resolved proteomic signatures of atherosclerotic carotid artery disease

doi: 10.1101/2025.02.09.25321955

Figure Lengend Snippet: A , Experimental workflow for characterising inflammatory and oxidative stress in VSMCs. B . PCSK9 protein abundance (log2 MS intensity) in observed (dark dots) and imputed (light dots) samples across conditions, with statistical comparisons shown. C , Knowledge-graph analysis of POVPC-induced gene expression changes; D , Pathway activation analysis comparing control (ethanol, grey), POVPC treatment (red) and PCSK9 knockdown (Inclisiran, blue) effects.

Article Snippet: Subsequently, 25 nM Inclisiran (HY-132591, MedChemExpress) or 25 nM negative control siRNA (AM4614, Ambion) was introduced in SF&PRF medium using RNAiMAX (13778-150, Thermo Fisher).

Techniques: Expressing, Activation Assay, Control, Knockdown

A , Number of proteins quantified in cellular proteome (orange) and secretome (green) across experimental conditions. B , Principal component analysis of cellular proteome and secretome samples showing separation of treatment conditions. C-D , Volcano plots showing differentially expressed proteins (red dots, p < 0.05) in response to D, POVPC treatment and E, PCSK9 knockdown compared to controls (siNEG). E , Integrated knowledge graph analysis of proteins significantly upregulated upon PCSK9 knockdown with Inclisiran (red: upregulated, blue: downregulated).

Journal: medRxiv

Article Title: Spatially resolved proteomic signatures of atherosclerotic carotid artery disease

doi: 10.1101/2025.02.09.25321955

Figure Lengend Snippet: A , Number of proteins quantified in cellular proteome (orange) and secretome (green) across experimental conditions. B , Principal component analysis of cellular proteome and secretome samples showing separation of treatment conditions. C-D , Volcano plots showing differentially expressed proteins (red dots, p < 0.05) in response to D, POVPC treatment and E, PCSK9 knockdown compared to controls (siNEG). E , Integrated knowledge graph analysis of proteins significantly upregulated upon PCSK9 knockdown with Inclisiran (red: upregulated, blue: downregulated).

Article Snippet: Subsequently, 25 nM Inclisiran (HY-132591, MedChemExpress) or 25 nM negative control siRNA (AM4614, Ambion) was introduced in SF&PRF medium using RNAiMAX (13778-150, Thermo Fisher).

Techniques: Knockdown

Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions ( n = 3).

Journal: Frontiers in Pharmacology

Article Title: Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α

doi: 10.3389/fphar.2023.1138265

Figure Lengend Snippet: Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions ( n = 3).

Article Snippet: TQ (HY-D0803, MCE); GEM (HY-17026, MCE); dimethyl sulfoxide (Sigma); fetal bovine serum (GIBCO), RPMI-1640 medium (GIBCO); primary antibodies including anti-COL1A1 (67288-1-Ig, PROTEINTECH), anti-COL3A1 (22734-1-AP, PROTEINTECH), anti-COL5A1 (67604-1-Ig, PROTEINTECH), anti-HIF-1α (20960-1-AP, PROTEINTECH), anti-OH-HIF-1α (3434T, CST), anti-TGFβ1 (21898-1-AP, PROTEINTECH), anti-Smad2 (12570-1-AP, PROTEINTECH), anti-Smad3 (66516-1-Ig, PROTEINTECH); hTGFβ (HY-P70543, MCE); LY2157299 (HY-13226, MCE); PX-478 (HY-10231, MCE); 26S proteasome inhibitor (MG132) (HY-132598, MCE); CCK-8 kit (Biyuntian Institute of Biotechnology); TUNEL Kit (11684817910, Roche); Annexin V-FITC Apoptosis Detection Kit (AO 2001-02P-G, Tianjin Sanjian Biotechnology Co., Ltd.) were used in this study.

Techniques:

TQ and GEM affect cell apoptosis and motility in PC cells under hypoxic conditions. (A) Transwell (migration and invasion) of NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (B) Statistical analysis of Figure 6 (apoptosis analysis). (C) Statistical analysis of (A) (transwell migration). (D) Statistical analysis of (A) (transwell invasion). * p < 0.05 compared with NC; # p < 0.05 compared with TQ or GEM; and p < 0.05 compared with TQ + GEM ( n = 3).

Journal: Frontiers in Pharmacology

Article Title: Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α

doi: 10.3389/fphar.2023.1138265

Figure Lengend Snippet: TQ and GEM affect cell apoptosis and motility in PC cells under hypoxic conditions. (A) Transwell (migration and invasion) of NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (B) Statistical analysis of Figure 6 (apoptosis analysis). (C) Statistical analysis of (A) (transwell migration). (D) Statistical analysis of (A) (transwell invasion). * p < 0.05 compared with NC; # p < 0.05 compared with TQ or GEM; and p < 0.05 compared with TQ + GEM ( n = 3).

Article Snippet: TQ (HY-D0803, MCE); GEM (HY-17026, MCE); dimethyl sulfoxide (Sigma); fetal bovine serum (GIBCO), RPMI-1640 medium (GIBCO); primary antibodies including anti-COL1A1 (67288-1-Ig, PROTEINTECH), anti-COL3A1 (22734-1-AP, PROTEINTECH), anti-COL5A1 (67604-1-Ig, PROTEINTECH), anti-HIF-1α (20960-1-AP, PROTEINTECH), anti-OH-HIF-1α (3434T, CST), anti-TGFβ1 (21898-1-AP, PROTEINTECH), anti-Smad2 (12570-1-AP, PROTEINTECH), anti-Smad3 (66516-1-Ig, PROTEINTECH); hTGFβ (HY-P70543, MCE); LY2157299 (HY-13226, MCE); PX-478 (HY-10231, MCE); 26S proteasome inhibitor (MG132) (HY-132598, MCE); CCK-8 kit (Biyuntian Institute of Biotechnology); TUNEL Kit (11684817910, Roche); Annexin V-FITC Apoptosis Detection Kit (AO 2001-02P-G, Tianjin Sanjian Biotechnology Co., Ltd.) were used in this study.

Techniques: Migration

TQ might affect GEM sensitivity by regulating ECM production in PC cells under hypoxic conditions. (A) Western blot of HIF-1α in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (B) Western blot of ECM production-related proteins and TGFβ1 in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (C) Statistical analysis of (A , B) . * p < 0.05 compared with NC; # p < 0.05 compared with TQ or GEM; and p < 0.05 compared with TQ + GEM ( n = 3).

Journal: Frontiers in Pharmacology

Article Title: Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α

doi: 10.3389/fphar.2023.1138265

Figure Lengend Snippet: TQ might affect GEM sensitivity by regulating ECM production in PC cells under hypoxic conditions. (A) Western blot of HIF-1α in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (B) Western blot of ECM production-related proteins and TGFβ1 in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (C) Statistical analysis of (A , B) . * p < 0.05 compared with NC; # p < 0.05 compared with TQ or GEM; and p < 0.05 compared with TQ + GEM ( n = 3).

Article Snippet: TQ (HY-D0803, MCE); GEM (HY-17026, MCE); dimethyl sulfoxide (Sigma); fetal bovine serum (GIBCO), RPMI-1640 medium (GIBCO); primary antibodies including anti-COL1A1 (67288-1-Ig, PROTEINTECH), anti-COL3A1 (22734-1-AP, PROTEINTECH), anti-COL5A1 (67604-1-Ig, PROTEINTECH), anti-HIF-1α (20960-1-AP, PROTEINTECH), anti-OH-HIF-1α (3434T, CST), anti-TGFβ1 (21898-1-AP, PROTEINTECH), anti-Smad2 (12570-1-AP, PROTEINTECH), anti-Smad3 (66516-1-Ig, PROTEINTECH); hTGFβ (HY-P70543, MCE); LY2157299 (HY-13226, MCE); PX-478 (HY-10231, MCE); 26S proteasome inhibitor (MG132) (HY-132598, MCE); CCK-8 kit (Biyuntian Institute of Biotechnology); TUNEL Kit (11684817910, Roche); Annexin V-FITC Apoptosis Detection Kit (AO 2001-02P-G, Tianjin Sanjian Biotechnology Co., Ltd.) were used in this study.

Techniques: Western Blot