HY-132592 Search Results


z vad fmk  (MedChemExpress)
98
MedChemExpress z vad fmk
Z Vad Fmk, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 98 stars, based on 1 article reviews
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98/100 stars
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(r)-mg-132  (MedChemExpress)
93
MedChemExpress (r)-mg-132
(R) Mg 132, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
(r)-mg-132 - by Bioz Stars, 2026-03
93/100 stars
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mg132  (MedChemExpress)
96
MedChemExpress mg132
Mg132, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
mg132 - by Bioz Stars, 2026-03
96/100 stars
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inclisiran  (MedChemExpress)
93
MedChemExpress inclisiran
A , Experimental workflow for characterising inflammatory and oxidative stress in VSMCs. B . PCSK9 protein abundance (log2 MS intensity) in observed (dark dots) and imputed (light dots) samples across conditions, with statistical comparisons shown. C , Knowledge-graph analysis of POVPC-induced gene expression changes; D , Pathway activation analysis comparing control (ethanol, grey), POVPC treatment (red) and PCSK9 knockdown <t>(Inclisiran,</t> blue) effects.
Inclisiran, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/inclisiran/product/MedChemExpress
Average 93 stars, based on 1 article reviews
inclisiran - by Bioz Stars, 2026-03
93/100 stars
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26s proteasome inhibitor  (MedChemExpress)
90
MedChemExpress 26s proteasome inhibitor
Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + <t>MG132-treated</t> PANC-1 cells under hypoxic conditions ( n = 3).
26s Proteasome Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
26s proteasome inhibitor - by Bioz Stars, 2026-03
90/100 stars
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mg 132  (MedChemExpress)
96
MedChemExpress mg 132
Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + <t>MG132-treated</t> PANC-1 cells under hypoxic conditions ( n = 3).
Mg 132, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
mg 132 - by Bioz Stars, 2026-03
96/100 stars
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pmsf  (MedChemExpress)
96
MedChemExpress pmsf
Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + <t>MG132-treated</t> PANC-1 cells under hypoxic conditions ( n = 3).
Pmsf, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pmsf/product/MedChemExpress
Average 96 stars, based on 1 article reviews
pmsf - by Bioz Stars, 2026-03
96/100 stars
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necrostatin 1  (MedChemExpress)
96
MedChemExpress necrostatin 1
Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + <t>MG132-treated</t> PANC-1 cells under hypoxic conditions ( n = 3).
Necrostatin 1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/necrostatin 1/product/MedChemExpress
Average 96 stars, based on 1 article reviews
necrostatin 1 - by Bioz Stars, 2026-03
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Image Search Results


A , Experimental workflow for characterising inflammatory and oxidative stress in VSMCs. B . PCSK9 protein abundance (log2 MS intensity) in observed (dark dots) and imputed (light dots) samples across conditions, with statistical comparisons shown. C , Knowledge-graph analysis of POVPC-induced gene expression changes; D , Pathway activation analysis comparing control (ethanol, grey), POVPC treatment (red) and PCSK9 knockdown (Inclisiran, blue) effects.

Journal: medRxiv

Article Title: Spatially resolved proteomic signatures of atherosclerotic carotid artery disease

doi: 10.1101/2025.02.09.25321955

Figure Lengend Snippet: A , Experimental workflow for characterising inflammatory and oxidative stress in VSMCs. B . PCSK9 protein abundance (log2 MS intensity) in observed (dark dots) and imputed (light dots) samples across conditions, with statistical comparisons shown. C , Knowledge-graph analysis of POVPC-induced gene expression changes; D , Pathway activation analysis comparing control (ethanol, grey), POVPC treatment (red) and PCSK9 knockdown (Inclisiran, blue) effects.

Article Snippet: Subsequently, 25 nM Inclisiran (HY-132591, MedChemExpress) or 25 nM negative control siRNA (AM4614, Ambion) was introduced in SF&PRF medium using RNAiMAX (13778-150, Thermo Fisher).

Techniques: Expressing, Activation Assay, Control, Knockdown

A , Number of proteins quantified in cellular proteome (orange) and secretome (green) across experimental conditions. B , Principal component analysis of cellular proteome and secretome samples showing separation of treatment conditions. C-D , Volcano plots showing differentially expressed proteins (red dots, p < 0.05) in response to D, POVPC treatment and E, PCSK9 knockdown compared to controls (siNEG). E , Integrated knowledge graph analysis of proteins significantly upregulated upon PCSK9 knockdown with Inclisiran (red: upregulated, blue: downregulated).

Journal: medRxiv

Article Title: Spatially resolved proteomic signatures of atherosclerotic carotid artery disease

doi: 10.1101/2025.02.09.25321955

Figure Lengend Snippet: A , Number of proteins quantified in cellular proteome (orange) and secretome (green) across experimental conditions. B , Principal component analysis of cellular proteome and secretome samples showing separation of treatment conditions. C-D , Volcano plots showing differentially expressed proteins (red dots, p < 0.05) in response to D, POVPC treatment and E, PCSK9 knockdown compared to controls (siNEG). E , Integrated knowledge graph analysis of proteins significantly upregulated upon PCSK9 knockdown with Inclisiran (red: upregulated, blue: downregulated).

Article Snippet: Subsequently, 25 nM Inclisiran (HY-132591, MedChemExpress) or 25 nM negative control siRNA (AM4614, Ambion) was introduced in SF&PRF medium using RNAiMAX (13778-150, Thermo Fisher).

Techniques: Knockdown

Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions ( n = 3).

Journal: Frontiers in Pharmacology

Article Title: Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α

doi: 10.3389/fphar.2023.1138265

Figure Lengend Snippet: Analysis of apoptosis in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions ( n = 3).

Article Snippet: TQ (HY-D0803, MCE); GEM (HY-17026, MCE); dimethyl sulfoxide (Sigma); fetal bovine serum (GIBCO), RPMI-1640 medium (GIBCO); primary antibodies including anti-COL1A1 (67288-1-Ig, PROTEINTECH), anti-COL3A1 (22734-1-AP, PROTEINTECH), anti-COL5A1 (67604-1-Ig, PROTEINTECH), anti-HIF-1α (20960-1-AP, PROTEINTECH), anti-OH-HIF-1α (3434T, CST), anti-TGFβ1 (21898-1-AP, PROTEINTECH), anti-Smad2 (12570-1-AP, PROTEINTECH), anti-Smad3 (66516-1-Ig, PROTEINTECH); hTGFβ (HY-P70543, MCE); LY2157299 (HY-13226, MCE); PX-478 (HY-10231, MCE); 26S proteasome inhibitor (MG132) (HY-132598, MCE); CCK-8 kit (Biyuntian Institute of Biotechnology); TUNEL Kit (11684817910, Roche); Annexin V-FITC Apoptosis Detection Kit (AO 2001-02P-G, Tianjin Sanjian Biotechnology Co., Ltd.) were used in this study.

Techniques:

TQ and GEM affect cell apoptosis and motility in PC cells under hypoxic conditions. (A) Transwell (migration and invasion) of NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (B) Statistical analysis of Figure 6 (apoptosis analysis). (C) Statistical analysis of (A) (transwell migration). (D) Statistical analysis of (A) (transwell invasion). * p < 0.05 compared with NC; # p < 0.05 compared with TQ or GEM; and p < 0.05 compared with TQ + GEM ( n = 3).

Journal: Frontiers in Pharmacology

Article Title: Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α

doi: 10.3389/fphar.2023.1138265

Figure Lengend Snippet: TQ and GEM affect cell apoptosis and motility in PC cells under hypoxic conditions. (A) Transwell (migration and invasion) of NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (B) Statistical analysis of Figure 6 (apoptosis analysis). (C) Statistical analysis of (A) (transwell migration). (D) Statistical analysis of (A) (transwell invasion). * p < 0.05 compared with NC; # p < 0.05 compared with TQ or GEM; and p < 0.05 compared with TQ + GEM ( n = 3).

Article Snippet: TQ (HY-D0803, MCE); GEM (HY-17026, MCE); dimethyl sulfoxide (Sigma); fetal bovine serum (GIBCO), RPMI-1640 medium (GIBCO); primary antibodies including anti-COL1A1 (67288-1-Ig, PROTEINTECH), anti-COL3A1 (22734-1-AP, PROTEINTECH), anti-COL5A1 (67604-1-Ig, PROTEINTECH), anti-HIF-1α (20960-1-AP, PROTEINTECH), anti-OH-HIF-1α (3434T, CST), anti-TGFβ1 (21898-1-AP, PROTEINTECH), anti-Smad2 (12570-1-AP, PROTEINTECH), anti-Smad3 (66516-1-Ig, PROTEINTECH); hTGFβ (HY-P70543, MCE); LY2157299 (HY-13226, MCE); PX-478 (HY-10231, MCE); 26S proteasome inhibitor (MG132) (HY-132598, MCE); CCK-8 kit (Biyuntian Institute of Biotechnology); TUNEL Kit (11684817910, Roche); Annexin V-FITC Apoptosis Detection Kit (AO 2001-02P-G, Tianjin Sanjian Biotechnology Co., Ltd.) were used in this study.

Techniques: Migration

TQ might affect GEM sensitivity by regulating ECM production in PC cells under hypoxic conditions. (A) Western blot of HIF-1α in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (B) Western blot of ECM production-related proteins and TGFβ1 in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (C) Statistical analysis of (A , B) . * p < 0.05 compared with NC; # p < 0.05 compared with TQ or GEM; and p < 0.05 compared with TQ + GEM ( n = 3).

Journal: Frontiers in Pharmacology

Article Title: Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α

doi: 10.3389/fphar.2023.1138265

Figure Lengend Snippet: TQ might affect GEM sensitivity by regulating ECM production in PC cells under hypoxic conditions. (A) Western blot of HIF-1α in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (B) Western blot of ECM production-related proteins and TGFβ1 in NC, TQ-, GEM-, TQ + GEM-, and TQ + GEM + MG132-treated PANC-1 cells under hypoxic conditions. (C) Statistical analysis of (A , B) . * p < 0.05 compared with NC; # p < 0.05 compared with TQ or GEM; and p < 0.05 compared with TQ + GEM ( n = 3).

Article Snippet: TQ (HY-D0803, MCE); GEM (HY-17026, MCE); dimethyl sulfoxide (Sigma); fetal bovine serum (GIBCO), RPMI-1640 medium (GIBCO); primary antibodies including anti-COL1A1 (67288-1-Ig, PROTEINTECH), anti-COL3A1 (22734-1-AP, PROTEINTECH), anti-COL5A1 (67604-1-Ig, PROTEINTECH), anti-HIF-1α (20960-1-AP, PROTEINTECH), anti-OH-HIF-1α (3434T, CST), anti-TGFβ1 (21898-1-AP, PROTEINTECH), anti-Smad2 (12570-1-AP, PROTEINTECH), anti-Smad3 (66516-1-Ig, PROTEINTECH); hTGFβ (HY-P70543, MCE); LY2157299 (HY-13226, MCE); PX-478 (HY-10231, MCE); 26S proteasome inhibitor (MG132) (HY-132598, MCE); CCK-8 kit (Biyuntian Institute of Biotechnology); TUNEL Kit (11684817910, Roche); Annexin V-FITC Apoptosis Detection Kit (AO 2001-02P-G, Tianjin Sanjian Biotechnology Co., Ltd.) were used in this study.

Techniques: Western Blot