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IC 50 of TOR/PI3 kinase inhibitors 1 .

Journal: International Journal of Molecular Sciences

Article Title: Effects of Target of Rapamycin and Phosphatidylinositol 3-Kinase Inhibitors and Other Autophagy-Related Supplements on Life Span in y w Male Drosophila melanogaster

doi: 10.3390/ijms252111504

Figure Lengend Snippet: IC 50 of TOR/PI3 kinase inhibitors 1 .

Article Snippet: The compounds AZD8055, Ku-0063794, LY294002, PI-103 hydrochloride, PP242, PX-866-17OH, Torin2, wortmannin, WYE-28 and WYE-132 were from Chemdea (Ridgewood, NJ, USA).

Techniques:

Life spans of flies supplemented with ( A ) spermidine, ( B ) DMSO or TOR/PI3K inhibitors: ( C ) AZD8055, ( D ) Ku-0063794, ( E ) LY294002, ( F ) PI-103 hydrochloride (HCl), ( G ) PX-866-17OH, ( H ) rapamycin (Rapa) high dose, ( I ) Rapa low dose, ( J ) Torin2, ( K ) wortmannin (Wort), ( L ) WYE-28 and ( M ) WYE-132. Supplements were provided beginning in early adult life (arrows). Green indicates life extension and red indicates life shortening vs. both regular and H 2 O controls, or vs. H 2 O controls alone for PI-103 hydrochloride ( p < 0.050 based on logrank tests).

Journal: International Journal of Molecular Sciences

Article Title: Effects of Target of Rapamycin and Phosphatidylinositol 3-Kinase Inhibitors and Other Autophagy-Related Supplements on Life Span in y w Male Drosophila melanogaster

doi: 10.3390/ijms252111504

Figure Lengend Snippet: Life spans of flies supplemented with ( A ) spermidine, ( B ) DMSO or TOR/PI3K inhibitors: ( C ) AZD8055, ( D ) Ku-0063794, ( E ) LY294002, ( F ) PI-103 hydrochloride (HCl), ( G ) PX-866-17OH, ( H ) rapamycin (Rapa) high dose, ( I ) Rapa low dose, ( J ) Torin2, ( K ) wortmannin (Wort), ( L ) WYE-28 and ( M ) WYE-132. Supplements were provided beginning in early adult life (arrows). Green indicates life extension and red indicates life shortening vs. both regular and H 2 O controls, or vs. H 2 O controls alone for PI-103 hydrochloride ( p < 0.050 based on logrank tests).

Article Snippet: The compounds AZD8055, Ku-0063794, LY294002, PI-103 hydrochloride, PP242, PX-866-17OH, Torin2, wortmannin, WYE-28 and WYE-132 were from Chemdea (Ridgewood, NJ, USA).

Techniques:

Adult mean life spans of flies supplemented with DMSO, spermidine or TOR/PI3K inhibitors beginning in early adult life.

Journal: International Journal of Molecular Sciences

Article Title: Effects of Target of Rapamycin and Phosphatidylinositol 3-Kinase Inhibitors and Other Autophagy-Related Supplements on Life Span in y w Male Drosophila melanogaster

doi: 10.3390/ijms252111504

Figure Lengend Snippet: Adult mean life spans of flies supplemented with DMSO, spermidine or TOR/PI3K inhibitors beginning in early adult life.

Article Snippet: The compounds AZD8055, Ku-0063794, LY294002, PI-103 hydrochloride, PP242, PX-866-17OH, Torin2, wortmannin, WYE-28 and WYE-132 were from Chemdea (Ridgewood, NJ, USA).

Techniques: Concentration Assay, Control