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Bioactive compounds and nutraceuticals used for the management, treatment, or prevention of OA in humans.

Journal: Pharmaceuticals

Article Title: Nutritional Epigenomics: Bioactive Dietary Compounds in the Epigenetic Regulation of Osteoarthritis

doi: 10.3390/ph17091148

Figure Lengend Snippet: Bioactive compounds and nutraceuticals used for the management, treatment, or prevention of OA in humans.

Article Snippet: Casticin (Vitexicarpin) , Vitex rotundifolia L. Polymethoxyflavonoid , Effects in IL-1β-induced OA chondrocytes: Prevented inflammation by inhibition of NF-κB signalling pathway Decreased NO, PGE2, TNF-α, IL-6, MMP-3, MMP-13, ADAMTS-4 and ADAMTS-5 production Inhibited NOS2 and COX2 mRNA and protein expression Increased ACAN and COL2A1 mRNA expression , [ ] .

Techniques: Activation Assay, Derivative Assay, Expressing, Activity Assay, Inhibition, Membrane, Gene Expression, Phospho-proteomics, Translocation Assay, Functional Assay, Adjuvant, Comparison, Drug discovery, Modification, Solubility, Cannabis, Formulation, Marker, Control, Binding Assay, Sedimentation, Ex Vivo, In Vitro, Produced, Ubiquitin Proteomics, Concentration Assay, Clinical Proteomics