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Cytotoxicity of amphiphilic PVP micellar NPs loaded with bortezomib (PVP-B) or prothionamide (PVP-P) in monolayer T98G and U87 human glioblastoma cell lines evaluated by MTT test after 24, 48 or 72 h of incubation. * P<0.05 and ** P<0.01 by Student's t-test. PVP, poly(N-vinylpyrrolidone); NPs, nanoparticles.

Journal: Biomedical Reports

Article Title: Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos

doi: 10.3892/br.2024.1725

Figure Lengend Snippet: Cytotoxicity of amphiphilic PVP micellar NPs loaded with bortezomib (PVP-B) or prothionamide (PVP-P) in monolayer T98G and U87 human glioblastoma cell lines evaluated by MTT test after 24, 48 or 72 h of incubation. * P<0.05 and ** P<0.01 by Student's t-test. PVP, poly(N-vinylpyrrolidone); NPs, nanoparticles.

Article Snippet: Human glioblastoma cell line T98G (cat. no. CRL-1690), glioblastoma of unknown origin U87 (cat. no. HTB-14) and normal human dermal fibroblasts (cat. no. PCS-201-012) were obtained from the American Type Culture Collection.

Techniques: Incubation

Cytotoxicity of amphiphilic PVP micellar NPs loaded with bortezomib (PVP-B) or prothionamide (PVP-P) in multicellular spheroids of human glioblastoma cells T98G or U87 evaluated by MTT test after 48 or 72 h of incubation. * P<0.05 and ** P<0.01 by Student's t-test. PVP, poly(N-vinylpyrrolidone); NPs, nanoparticles.

Journal: Biomedical Reports

Article Title: Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos

doi: 10.3892/br.2024.1725

Figure Lengend Snippet: Cytotoxicity of amphiphilic PVP micellar NPs loaded with bortezomib (PVP-B) or prothionamide (PVP-P) in multicellular spheroids of human glioblastoma cells T98G or U87 evaluated by MTT test after 48 or 72 h of incubation. * P<0.05 and ** P<0.01 by Student's t-test. PVP, poly(N-vinylpyrrolidone); NPs, nanoparticles.

Article Snippet: Human glioblastoma cell line T98G (cat. no. CRL-1690), glioblastoma of unknown origin U87 (cat. no. HTB-14) and normal human dermal fibroblasts (cat. no. PCS-201-012) were obtained from the American Type Culture Collection.

Techniques: Incubation

The morphology of 3D tumor spheroids generated from human glioblastoma cells T98G or U87 after incubation with 500 µg/ml of amphiphilic PVP micellar nanoparticles loaded with bortezomib (PVP-B) or prothionamide (PVP-P) for 48 h or 72 h. The spheroids were visualized using an inverted light microscope. Scale bar, 200 µm. PVP, poly(N-vinylpyrrolidone).

Journal: Biomedical Reports

Article Title: Assessment of the effects of amphiphilic poly (N‑vinylpyrrolidone) nanoparticles loaded with bortezomib on glioblastoma cell lines and zebrafish embryos

doi: 10.3892/br.2024.1725

Figure Lengend Snippet: The morphology of 3D tumor spheroids generated from human glioblastoma cells T98G or U87 after incubation with 500 µg/ml of amphiphilic PVP micellar nanoparticles loaded with bortezomib (PVP-B) or prothionamide (PVP-P) for 48 h or 72 h. The spheroids were visualized using an inverted light microscope. Scale bar, 200 µm. PVP, poly(N-vinylpyrrolidone).

Article Snippet: Human glioblastoma cell line T98G (cat. no. CRL-1690), glioblastoma of unknown origin U87 (cat. no. HTB-14) and normal human dermal fibroblasts (cat. no. PCS-201-012) were obtained from the American Type Culture Collection.

Techniques: Generated, Incubation, Light Microscopy