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Scheme 6. Selective inhibition of CCL2/7/8 production by bindarit, as well as blocking of CCR1 and CCR3 by selective (J113863, SB328437) or dual <t>(UCB35625)</t> antagonists, reduced even fully developed mechanical and thermal hypersensitivity in murine model of neuropathic pain.
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Scheme 6. Selective inhibition of CCL2/7/8 production by bindarit, as well as blocking of CCR1 and CCR3 by selective (J113863, SB328437) or dual (UCB35625) antagonists, reduced even fully developed mechanical and thermal hypersensitivity in murine model of neuropathic pain.

Journal: Cells

Article Title: Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2/7/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain.

doi: 10.3390/cells12010098

Figure Lengend Snippet: Scheme 6. Selective inhibition of CCL2/7/8 production by bindarit, as well as blocking of CCR1 and CCR3 by selective (J113863, SB328437) or dual (UCB35625) antagonists, reduced even fully developed mechanical and thermal hypersensitivity in murine model of neuropathic pain.

Article Snippet: Single Intrathecal Administration J113863, SB328437, UCB35625 and J113863+SB328437 (Tocris) were dissolved in 70% DMSO and administered once i.t. to operated male and female animals on the 12th day and post CCI at a dose of 20 μg/5 μL each.

Techniques: Inhibition, Blocking Assay