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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the <t>CLP</t> test measured with a stopwatch (graphs B, D, and F). Graph A, <t>haloperidol</t> bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.
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Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the CLP test measured with a stopwatch (graphs B, D, and F). Graph A, haloperidol bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.

Journal: Pharmacology, biochemistry, and behavior

Article Title: Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: assessment of a new, commercially available, semi-automated instrument.

doi: 10.1016/j.pbb.2014.02.013

Figure Lengend Snippet: Fig. 2. Mean time in seconds in the bar test measured using the instrument (Inst) (graphs A, C, E), instrument plus stopwatch (SW + Inst) (graph E, solid line), or in the CLP test measured with a stopwatch (graphs B, D, and F). Graph A, haloperidol bar instrument, AED50 = 0.29 mg/kg. Graph B, haloperidol CLP, AED50 = 0.38 mg/kg. Graph C, clozapine bar instrument, no significant catalepsy. Graph D, clozapine CLP, significant catalepsy at 40 mg/kg. Graph E, olanzapine stopwatch + instrument (SW + Inst.), significant catalepsy at 40 mg/kg. Graph E, Inst. only, gripping problems prevented accurate detection of time on the bar. Dashed line shown only to illustrate problem. Graph F, olanzapine CLP, significant catalepsy at 40 mg/kg. n = 7 rats/dose. Compared to vehicle, **, ***, and **** indicate p b 0.01, 0.001, and 0.0001 respectively.

Article Snippet: Contents lists available at ScienceDirect Pharmacology, Biochemistry and Behavior j ourna l homepage: www.e lsev ie r .com/ locate /pharmbiochembeh Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: Assessment of a new, commercially available, semi-automated instrument Barbara Bricker, Dinithia Sampson, Seth Y. Ablordeppey Division of Basic Pharmaceutical Sciences, Florida A&M University, College of Pharmacy and Pharmaceutical Sciences, Tallahassee, FL 32307, USA http://dx.doi.org/10.1016/j.pbb.2014.02.013 0091-3057/Published by Elsevier Inc. a b s t r a c t a r t i c l e i n f o Article history: Received 12 August 2013 Received in revised form 7 January 2014 Accepted 16 February 2014 Available online 21 February 2014 Keywords: Catalepsy instrument Bar test for catalepsy Extrapyramidal side effect (EPS) Crossed-leg position (CLP) test Typical antipsychotics Atypical antipsychotics Haloperidol induced catalepsy was determined using the classic bar test and a new MED Associates Catalepsy Test Chamber instrument.

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