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Spatial organization and cell-cell communication networks in the tumor microenvironment. (A–C) The developmental trajectories of cell sub-populations from a spatial perspective are investigated. (D, E) Heatmap and network diagrams displaying cell–cell dependency analysis in the colocated, neighboring, and extended neighboring (15-point) regions of the spatial <t>transcriptomics</t> data. (F) The interaction heatmap visualized the intensity of intercellular interactions mediated by the ligand-receptor pairs. (G) The spatial cell communication network diagram illustrates that NUhighepi exhibit a higher intensity of cell communication with other cells. (H) Circos plot summarizing cell-type-specific interaction patterns.
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Spatial organization and cell-cell communication networks in the tumor microenvironment. (A–C) The developmental trajectories of cell sub-populations from a spatial perspective are investigated. (D, E) Heatmap and network diagrams displaying cell–cell dependency analysis in the colocated, neighboring, and extended neighboring (15-point) regions of the spatial transcriptomics data. (F) The interaction heatmap visualized the intensity of intercellular interactions mediated by the ligand-receptor pairs. (G) The spatial cell communication network diagram illustrates that NUhighepi exhibit a higher intensity of cell communication with other cells. (H) Circos plot summarizing cell-type-specific interaction patterns.

Journal: Frontiers in Oncology

Article Title: Spatial transcriptome and single-cell sequencing reveal the role of nucleotide metabolism in breast cancer progression and tumor microenvironment

doi: 10.3389/fonc.2025.1703778

Figure Lengend Snippet: Spatial organization and cell-cell communication networks in the tumor microenvironment. (A–C) The developmental trajectories of cell sub-populations from a spatial perspective are investigated. (D, E) Heatmap and network diagrams displaying cell–cell dependency analysis in the colocated, neighboring, and extended neighboring (15-point) regions of the spatial transcriptomics data. (F) The interaction heatmap visualized the intensity of intercellular interactions mediated by the ligand-receptor pairs. (G) The spatial cell communication network diagram illustrates that NUhighepi exhibit a higher intensity of cell communication with other cells. (H) Circos plot summarizing cell-type-specific interaction patterns.

Article Snippet: Breast cancer spatial transcriptomics (ST) data were acquired from the GEO database ( https://www.ncbi.nlm.nih.gov/geo/ ) and 10x Genomics official website ( https://www.10xgenomics.com/ ).

Techniques: